Functional implication of truncated P-cadherin expression in malignant melanoma

Bauer, Robert; Bosserhoff, Anja‐Katrin

doi:10.1016/j.yexmp.2006.07.002

Cited by 13 publications

(14 citation statements)

References 22 publications

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“…Mature melanocytes, although derived from the neural crest, reside in the basal layer of the epidermis where they establish heterotypic cell-cell interactions with basal keratinocytes through the mediation of E-cadherin (32). P-cadherin is also expressed in normal melanocytes and also likely plays a role in regulating regular cell-cell interactions between melanocytes and their surrounding cells (33). The down-regulation of either E-cadherin or P-cadherin, or the induction of N-cadherin, facilitates melanoma cell migration and invasion in in vitro assays (34)(35)(36).…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Cadherin-Based Adhesion Molecules in Cutaneous Malignant Melanoma

Kreizenbeck¹,

Berger²,

Subtil³

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: The need for novel molecular prognostic markers that can supplement validated clinicopathologic correlates for cutaneous malignant melanoma is well recognized. Proteins that mediate the epithelialmesenchymal transition, the process by which a cancer cell disengages from its parent tumor, are important candidates. Methods: The prognostic relevance of E-cadherin, N-cadherin, and P-cadherin, calcium-dependent transmembrane glycoproteins that regulate cell-cell adhesion, and their adaptors, A-catenin, B-catenin, and p120-catenin, was evaluated on a cohort of 201 primary and 274 metastatic melanoma tumors using fluorescencebased immunohistochemical methods and Automated Quantitative Analysis of protein expression on digitally captured photomicrographs. Results: Increasing levels of N-cadherin expression improved overall survival (log-rank = 7.31; P = 0.03) but did not retain significance following adjustment for established clinicopathologic correlates (P = 0.50). Higher levels of E-cadherin approached significance for favorable prognosis on both univariate (P = 0.13)

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Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Cadherin-Based Adhesion Molecules in Cutaneous Malignant Melanoma

Kreizenbeck¹,

Berger²,

Subtil³

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…The anti-invasive effect of P-cadherin was also recently confirmed in in vivo experiments, showing that its expression is refractory to invasive signals induced by myofibroblasts. Nevertheless, it was found a secreted truncated variant of P-cadherin in malignant melanomas, which negatively regulates cell-cell adhesion and induces a more motile phenotype, thus playing an important role in migration and metastasis of melanoma cells (Bauer and Bosserhoff, 2006).…”

Section: P-cadherin Role In Adhesion Invasion and Motilitymentioning

confidence: 99%

P-cadherin role in normal breast development and cancer

Albergaria

Ribeiro²,

Vieira³

et al. 2011

Int. J. Dev. Biol.

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P-cadherin is a cell-cell adhesion molecule, whose expression is highly associated with undifferentiated cells in normal adult epithelial tissues, as well as with poorly differentiated carcinomas. Its expression has been already reported in human embryonic stem cells and it is presumed to be a marker of stem or progenitor cells of some epithelial tissues. In normal breast, P-cadherin has an essential role during ductal mammary branching, being expressed by the monolayer of epithelial cap cells at the end buds. In mature mammary tissue, its expression is restricted to the myoepithelium; it has been postulated that it may also be present in early luminal progenitor cells. In breast cancer, P-cadherin is frequently overexpressed in high-grade tumours, being a well-established indicator of poor patient prognosis. It has been reported as an important inducer of cancer cell migration and invasion, with underlying molecular mechanisms involving the signalling mediated by its juxtamembrane domain, the secretion of matrix metalloproteases to the extracellular media, and the cleavage of a P-cadherin soluble form with pro-invasive activity. Intracellularly, this protein interferes with the endogenous cadherin/catenin complex, inducing p120-catenin delocalization to the cytoplasm, and the consequent activation of Rac1/Cdc42 and associated alterations in the actin cytoskeleton. Considering P-cadherin's role in cancer cell invasion and metastasis formation, a humanized monoclonal antibody was recently produced to antagonize P-cadherin-associated signalling pathways, which is currently under Phase I clinical trials. In this review, the most important findings about the role of P-cadherin in normal breast development and cancer will be illustrated and discussed, with emphasis on the most recent data.

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“…CDH3 has been found to be involved in a broad spectrum of cancers including colorectal cancer 64–71. The gene is identified as accurate prognostic indicator of several tumors due to its marked up-regulation in these tumors 66,68,71,72. Our rules show that it is over-expressed in colon tumor as well.…”

Section: Analysis Of Biological Relevancementioning

confidence: 62%

Microarray-Based Cancer Prediction Using Soft Computing Approach

Wang

Gotoh

2009

Cancer Inform

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One of the difficulties in using gene expression profiles to predict cancer is how to effectively select a few informative genes to construct accurate prediction models from thousands or ten thousands of genes. We screen highly discriminative genes and gene pairs to create simple prediction models involved in single genes or gene pairs on the basis of soft computing approach and rough set theory. Accurate cancerous prediction is obtained when we apply the simple prediction models for four cancerous gene expression datasets: CNS tumor, colon tumor, lung cancer and DLBCL. Some genes closely correlated with the pathogenesis of specific or general cancers are identified. In contrast with other models, our models are simple, effective and robust. Meanwhile, our models are interpretable for they are based on decision rules. Our results demonstrate that very simple models may perform well on cancerous molecular prediction and important gene markers of cancer can be detected if the gene selection approach is chosen reasonably.

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Functional implication of truncated P-cadherin expression in malignant melanoma

Cited by 13 publications

References 22 publications

Prognostic Significance of Cadherin-Based Adhesion Molecules in Cutaneous Malignant Melanoma

Prognostic Significance of Cadherin-Based Adhesion Molecules in Cutaneous Malignant Melanoma

P-cadherin role in normal breast development and cancer

Microarray-Based Cancer Prediction Using Soft Computing Approach

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