Functional impact of pediatric postthrombotic syndrome

Bastas, Denise; Brandão, Leonardo R.; Allen, Diane D.; Vincelli, Jennifer; Amiri, Nour; Abdul-Samad, Karem; Liu, Kuan; Stephens, Samantha; Avila, Laura

doi:10.1016/j.jtha.2023.01.004

Cited by 2 publications

(1 citation statement)

References 33 publications

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“…26,34 PTS has been characterized as a condition with significant challenges. 23,39,40 Interestingly, the pediatric survivors in this study who had a PTS diagnosis did not seem to carry a noticeable burden.…”

Section: Discussionmentioning

confidence: 66%

Sequelae and post‐thrombotic syndrome after venous thromboembolism in acute lymphoblastic leukemia survivors treated on the NOPHO ALL2008 protocol

Dam,

Lynggaard,

Jónsson

et al. 2024

Pediatric Blood & Cancer

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The treatment of acute lymphoblastic leukemia (ALL) is frequently complicated by toxicity, including venous thromboembolism (VTE) affecting roughly 8% of patients. VTE can lead to post‐thrombotic syndrome (PTS), a group of signs and symptoms developed as a complication to deep venous thrombosis (DVT), imposing risk of permanent disability and reduced quality of life (QoL). PTS prevalence ranges from 0% to 70%, reflecting very heterogenous cohorts and assessment tools. We aimed to estimate sequelae, including PTS and QoL in children and adults (<45 years old) who had a DVT during ALL treatment. PTS and QoL scores were obtained through use of Villalta and Modified Villalta Scale, PedsQL, and Short Form‐36 questionnaires. The cohort comprised 20 children (<18 years) and seven adults (median age: 12.9 years, range: 2–44 years) at the time of DVT diagnosis. In total, 25 ALL survivors underwent PTS examination. The examination took place when survivors were 7–48 years (median age: 20.3 years, median follow‐up time 6.8 years). QoL was assessed correlating cases with three matching ALL survivors without VTE. Two adults (15.4%) showed mild or moderate PTS. Eight children (66.7%) were diagnosed with mild PTS, while three cases had collaterals as sole symptoms. Pain or symptoms affecting daily life were reported by 16%. No difference in QoL was found (p = .9). This study underscores the need for comprehensive population‐based investigations with validation of PTS instruments in ALL survivors.

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