Functional imaging of the human placenta with magnetic resonance

Siauve, Nathalie; Chalouhi, G. E.; Deloison, B.; Alison, Marianne; Clémеnt, Olivier; Ville, Y.; Salomon, Laurent

doi:10.1016/j.ajog.2015.06.045

Cited by 109 publications

(83 citation statements)

References 108 publications

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“…Our results for the control group were similar to those reported in the literature under normal conditions, with a mean placental blood flow of 140–149 mL/min/100 mL, in accordance with previous results obtained with DCE MRI [5-8, 13]. The fractional blood volume (46.7%) was also similar to those found in the literature [5-8, 13]. Our animal model was effective, with significantly lower fetal and placental weights for the L-NAME group than for controls.…”

Section: Discussionsupporting

confidence: 82%

“…Animal DCE MRI, the technique that we chose, has been recently used in studies to investigate pathological models [19, 23]. Placental perfusion has also been studied by techniques other than DCE in humans, such as arterial spin labeling and intravoxel incoherent motion [13]. Other functional MRI techniques, such as blood oxygenation level-dependent MRI, have been recently tested for the investigation of placental function [13].…”

Section: Discussionmentioning

confidence: 99%

“…Published results [4-7, 12, 13, 15-17] were used to calculate the sizes of the samples required to detect placental perfusion in L-NAME rats that is 20% lower than that in controls, using the Student t test for comparisons, with α and power set at 5 and 80%, respectively; at least 57 placentas in each group were required.…”

Section: Methodsmentioning

confidence: 99%

“…We considered the relationship between the gadolinium concentration and SI to be linear in the concentration range used [4, 5, 13]. …”

Section: Methodsmentioning

confidence: 99%

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Assessment of Placental Perfusion in the Preeclampsia L-NAME Rat Model with High-Field Dynamic Contrast-Enhanced MRI

et al. 2018

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Purpose: To evaluate placental function and perfusion in a rat model of preeclampsia infused with L-nitro-arginine methyl ester (L-NAME) by dynamic contrast-enhanced (DCE) MRI using gadolinium chelates. Methods: Pregnant female Sprague-Dawley rats were fitted on embryonic day 16 (E16) with subcutaneous osmotic minipumps loaded to deliver, continuously, L-NAME (50 mg/day per rat; case group) or saline solution (control group). DCE MRI was performed on E19 using gadolinium chelates and a 4.7-T MRI apparatus for small animals. Quantitative analysis was performed using an image software program: placental blood flow (perfusion in mL/min/100 mL of placenta) and fractional volume of the maternal vascular placental compartment (ratio between the placental blood volume and the placental volume, Vb in %) were calculated by compartmental analysis. Results: A total of 176 placentas (27 rats) were analyzed by DCE MRI (97 cases and 79 controls). The model was effective, inducing intrauterine growth retardation, as there was a significant difference between the two groups for placental weight (p < 0.01), fetal weight (p = 0.019), and fetal length (p < 0.01). There was no significant difference in placental perfusion between the L-NAME and control groups (140.1 ± 74.1 vs. 148.9 ± 97.4, respectively; p = 0.496). There was a significant difference between the L-NAME and control groups for Vb (53 ± 12.9 vs. 46.7 ± 9%, respectively; p < 0.01). Conclusion: In the L-NAME preeclampsia model, placental perfusion is normal and the fractional blood volume is increased, suggesting that preeclampsia is not always expressed as a result of decreased placental perfusion. This highlights the usefulness of MRI for investigating the physiopathology of preeclampsia.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…We considered the relationship between the gadolinium concentration and SI to be linear in the concentration range used [4, 5, 13]. …”

Section: Methodsmentioning

confidence: 99%

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Assessment of Placental Perfusion in the Preeclampsia L-NAME Rat Model with High-Field Dynamic Contrast-Enhanced MRI

et al. 2018

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“…ASL is a flow‐sensitive technique that relies on magnetically labeled water molecules to quantify blood flow in the placenta. MRS, as in any other organ in the body, can assess information regarding metabolites . An additional interesting approach of placental assessment has been fusion of ultrasound images on MRI, taking advantage of the ability of real‐time Doppler in assessing placental vascularity …”

Section: Mri Features Of Placental Abnormalitiesmentioning

confidence: 99%

MRI evaluation of the placenta from normal variants to abnormalities of implantation and malignancies

Zaghal

Hussain

Berjawi

2019

Magnetic Resonance Imaging

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Even though the placenta has been known for millennia, it is still considered one of the most complex and least understood human organs. Imaging of the placenta is gaining attention due to its impact on fetal and maternal outcomes. MRI plays a vital role in evaluation of inconclusive cases by ultrasonography. It enables precise mapping of placental abnormalities for proper multidisciplinary planning and management. In this article we provide a comprehensive in‐depth review of the role of antenatal MR in evaluating "The Placenta." We will describe the protocols and techniques used for MRI of the placenta, review anatomy of the placenta, describe MRI features of major placental abnormalities including those related to position, depth of implantation, hemorrhage, gestational trophoblastic neoplasia, and retained products of conception and discuss the added value of MRI in the management and preoperative planning of such abnormalities. Level of Evidence: 3 Technical Efficacy Stage: 5 J. Magn. Reson. Imaging 2019;50:1702–1717.

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Structurally Optimized Fluorinated Small‐Sized Graphene Oxide for Enhanced Magnetic Resonance Imaging during Pregnancy

Xu,

Chen,

Wang

et al. 2023

Adv Funct Materials

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Gadolinium‐based complex contrast agents (GBCAs), frequently applied in magnetic resonance imaging (MRI), are associated with severe acute anaphylactic shock and incurable nephrogenic systemic fibrosis. Besides, the repeated use of GBCAs may result in the accumulation in various tissues. Given these potential adverse effects, GBCAs have not been well used during pregnancy. Herein, a novel metal‐free T2‐weighted MRI nanoprobe, designated fluorinated small‐sized graphene oxide with optimized fluorine content (LF‐sGO), is developed via graphene oxide materials. By introducing specific polar C─F bonds onto the small‐sized graphene oxide (sGO) skeleton, the prepared nanoprobe exhibits excellent water solubility, as well as superior MRI capabilities, thereby furnishing high‐resolution MRI anatomical information. Furthermore, the free radicals on LF‐sGO stabilized by C─F bonds confer LF‐sGO enrichment in the tumor region, enabling comprehensive imaging capability. The cytotoxicity study in vitro indicates that LF‐sGO has the potential to serve as a biocompatible imaging probe. Moreover, detailed in vivo studies on pregnant mice and zebrafish adequately demonstrate that microinjection of LF‐sGO does not induce dysontogensis and teratogenesis. This study successfully showcases a metal‐free nanoprobe that exhibits exceptional MRI capabilities for the purpose of tumor diagnosis. Notably, this nanoprobe holds promise for safe and effective tumor diagnosis during pregnancy.

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Functional imaging of the human placenta with magnetic resonance

Cited by 109 publications

References 108 publications

Assessment of Placental Perfusion in the Preeclampsia L-NAME Rat Model with High-Field Dynamic Contrast-Enhanced MRI

Assessment of Placental Perfusion in the Preeclampsia L-NAME Rat Model with High-Field Dynamic Contrast-Enhanced MRI

MRI evaluation of the placenta from normal variants to abnormalities of implantation and malignancies

Structurally Optimized Fluorinated Small‐Sized Graphene Oxide for Enhanced Magnetic Resonance Imaging during Pregnancy

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