Functional imaging of tumors. Part 1

Figueiras, R. García; Padhani, Anwar R.; Busquets, Joan Carles Vilanova; Goh, Vicky; Martin, C.

doi:10.1016/s2173-5107(10)70008-2

Cited by 3 publications

(3 citation statements)

References 55 publications

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“…In the quantitative analysis, it is possible to evaluate blood flow, which expresses the rate of delivery of blood (oxygen and nutrients) to the tumor; blood volume, which represents the functional microvessel density (ie, the volume of the vascular network that is functional in the tumor); and permeability or k-trans, which describes the rate of contrast material leakage into the extracellular space (81). Quantitative functional CT parameters have proved to be reproducible in body tumors and to have good interobserver and intraobserver agreement, although measurements obtained with different methods of analysis are not directly interchangeable (82,83).…”

Section: Assessment Based On Dynamic Contrast-enhanced Ct Evaluationmentioning

confidence: 99%

Metastatic Renal Cell Carcinoma: Radiologic Findings and Assessment of Response to Targeted Antiangiogenic Therapy by Using Multidetector CT

Brufau¹,

Cerqueda²,

Villalba³

et al. 2013

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115

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Recent advances in treatment of metastatic renal cell carcinoma (RCC), such as new molecular therapies that use novel antiangiogenic agents, have led to revision of the most frequently used guideline to evaluate tumor response to therapy: Response Evaluation Criteria in Solid Tumors (RECIST 1.1). Assessment of the response of metastatic RCC to therapy has traditionally been based on changes in target lesion size. However, the mechanism of action of newer antiangiogenic therapies is more cytostatic than cytotoxic, which leads to disease stabilization rather than to tumor regression. This change in tumor response makes RECIST 1.1--a system whose criteria are based exclusively on tumor size--inadequate to discriminate patients with early tumor progression from those with more progression-free disease and prolonged survival. New criteria such as changes in attenuation, morphology, and structure, as seen at contrast-enhanced multidetector computed tomography (CT), are being incorporated into new classifications used to assess response of metastatic RCC to antiangiogenic therapies. The new classifications provide better assessments of tumor response to the new therapies, but they have some limitations. The authors provide a practical review of these systems--the Choi, modified Choi, and Morphology, Attenuation, Size, and Structure (MASS) criteria--by explaining their differences and limitations that may influence the feasibility and reproducibility of these classifications. The authors review the use of multidetector CT in the detection of metastatic RCC and the different appearances and locations of these lesions. They also provide an overview of the new antiangiogenic therapies and their mechanisms of action and a brief introduction to functional imaging techniques. Functional imaging techniques, especially dynamic contrast-enhanced CT, seem promising for assessing response of metastatic RCC to treatment. Nonetheless, further studies are needed before functional imaging can be used in routine clinical practice.

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Section: Assessment Based On Dynamic Contrast-enhanced Ct Evaluationmentioning

confidence: 99%

Metastatic Renal Cell Carcinoma: Radiologic Findings and Assessment of Response to Targeted Antiangiogenic Therapy by Using Multidetector CT

Brufau¹,

Cerqueda²,

Villalba³

et al. 2013

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115

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“…2) Quantitative modeling in DCE-US: Under the hypothesis that the increased microvascular density (MVD) associated with tumor angiogenesis translates into increased blood supply demands, many investigators have relied on tissue perfusion quantification as a potential biomarker for tumor angiogenesis [7], [15], [24], [64], [65], [66], [67], [68].…”

Section: Pharmacokinetic Modeling Of Contrast Agents For Quantitamentioning

confidence: 99%

Mathematical Models of Contrast Transport Kinetics for Cancer Diagnostic Imaging: A Review

Turco

Wijkstra

Mischi

2016

IEEE Rev. Biomed. Eng.

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Angiogenesis plays a fundamental role in cancer growth and the formation of metastasis. Novel cancer therapies aimed at inhibiting angiogenic processes and/or disrupting angiogenic tumor vasculature are currently being developed and clinically tested. The need for earlier and improved cancer diagnosis, and for early evaluation and monitoring of therapeutic response to angiogenic treatment, have led to the development of several imaging methods for in vivo noninvasive assessment of angiogenesis. The combination of dynamic contrast-enhanced imaging with mathematical modeling of the contrast agent kinetics enables quantitative assessment of the structural and functional changes in the microvasculature that are associated with tumor angiogenesis. In this paper, we review quantitative imaging of angiogenesis with dynamic contrast-enhanced magnetic resonance imaging, computed tomography, and ultrasound.

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“…Afterwards, if another opposite gradient of the same magnitude is applied, only those protons that have not moved at all (restricted diffusion) will come back to the same phase. By contrast, the molecules with higher mobility will not recover their phase completely after the second pulse application [69,70].…”

Section: The Dw-mri Acquisitionmentioning

confidence: 96%

Application of multivariate image analysis to prostate cancer for improving the comprehension of the related physiological phenomena and the development and validation of new imaging biomarkers

Sarrió¹

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A doctoral thesis submitted to the Department of applied statistics, Operations Research and QualityThis journey started six years ago after finishing the last exams of my Master degree.In that summer of 2013 I was thinking about my future and how to orientate the Master's thesis. Truly, I had no idea on what to do, but Alberto Ferrer, after the presentation of my work for his subject, suggested me to have a meeting with José Manuel Prats where they showed me the interesting new approach of "our" methods to medical imaging they were working on. I got involved so easy in this world by their hand, and after all this time, they have been the best supervisors I could ever imagined. I learnt how to investigate; they taught me about the importance of knowing the process in detail before trying anything, to argue everything, to propose new ideas, the importance of the testing/validation, to give a measure of the reliability of the results and more, a bunch things that will make this list extremely long. Thank you so much, Alberto and José Manuel. A few more words for JM, he has been always there for me, in the best and worst moments, he is an amazing professor and better person. To my second supervisor Roberto Sanz, it was always a pleasure to work with him. The relation between these two worlds (university and hospital) is never easy, but he managed to go with us together in the same direction during this journey. Roberto, thank you for your dedication and hard work of giving us always the best data set you can, listening to our ideas and contributing with your valuable advices. I would like to thank Luís Martí Bonmatí for introducing us into this world and saving some time from his busy schedule for us, always in a kind way. I would also like to thank all the people from the Hospital Quirón, without their work and their images, this thesis wouldn't have been possible.To my office mates. Dani, we know each other for a long time and we have travelled a lot together, it was always nice to have him on the other side of the table. To Raffa and Abel for helping me and answering to all my questions. To Borja and Antonio for having good times discussing and arguing together. To Alba and Joan, we didn't share so much time but they are magnificent and very talented people.To my "all time" friends in my little village, Kike, Mode, Jorge, Javi, Toni, Carles, etc. for the long nights of just talking. To my friends in the city, Vicci and Rivera, we lived together 4 years and I got so many precious memories that will stay with me forever.And last, but not least, to my family, they always supported me, gave me their love and tried to charm me up when I felt bad. But also to celebrate when we succeed. Unfortunately, my "uelos" aren't with us anymore, I dedicate this work to them and hope they would have been proud of me. Thank you.

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Functional imaging of tumors. Part 1

Cited by 3 publications

References 55 publications

Metastatic Renal Cell Carcinoma: Radiologic Findings and Assessment of Response to Targeted Antiangiogenic Therapy by Using Multidetector CT

Metastatic Renal Cell Carcinoma: Radiologic Findings and Assessment of Response to Targeted Antiangiogenic Therapy by Using Multidetector CT

Mathematical Models of Contrast Transport Kinetics for Cancer Diagnostic Imaging: A Review

Application of multivariate image analysis to prostate cancer for improving the comprehension of the related physiological phenomena and the development and validation of new imaging biomarkers

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