Functional hepatocellular regeneration in elderly patients undergoing hepatectomy

Abstract

Our results suggest that functional hepatocellular regeneration is early, fast and similar between elderly and younger patients. Thus, age alone, does not appear to represent an absolute contraindication to hepatectomy.

Evaluation of liver regeneration and post-hepatectomy liver failure after hemihepatectomy in patients with hepatocellular carcinoma

“…The growth ratio did not, however, depend on patient age (Supplementary Figure S2). Our results are consistent with previous work [29,30,32,35,36] showing that functional liver regeneration occurs early and rapidly in older and younger patients alike. At the same time, one study [37] found age to correlate inversely with early liver regeneration in patients undergoing major hepatectomy, and those authors concluded that massive blood loss should be avoided to ensure early liver regeneration in older patients [37].…”

Evaluation of liver regeneration after hemi-hepatectomy by combining computed tomography and post-operative liver function

“…Our study found that liver regeneration was not affected by age, which is consistent with previously published results [ 7 , 8 , 40 , 41 ]. Although age is a very important consideration when selecting candidates for liver surgery, our study concluded that liver regeneration in older patients was similar to that in younger patients undergoing the same surgery.…”

Mitochondrial bioenergetics boost macrophage activation, promoting liver regeneration in metabolically compromised animals

“…Only 8%–15% of patients undergoing hepatic resection are older than 70 years due to the increasing prevalence of comorbidities that confer a high surgical risk. [ 32 ] WT mice aged 15–17 months were treated with either siCtrl or siMCJ, and 24 h later, 70% Phx was performed. The mice were sacrificed 72 h after the procedure.…”