Functional Impairment of the Brainstem in Infants With Bronchopulmonary Dysplasia

Abstract

The results suggest poor myelination and synaptic function of the brainstem in infants with bronchopulmonary dysplasia, resulting in impaired functional integrity. In comparison, peripheral neural function was relatively intact.

Small-for-gestation birth exerts a minor additional effect on functional impairment of the auditory brainstem in high-risk babies born at late preterm

“…The general study procedures, approved by the Ethics Committee of the Children's Hospital of Fudan University in Shanghai, were the same as we previously reported (Jiang and Li, 2015;Jiang et al, 2012Jiang et al, , 2015Wilkinson et al, 2007). The recording, using Nicolet Spirit 2000 Portable Evoked Potential System (Nicolet Biomedical Inc. Madison, WI, USA), was made while the infant fell asleep naturally, often after a feed.…”

“…Any possible effect of threshold elevation and peripheral hearing loss on the identification and measurements of MLS BAER components was minimized. The clicks were presented at four repetition rates to detect any variation in the MLS BAER results at different rates and examine click rate-dependent change (Jiang, 2012(Jiang, , 2015Jiang et al, 2012;Wilkinson et al, 2007). Two runs of recordings to each stimulus condition were made to evaluate the reproducibility of recorded MLS BAER waveforms.…”

Neural conduction impairment in the auditory brainstem and the prevalence in term babies in neonatal intensive care unit

“…Excluded were also those who exposed to potentially ototoxic drugs such as aminoglycosides (mainly amikacin), and diuretics (furosemide), Genetic and metabolic disorders associated with hearing loss. Any babies who had a BAER threshold P40 dB normal hearing level (nHL) had been excluded from study entry to avoid any significant effect of peripheral hearing problems on the measurements of MLS BAER wave components so as to analyse MLS BAER variables more reliably and accurately, the same as our previous MLS BAER studies (Jiang, 2012;Jiang and Chen, 2014;Jiang et al, 2003Jiang et al, , 2005Jiang et al, , 2010Wilkinson et al, 2007). All our babies passed the neonatal hearing screening.…”

“…For those with a BAER threshold, which was determined as the lowest intensity at which wave V can be recognized reliably in conventional BAER, >20 dB nHL (3 babies at 25 and 2 at 30 dB nHL), higher intensities (70 and 75 dB nHL, respectively) were also used. This allowed to collect MLS BAER data at the intensity 40 dB or slightly higher above the threshold of each subject, and thus minimize any effect of threshold elevation and slight peripheral hearing loss on MLS BAER components (Jiang et al, 2003(Jiang et al, , 2005(Jiang et al, , 2010Wilkinson et al, 2007). Two runs of MLS BAER recording were made for each stimulus condition to evaluate reproducibility of the recorded waveforms.…”

“…More recently, the MLS technique has been introduced to study the BAER in babies with perinatal problems. These studies have proven that the MLS technique enhances detection of some neuropathology in the neonatal brain, typically hypoxia-ischemia (Jiang, 2012;Jiang and Chen, 2014;Jiang et al, 2003Jiang et al, , 2005Jiang et al, , 2010Wilkinson et al, 2007).…”