Functional imaging of head and neck cancers

Emonts, Patrick; Bourgeois, Pierre; Lemort, Marc; Flamen, Patrick

doi:10.1097/cco.0b013e32832a2322

Cited by 15 publications

(12 citation statements)

References 36 publications

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“…In bone, blood flow and blood volume values are very low (due to the histological type of tissue), and even visible disturbances in terms of osteosclerosis and osteolysis do not produce a noticeable change in any of the perfusion parameters. This was well illustrated during a separate analysis of mandibular and cartilaginous infiltration in the T4 group, and is also in line with previous reports [3,14] indicating that accurate evaluation of bone in terms of possible infiltration requires both CT and MR imaging.…”

Section: Discussionsupporting

confidence: 64%

“…For better evaluation of the extent of malignant tissue, a new tool of functional imaging has been introduced -CT perfusion. Starting from brain ischaemia and brain tumour evaluation [3], it quickly became an effective, reliable and accurate method for the assessment of neo-angiogenesis, which is typical for malignancy [9][10][11].…”

Section: Discussionmentioning

confidence: 99%

“…To date, MSCT with multi-planar reformations (MPR) has been widely used for preoperative staging of head and neck cancer, and its accuracy ranges from 43% to 89%, depending on the type of scanner [3][4][5][6]. Each tumour stage (T1-T4) has its own prognostic importance, but the preoperative prediction of T4 tumours is of particular significance in determining tumour resectability, optimal extent of surgery and concomitant chemoradiotherapy [4,7,8].…”

Section: Introductionmentioning

confidence: 99%

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Head and neck squamous cell cancer – the role of computed tomography enhanced with perfusion imaging in tumour staging

Trojanowska¹,

Trojanowski²,

Drop³

et al. 2011

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A Ai im m o of f t th he e s st tu ud dy y: : To determine the added value of computed tomography perfusion (CTP) images combined with contrast-enhanced computed tomography (CECT) images in staging of head and neck squamous cell cancer (SCC). M Ma at te er ri ia al l a an nd d m me et th ho od ds s: : Forty-seven consecutive patients with histologically proven squamous cell cancer of the head and neck and qualified for surgical treatment were prospectively evaluated in 2 groups: based on CECT multiplanar reformations (axial, coronal and sagittal), and separately, based on CTP images combined with CECT data. Tumour stage was assessed in each group separately, with special emphasis on T4 stage, and results were compared with histological findings. Five patients underwent endoscopic laser tumour resection, 11 underwent other tumour resection (glossectomy, pharyngectomy) and 31 patients underwent en-bloc resection of the hypopharynx and larynx, allowing detailed pathological evaluation of possible tumour infiltration into surrounding structures. Two experienced head and neck radiologists evaluated the images.Inter-observer agreement was tested with the modified κ test. The χ 2 test was applied to compare the number of correctly staged tumours for the two methods and readers. R Re es su ul lt ts s: : Inter-observer agreement was high (k = 0.88-0.90). Significant differences between the two groups were observed; with added CTP assessment more anatomical structures were rated positive for tumour infiltration and diagnostic accuracy of this method was significantly higher when compared to CECT images. Sole evaluation of CECT images in less advanced cases led to overestimation of the disease, since inflammation and slight oedema could not be differentiated from tumour. C Co on nc cl lu us si io on ns s: : Contrast-enhanced computed tomography multi-planar images enhanced with CTP images were proven to improve accuracy in head and neck cancer staging. The added value of CTP may help to avoid overestimation of the malignant process and at the same time may facilitate depiction all infiltrated structures.K Ke ey y w wo or rd ds s: : CT perfusion, squamous cell cancer, TNM, computed tomography.

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Head and neck squamous cell cancer – the role of computed tomography enhanced with perfusion imaging in tumour staging

Trojanowska¹,

Trojanowski²,

Drop³

et al. 2011

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“…However, evaluation of single anatomic images has some drawbacks, as early lesion detection remains difficult, and benign processes can mimic malignancies [5]. In many cases inflammatory response and edema cannot be differentiated from the tumor itself, which leads to over-interpretation and upstaging of the disease [5,6]. On the other hand, a pattern of infiltration not accompanied by visible anatomic distortion may result with lesion downstaging.…”

Section: Introductionmentioning

confidence: 99%

“…For better evaluation of tumor extent, dynamic scanning with perfusion imaging (CTP) has been introduced [5–9]. This technique, starting from brain ischemia and brain tumor evaluation, quickly became an effective, simple and reliable method for the assessment of neo-angiogenesis, which is typical for tumors [5,7,8,10].…”

Section: Introductionmentioning

confidence: 99%

Head and neck cancer: Value of perfusion CT in depicting primary tumor spread

et al. 2012

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SummaryBackgroundThe aim of this study was to assess head and neck squamous cell cancer and surrounding tissue in computed tomography contrast enhanced and perfusion studies, and to examine the role of perfusion imaging in depiction of tissue infiltration.Material/MethodsWe prospectively evaluated 43 primary malignant head and neck tumors, using standard CT followed by perfusion. Blood flow, blood volume, mean transit time, and permeability values were obtained using regions of interest (ROIs) over lesions and surrounding tissue. Results were compared with histological analysis of resected tissue. Sensitivity, specificity, accuracy, positive and negative predictive values were calculated for both methods.ResultsWe found significant differences between infiltrated and non-infiltrated tissue, especially with regard to muscles. In case of bone and salivary gland infiltration, change in perfusion parameters did not allow proper diagnosis.ConclusionsCTP shows promise in depicting malignant infiltration. The combined use of CECT plus CTP results in correct staging of the majority of head and neck tumors.

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Morbidity of supraomohyoidal and modified radical neck dissection combined with radiotherapy for head and neck cancer. A prospective longitudinal study

et al. 2011

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Functional imaging of head and neck cancers

Abstract: Functional imaging improves the initial staging and the detection of residual or recurrent disease following therapy.

Cited by 15 publications

References 36 publications

Head and neck squamous cell cancer – the role of computed tomography enhanced with perfusion imaging in tumour staging

Head and neck squamous cell cancer – the role of computed tomography enhanced with perfusion imaging in tumour staging

Head and neck cancer: Value of perfusion CT in depicting primary tumor spread

Morbidity of supraomohyoidal and modified radical neck dissection combined with radiotherapy for head and neck cancer. A prospective longitudinal study

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