Functional, Hierarchically Structured Poly(diacetylene)s via Supramolecular Self‐Assembly

Abstract

The supramolecular self-assembly of macromonomers may serve as a first step to prepare well-defined, highly functionalized, hierarchically structured, conjugated polymers. Functional diacetylene macromonomers equipped with an oligopeptide segment designed to promote self-assembly into parallel beta-sheet type structures and a polydisperse, aliphatic coil segment to prevent global ordering give rise to supramolecular polymers with a tubular double-helical quarternary structure in organic solution. These supramolecular polymers may then be converted into the corresponding poly(diacetylene)s by UV irradiation under retention of their hierarchical structure.

Polymer‐Peptide Block Copolymers – An Overview and Assessment of Synthesis Methods

“…The peptide induced aggregation lead to supramolecular polymers that were microns long, and this structure was retained when the diacetylene groups were cross‐linked by UV irradiation, leading to a backbone polymer with pendant peptides (Figure 14). 64–69…”

The influence of amino acid sequence on structure and morphology of polydiacetylene containing peptide fibres

“…The interesting structural properties combined with the relatively facile functionalization make PA bres attractive structures to study. 16,[41][42][43][44][45] Systematic studies on assemblies of diacetylene containing amphiphiles elucidated the effect of several molecular parameters on the polymerisability of diacetylenes and the resulting polydiacetylene (PDA) absorption. 14 These aspects have been well investigated for peptide amphiphiles consisting of an alkyl tail coupled to a peptide moiety.…”

A clickable, highly soluble oligopeptide that easily forms organogels

“…For efficient selfassembly in organic solvents, a tetrapeptide was estimated to be sufficient (17). Although the GAGA sequence was widely used with different materials to regulate their assembly behaviours (8, 15, 16, 18 -20), compared with L-valine, L-alanine was a weaker b-sheets former (21).…”

“…For example, a modified GAGA tetrapeptide which mimicked Bombix Mori silk showed poor solubility in most of organic solvents (15,16). Long alphatic chains (17) were needed to increase its solubility. This problem presents obstacles in utilising such oligopeptides to modify small molecules or macromolecules in large scale.…”