Functional group selectivity using fluoroform as a mobile phase for supercritical fluid chromatography

Abstract

Abstract. The eluotropic strength and chromatographic selectivity of fluoroform is

Gaining greater selectivity in the supercritical fluid extraction of digoxin from Digitalis lanata leaves

“…Additional evidence of hydrogen bonding has been reported by Blackwell and Schallinger (1994), as naphthalene with a hydroxyl group substituted in the 1-position exhibited a 50% decrease in the capacity factor (kЈ) with trifluoromethane compared to pure carbon dioxide. They attributed this observation to the ability of trifluoromethane to interact with the analyte via hydrogen bonding interaction, and concluded that other types of dipole interactions were less important, and that functional groups capable of interacting with trifluoromethane through hydrogen bonding were affected chomatographically to a greater extent than those which were polarizable, but unable to hydrogen bond.…”

Supercritical Fluid Chromatography and Extraction

“…Blackwell and Schallinger investigated the eluotropic strength and selectivity of fluoroform compared to CO 2 and CO 2 /methanol for the analysis of naphthalene derivatives. They found that fluoroform is much stronger than the other mobile phases at the same temperature and pressure but is weaker under the same reduced conditions (60). These authors also investigated hydrofluorocarbon and perfluorocarbon mobile phases.…”

Temperature effects on selectivity using carbon dioxide-based mobile phases on silica-based packed columns near the mixture critical point

“…[ [20][21][22]. Chimowitz, et al, have modeled this retention behavior in terms of the difference between the ideal heat of solution of the analyte in the mobile phase and the analyte heat of adsorption on the stationary phase using the following equation [15][16][17]:…”