Functional graphene oxide as cancer-targeted drug delivery system to selectively induce oesophageal cancer cell apoptosis

Jiang, Jie; Pi, Jiang; Jin, Hua; Cai, Jiye

doi:10.1080/21691401.2018.1492418

Cited by 39 publications

(20 citation statements)

References 38 publications

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“…Then, drug-loading and in vitro release were performed. The drug loading of ORI@MOF-5 is as high as 52.86% ± 0.59%, which is much higher than other types of drug delivery systems, such as gold nanoparticles [46] or graphene oxides [47]. In our previous study [48], ORI was loaded by MIL-53 (Fe), and the drug loading was less than 50% under the same calculation method.…”

Section: Discussionmentioning

confidence: 89%

Investigation of Metal-Organic Framework-5 (MOF-5) as an Antitumor Drug Oridonin Sustained Release Carrier

et al. 2019

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Oridonin (ORI) is a natural active ingredient with strong anticancer activity. But its clinical use is restricted due to its poor water solubility, short half-life, and low bioavailability. The aim of this study is to utilize the metal organic framework material MOF-5 to load ORI in order to improve its release characteristics and bioavailability. Herein, MOF-5 was synthesized by the solvothermal method and direct addition method, and characterized by Scanning Electron Microscopy (SEM), X-Ray Diffraction (XRD), Fourier Transform Infrared Spectrometer (FTIR), Thermogravimetric Analysis (TG), Brunauer–Emmett–Teller (BET), and Dynamic Light Scattering (DLS), respectively. MOF-5 prepared by the optimal synthesis method was selected for drug-loading and in vitro release experiments. HepG2 cells were model cells. MTT assay, 4′,6-diamidino-2-phenylindole (DAPI) staining and Annexin V/PI assay were used to detect the biological safety of blank carriers and the anticancer activity of drug-loaded materials. The results showed that nano-MOF-5 prepared by the direct addition method had complete structure, uniform size and good biocompatibility, and was suitable as an ORI carrier. The drug loading of ORI@MOF-5 was 52.86% ± 0.59%. The sustained release effect was reliable, and the cumulative release rate was about 87% in 60 h. ORI@MOF-5 had significant cytotoxicity (IC50:22.99 μg/mL) and apoptosis effect on HepG2 cells. ORI@MOF-5 is hopeful to become a new anticancer sustained release preparation. MOF-5 has significant potential as a drug carrier material.

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Section: Discussionmentioning

confidence: 89%

Investigation of Metal-Organic Framework-5 (MOF-5) as an Antitumor Drug Oridonin Sustained Release Carrier

et al. 2019

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“…Jiao et al [5] loaded different amounts of drugs on carboxy-methyl cellulose-grafted graphene oxide, and high drug-loading efficiency and encapsulation efficiency were achieved, which could reach 39.33% and 29.50%. Innovative nano-drug (Ori@GE11-GO) was prepared to recognize the specific tumour cells, and improve anticancer efficiency [6]. Graphene-based substrates was applied as adsorbent and photocatalyst to remove oil and organic/inorganic contaminants [7].…”

Section: Introductionmentioning

confidence: 99%

The multiscale enhancement of mechanical properties of 3D MWK composites via poly(oxypropylene) diamines and GO nanoparticles

Zuo

Hui

et al. 2019

Nanotechnology Reviews

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Interfacial bonding between the fibers and matrix plays a large role in mechanical properties of composites. In this paper, poly(oxypropylene) diamines (D400) and graphene oxide (GO) nanoparticles were grafted on the desized 3D multi axial warp knitted (MWK) glass fiber (GF) fabrics. The surface morphology and functional groups of modified glass fibers were characterized by scanning electron microscopy (SEM) and fourier transform infrared spectra (FT-IR). Out-of-plane compression properties and the failure mechanisms of composites at different temperature were tested and analyzed. The results revealed that GO nanoparticles were successfully grafted on fibers under the synergistic effect of D400. In addition, D400-GO-grafted composite possessed the highest mechanical properties than desized composite and GO-grafted composite. Their strength and modulus were improved by 10.16%, 10.06%, 8.92%, 8.75%, 7.76% and 40.38%, 32.74%, 29.85%, 26.98%, 25.16% compared to those of desized composites at 30∘C, 60∘C, 90∘C, 120∘C, 150∘C, respectively. The damage to D400-GO-grafted composite was yarns fracture accompanied with fibers breakage, matrix cracking, interface debonding. At higher temperature, interlayer slipping with matrix plasticization was the main failure mode.

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“…Moreover, some charged polysaccharides such as chitosan, hyaluronic acid, and chondroitin sulfate could have interactions with oppositely charged drug molecules, which could also help to control drug loading and releasing [5,18]. Additionally, graphene family materials have a conjugated structure, which can absorb drug molecule through π-π interactions [18,[23][24][25][26][27][28]. Moreover, the oxygen permeability of CS film had been confirmed by previous research [29].…”

Section: Introductionmentioning

confidence: 60%

A Facile Route to Fabricate CS/GO Composite Film for the Application of Therapeutic Contact Lenses

Chen

Wang

Kong

et al. 2020

Advances in Materials Science and Engineering

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Traditional contact lenses bring convenience for ophthalmic drug delivery. However, either as contact lenses or as drug carriers, traditional materials have still some drawbacks in the field. Therefore, a transparent film was designed and investigated for the application of therapeutic contact lenses. Chitosan (CS)/graphene oxide (GO) composite film and CS film were fabricated with acceptable transparent and tensile properties by simple casting flow method. Although swelling ratio of CS/GO composite film was higher than that of CS film with significant difference, both formed films had suitable swelling ratio for contact lens application. Both CS/GO composite film and CS film exhibited typical CS infrared characteristic peaks. CS/GO composite film had significant greater breaking strength than CS film, but its elongation at break was a little lower than CS film. Either CS/GO composite film or CS film exhibited good hydrophilic property with a contact angle of around 20 degree. Ofloxacin as a model drug was loaded into films by adsorption diffusion method. Loaded drug amount in CS/GO composite film was a little larger than that in CS film, but without significant difference. The drug release behaviors from CS/GO composite film or CS film were investigated and revealed that the loaded drug could be controlled to release in the first hour. Two kinds of cells were used to evaluate the biocompatibility of films by in vitro method. It was found that both CS/GO composite film and CS film could support human umbilical vein endothelial cell (HUVEC) growth. But for human epidermal fibroblasts (HSF) cells, CS/GO composite film could promote HSF cells growth and proliferation much better than CS film.

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Functional graphene oxide as cancer-targeted drug delivery system to selectively induce oesophageal cancer cell apoptosis

Cited by 39 publications

References 38 publications

Investigation of Metal-Organic Framework-5 (MOF-5) as an Antitumor Drug Oridonin Sustained Release Carrier

Investigation of Metal-Organic Framework-5 (MOF-5) as an Antitumor Drug Oridonin Sustained Release Carrier

The multiscale enhancement of mechanical properties of 3D MWK composites via poly(oxypropylene) diamines and GO nanoparticles

A Facile Route to Fabricate CS/GO Composite Film for the Application of Therapeutic Contact Lenses

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