Functional genomics reveals the mechanism of hypoxic adaptation in nontuberculous mycobacteria
Yoshitaka Tateishi,
Yuriko Ozeki,
Akihito Nishiyama
et al.
Abstract:Mycobacterium intracellulareis a major etiological agent of the recently expandingMycobacterium avium–intracellularecomplex pulmonary disease (MAC-PD). Therapeutic regimens that include a combination of macrolides and antituberculous drugs have been implemented with limited success. To identify novel targets for drug development that accommodate the genomic diversity ofM. avium–intracellulare, we subjected eight clinical MAC-PD isolates and the type strain ATCC13950 to genome-wide profiling to comprehensively … Show more
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