Functional genomics of abiotic environmental adaptation in lacertid lizards and other vertebrates

Abstract

and is available as an interactive resource at: www.cassandra-genes.org. A network cytoscape session with the vertebrate network as well as the ClueGo results is available at doi:10.6084/m9.figshare.15010872. Code is provided in the Supplementary Materials as Supplementary Appendix 1.

Life on the edge: a new toolbox for population-level climate change vulnerability assessments

“…Furthermore, different kinds of 'omics data (e.g. structural variants such as copy number variants or epigenetic data) could broaden the approach to investigate other types of genomic variants that influence adaptive responses (Layton & Bradbury, 2022;Wollenberg Valero et al 2022), especially when available from multiple individuals and populations across a species' range.…”

Environmental factors influence cross-talk between a heat shock protein and an oxidative stress protein modification in the lizard Gallotia galloti

“…Squamate reptiles are vulnerable to climate change, with extinction rates accelerating [35][36][37][38][39], and their capacity to adapt remains unclear [40][41][42][43]. Among these, lizards provided an early model for linking behavioural thermoregulation to physiology and performance [44][45][46] and remain relevant as a model to investigate adaptation to different environmental conditions at the molecular level [47]. For example, to link ectotherm thermoregulation to the environmental thermal profile, the operative temperature (T e ) can be calculated, which estimates a steady-state body temperature based on available microclimates according to a biophysical model [48].…”

“…These are often accompanied by trade-offs, like to fitness [57][58][59], and are subject to differential evolvability [60]. However, the molecular basis of how adaptation to environmental optima is achieved, is less explored [47]. Gallotia galloti is a basal lacertid lizard endemic to the Canary Islands (Spain).…”

Network architecture of transcriptomic stress responses in zebrafish embryos

“…For instance, warm temperatures during embryonic development caused later-life effects on the transcriptomic network organization in laboratory lines of multiple fish species, including zebrafish, increasing its network entropy (Scott and Johnston 2012; Ripley et al 2023). The stress response is regarded to be adaptive, and depending on the organism and the type of stress, can either be generically shared by multiple stressors or be specific to a particular stressor (de Nadal, Ammerer, and Posas 2011; Wollenberg Valero et al 2022). Any stressor-specific response may trigger deleterious trade-offs within multiple stressor environments, which is why the general stress response is thought to have an evolutionary conserved component (de Nadal, Ammerer, and Posas 2011; Burton et al 2021).…”

“…Genetic networks are often used in human research (Rual et al 2005; Luck et al 2020). Additional studies have focused on network evolution in fungi (Joy et al 2005; Usaj et al 2017; Lorena Ament-Velásquez et al 2022; Wollenberg Valero 2020) and bacteria (Philippe et al 2007; Crombach and Hogeweg 2008), with very few studies pertaining to vertebrate animals (but see (Wollenberg Valero et al 2014, 2022) for examples of climate adaptation-related networks). However, a few general patterns are emerging; such as that of genes towards the center of the network being most highly conserved, and those positioned intermediately having the highest number of connections with other nodes, whereas both constraint and pleiotropy are lowest at the network periphery (also see (Wollenberg Valero 2024).…”