Functional genomics reveals an off-target dependency of drug synergy in gastric cancer therapy
Ozen Leylek,
Megan E. Honeywell,
Michael J. Lee
et al.
Abstract:The rational combination of anticancer agents is critical to improving patient outcomes in cancer. Nonetheless, most combination regimens in the clinic result from empirical methodologies disregarding insight into the mechanism of action and missing the opportunity to improve therapy outcomes incrementally. Deciphering the genetic dependencies and vulnerabilities responsible for synergistic interactions is crucial for rationally developing effective anticancer drug combinations. Hence, we screened pairwise pha… Show more
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