Functional Imaging of Working Memory in Parkinson's Disease: Compensations and Deficits

Marié, Rose‐Marie; Lozza, Catherine; Chavoix, Chantal; Defer, Gilles

doi:10.1111/j.1552-6569.2007.00152.x

Cited by 17 publications

(12 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The increased recruitment of normal networks and recruitment of novel areas shown here is consistent with research into cognitive deficits in PD. For example, during a working memory task, PD subjects showed increased activation of prefrontal and parietal areas as compared with controls, which correlated with task performance, and a novel correlation of posterior cingulate activity with task performance (Marié et al, 2007). Similarly, increases in the spatial extent of activation have been shown in the cognitive domain in PD; for example, Monchi et al (2004) showed that the PFC activation had increased amplitude and spatial extent (by voxel counts) during a setshifting task.…”

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Motor reserve and novel area recruitment: amplitude and spatial characteristics of compensation in Parkinson’s disease

Palmer

Abugharbieh

et al. 2009

Eur J of Neuroscience

View full text Add to dashboard Cite

Motor symptoms of Parkinson's disease (PD) do not appear until the majority of dopaminergic cells in the substantia nigra pars compacta are lost, suggesting significant redundancy or compensation in the motor systems affected by PD. Using functional magnetic resonance imaging, we examined whether compensation in PD is manifested by changes in amplitude and/or spatial extent of activity within normal networks (active motor reserve) and/or newly recruited regions [novel area recruitment (NAR)]. Ten PD subjects off and on medication and 10 age-matched controls performed a visually guided sinusoidal force task at 0.25, 0.5 and 0.75 Hz. Regression was used to determine the combination of regions where activation amplitude scaled linearly with movement speed in controls. We then determined the activation of PD subjects in this network, as well as the corresponding PD network. To measure the spatial variance of activation, we used an invariant spatial feature approach. Control subjects monotonically increased activity within striato-thalamo-cortical and cerebello-thalamo-cortical regions with increasing movement speed. In PD subjects, the activity of this network at low speeds was similar to that in controls at higher speeds. Additionally, PD subjects off medication demonstrated NARs of the bilateral cerebellum and primary motor cortex, which were incompletely normalized by levodopa. Our results suggest that PD subjects tap into motor reserve, increase the spatial extent of activation and demonstrate NAR to maintain near-normal motor output.

show abstract

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Motor reserve and novel area recruitment: amplitude and spatial characteristics of compensation in Parkinson’s disease

Palmer

Abugharbieh

et al. 2009

Eur J of Neuroscience

View full text Add to dashboard Cite

show abstract

“…Given the small sample size involved, which reduced the statistical power of our analyses, our data should be interpreted with caution, even though several previously published neuroimaging studies have included nine or even fewer PD patients (George et al, 1993; Owen et al, 1998; Whalen et al, 1998; Doder et al, 1999; Langenecker et al, 2004; van Veen and Carter, 2005; Marié et al, 2007; Monchi et al, 2007; Lewis et al, 2008). The pathology and typical aging problems [such as visual, motor (tremor), and dystonic impairments] found in these patients significantly complicates the generation of larger study groups, an issue that should be addressed in future studies.…”

Section: Discussionmentioning

confidence: 98%

Cognitive Rehabilitation in Parkinson’s Disease: Evidence from Neuroimaging

Nombela¹,

Bustillo²,

Castell³

et al. 2011

Front. Neur.

View full text Add to dashboard Cite

Cognitive impairment in Parkinson’s disease (PD) has received little attention to date and as such, there are currently very few treatment options available. The aim of the present study was to determine whether cognitive training might alleviate these cognitive symptoms and if so, whether such changes might be correlated with altered brain patterns. The performance of 10 PD patients and 10 paired healthy controls was assessed in a modified version of the Stroop task performed in association with functional magnetic resonance imaging, and half of the PD patients were given 6 months of cognitive daily training based on Sudoku exercises. Results showed that the training program improved the cognitive performance in the Stroop test of the trained Parkinson’s patients during MRI, specifically in terms of reaction time, and of correct and missing answers. Moreover, training provoked reduced cortical activation patterns with respect to untrained patients that were comparable to the patterns of activation observed in controls. Based on these findings, we propose that cognitive training can contribute significantly to save brain resources in PD patients, maybe by readdressing the imbalance caused by the alterations to inhibitory circuitry. Furthermore, these data strongly support the development and use of standardized cognitive training programs in PD patients.

show abstract

“…Due to the length of the subordinate sentences PD patient with a relative small working memory capacity showed a working memory overload and produced errors on the verb production task. Compensatory mechanisms in PD acting toward maintenance of performance (despite the underlying degenerative process) have recently also been proposed by Marié et al (2007). Based on their fMRI study, Marié et al (2007) concluded that PD patients have a timelimited working memory capacity.…”

Section: Role Of Executive Functions In Pd Patients' Verb Productionmentioning

confidence: 99%

The impact of executive functions on verb production in patients with Parkinson's disease

Colman

Koerts

Beilen

et al. 2009

Cortex

View full text Add to dashboard Cite

A growing number of studies suggest that language problems in Parkinson's disease (PD) are a result of executive dysfunction. To test this hypothesis we compared Dutch verb production in sentence context in a group of 28 PD patients with a control group consisting of 28 healthy participants matched for age, gender and education. All subjects were assessed on both verb production in sentence context as well as on cognitive functions relevant for sentence processing. PD patients scored lower than healthy controls on the verb production ability-scale and showed a response pattern in which performance was worse (1) in base than in derived position; (2) in present than in past tense; (3) for intransitive than in transitive verbs. For the PD group the score on the verb production ability-scale correlated significantly with set-switching and working memory. These results provide support for previous research suggesting that executive dysfunctions underlie the performance of the PD patients on verb production. It is furthermore suggested that because of failing automaticity, PD patients rely more on the cortically represented executive functions. Unfortunately, due to the disturbed intimate relation between the basal ganglia and the frontal cortex, these executive functions are also dysfunctional.

show abstract

Functional Imaging of Working Memory in Parkinson's Disease: Compensations and Deficits

Cited by 17 publications

References 55 publications

Motor reserve and novel area recruitment: amplitude and spatial characteristics of compensation in Parkinson’s disease

Motor reserve and novel area recruitment: amplitude and spatial characteristics of compensation in Parkinson’s disease

Cognitive Rehabilitation in Parkinson’s Disease: Evidence from Neuroimaging

The impact of executive functions on verb production in patients with Parkinson's disease

Contact Info

Product

Resources

About