Functional Imaging as a Predictor of Schizophrenia

Whalley, Heather C.; Simonotto, Enrico; Moorhead, William J.; McIntosh, Andrew M.; Marshall, Ian; Ebmeier, Klaus P.; Owens, David C.; Goddard, Nigel; Johnstone, Eve C.; Lawrie, Stephen M.

doi:10.1016/j.biopsych.2005.11.013

Cited by 94 publications

(69 citation statements)

References 42 publications

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“…46 Similarly, the anterior cingulate has been associated with impairments in emotional processing and higher executive performances (for a review see Baiano and colleagues 47 ). Previous fMRI studies have revealed abnormal anterior cingulate engagement in patients with first-episode psychosis, [48][49][50] patients at high genetic risk for psychosis 51,52 and in high-risk individuals. 10 A recent SDM voxel-based meta-analysis confirmed anterior cingulate (and insular) grey matter reductions in patients with first-episode psychosis, suggesting that the general salience network is abnormal from the early phases of disease.…”

Section: Discussionmentioning

confidence: 99%

Voxel-wise meta-analysis of fMRI studies in patients at clinical high risk for psychosis

Fusar‐Poli

2012

J Psychiatry Neurosci

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Section: Discussionmentioning

confidence: 99%

Voxel-wise meta-analysis of fMRI studies in patients at clinical high risk for psychosis

Fusar‐Poli

2012

J Psychiatry Neurosci

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“…Similar findings have been reported using physiological measures of visual processing. For example, a recent fMRI study of (unmedicated) high-risk subjects who became symptomatic demonstrated abnormal activation patterns in the visual cortex of these subjects compared with that of high-risk subjects who remained asymptomatic (Whalley et al, 2006). Further, deficits in ERPs elicited by magnocellularbiased stimuli have been observed in family members of schizophrenia probands (Yeap et al, 2006), suggesting that early visual processing deficits may serve as an endophenotype for the disorder.…”

Section: Discussionmentioning

confidence: 99%

Magnocellular Pathway Impairment in Schizophrenia: Evidence from Functional Magnetic Resonance Imaging

Martı́nez¹,

Hillyard²,

Hagler³

et al. 2008

J. Neurosci.

185

154

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Sensory processing deficits in schizophrenia have been documented for several decades, but their underlying neurophysiological substrates are still poorly understood. In the visual system, the pattern of pathophysiology reported in several studies is suggestive of dysfunction within the magnocellular visual pathway beginning in early sensory cortex or even subcortically. The present study used functional magnetic resonance imaging to investigate further the neurophysiological bases of visual processing deficits in schizophrenia and in particular the potential role of magnocellular stream dysfunction. Sinusoidal gratings systematically varying in spatial frequency content were presented to subjects at low and high levels of contrast to differentially bias activity in magnocellular and parvocellular pathways based on well established differences in neuronal response profiles. Hemodynamic responses elicited by different spatial frequencies were mapped over the occipital lobe and then over the entire brain. Retinotopic mapping was used to localize the occipital activations with respect to the boundaries of visual areas V1 and V2, which were demarcated in each subject. Relative to control subjects, schizophrenia patients showed markedly reduced activations to low, but not high, spatial frequencies in multiple regions of the occipital, parietal, and temporal lobes. These findings support the hypothesis that schizophrenia is associated with impaired functioning of the magnocellular visual pathway and further suggest that these sensory processing deficits may contribute to higher-order cognitive deficits in working memory, executive functioning, and attention.

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“…Neuroimaging findings have predicted recovery from depression 8 months later [Canli et al 2005], relapse in methamphetamine dependence [Paulus et al 2005], onset of psychosis in at-risk individuals [Koutsouleris et al 2009, Whalley et al 2006], response to drug treatment for depression [Chen et al 2007] and anxiety [Nitschke et al 2009] and for cognitive behavioral therapy (CBT) in schizophrenia [Kumari et al 2009]. Evoked-response potentials measured in newborns [Molfese et al 2001] and pre-reading children with familial risk of dyslexia [Maurer et al 2009] predicted language and reading scores years later.…”

Section: Biomarkers and Mental Disordersmentioning

confidence: 99%

Graph-based clinical diagnosis and prediction using multi-modal neuroimaging data

Klein¹,

Ghosh²

2016

RIO

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Functional Imaging as a Predictor of Schizophrenia

Cited by 94 publications

References 42 publications

Voxel-wise meta-analysis of fMRI studies in patients at clinical high risk for psychosis

Voxel-wise meta-analysis of fMRI studies in patients at clinical high risk for psychosis

Magnocellular Pathway Impairment in Schizophrenia: Evidence from Functional Magnetic Resonance Imaging

Graph-based clinical diagnosis and prediction using multi-modal neuroimaging data

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