Functional genomics and proteomics: application in neurosciences

Wilson, Karen E.

doi:10.1136/jnnp.2003.026260

Cited by 72 publications

(9 citation statements)

References 92 publications

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“…The hypothesis that premorbid personality traits may be related with cognitive decline was confirmed by a number of previous studies [13,14,15,17,22,23,34]. Proneness to psychological distress measured by items of the neuroticism scale of the NEO Five-Factor Personality Inventory was associated with a higher risk of AD independently of pathological markers of AD, a finding suggesting that in these patients less AD pathology might be needed to reach the clinical threshold of dementia [19].…”

Section: Discussionsupporting

confidence: 53%

“…However, changes of premorbid personality traits were evaluated in patients with cognitive decline [14,15,16,17,18,19,20]. Premorbid proneness to experience psychological distress has been related to the level of impairment in episodic memory in persons with AD [15]. Increased rigidity or egocentrism, growing apathy and impaired emotional control have been described in patients developing dementia [16].…”

Section: Introductionmentioning

confidence: 99%

“…Among the different personality models, dimensional approaches of personality, such as the Five-Factor Model, assess personality traits independently of their normal or pathological significance and are well suited for studies not primarily focussing on personality pathology. However, changes of premorbid personality traits were evaluated in patients with cognitive decline [14,15,16,17,18,19,20]. Premorbid proneness to experience psychological distress has been related to the level of impairment in episodic memory in persons with AD [15].…”

Section: Introductionmentioning

confidence: 99%

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Personality Traits and Behavioural and Psychological Symptoms in Patients with Mild Cognitive Impairment

Rubio¹,

Antonietti

Donati³

et al. 2013

Dement Geriatr Cogn Disord

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Background and Aims: Both personality changes and behavioural and psychological symptoms (BPS) may be associated with mild cognitive impairment (MCI) in later life and help identify incipient dementia. We wished to investigate the links between personality and BPS in MCI. Method: We studied premorbid personality traits as estimated 5 years back and their changes in 83 control subjects and 52 MCI patients using the revised NEO Personality Inventory for the Five-Factor Model completed by a proxy. Information on BPS was obtained using the Neuropsychiatric Inventory (NPI). Analyses were controlled for current depression and anxiety. Results: Premorbid neuroticism and openness to experience were associated with the total NPI score. The changes in neuroticism, extraversion, openness to experiences, and conscientiousness were associated with apathy and affective symptoms. Conclusions: Personality changes and BPS occur in MCI. The occurrence of affective BPS and apathy is associated with both premorbid personality traits and their changes.

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Section: Discussionsupporting

confidence: 53%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Personality Traits and Behavioural and Psychological Symptoms in Patients with Mild Cognitive Impairment

Rubio¹,

Antonietti

Donati³

et al. 2013

Dement Geriatr Cogn Disord

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“…Higher neuroticism is related to poorer performance on a number of cognitive measures which might reflect the effect of chronic distress on cognitive ageing [8]. There is also evidence that a premorbid proneness to experience psychological distress is associated with the level of impairment in episodic memory in AD subjects but not with the disease progression [9]. Persons prone to distress show a 2.7 times higher risk of developing AD as well as a more rapid cognitive decline compared to persons not prone to distress [10].…”

Section: Introductionmentioning

confidence: 99%

Premorbid Personality Traits and Their Course in Mild Cognitive Impairment: Results from a Prospective Population-Based Study in Germany

Kuźma¹,

Sattler²,

Toro³

et al. 2011

Dement Geriatr Cogn Disord

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Background: Personality traits contribute to cognitive functioning. We present a study comparing personality traits in normal ageing and mild cognitive impairment (MCI). Methods: We conducted a representative longitudinal study including 222 subjects from a cohort born between 1930 and 1932 (n = 500) examined at three examination waves (t1: 1993/1994; t2: 1997/1998; t3: 2005/2007). Personality traits were assessed with the NEO-Five-Factor Inventory questionnaire. Results: Healthy controls and patients with MCI showed a significant (p < 0.05) decrease concerning their levels of neuroticism and extraversion over time. MCI subjects scored significantly higher on neuroticism at baseline and lower on openness at all examinations compared to healthy controls. Subjects with higher baseline neuroticism showed a 2.24 times higher risk of developing MCI at the third follow-up (odds ratio = 2.24, 95% confidence interval = 1.12–4.45 – scores adjusted for education and sex). Conclusions: MCI subjects differ in their premorbid personality traits compared to healthy controls. According to our study, higher neuroticism should be considered a risk factor for the development of MCI.

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“…As cognitive deficits are common in patients with psychiatric symptoms [20,21,22], we hypothesized that psychiatric symptoms are associated with an increased risk of subsequent cognitive decline.…”

Section: Introductionmentioning

confidence: 99%

The Association between Psychiatric and Cognitive Symptoms after Stroke: A Prospective Study

2005

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Background: Stroke patients often have neuropsychiatric symptoms and cognitive deficits. The aim of this study was to investigate whether stroke patients with psychiatric symptoms are at increased risk of developing cognitive deficits. Methods: Cognitive function (assessed with a neuropsychological test battery) and presence of psychiatric symptoms (assessed with the 90-item Symptom Checklist) were evaluated at 1, 6, 12 and 24 months after stroke. Results: At baseline, 156 patients entered the study, 15 had a diagnosis of vascular dementia, 113 one of post-stroke mild cognitive impairment. Patients with psychiatric symptoms were found to be at increased risk of being diagnosed as having vascular dementia at baseline (OR = 6.9, CI = 1.3–36.8) and showed more decline on cognitive function 6 months after stroke. Conclusions: Patients with psychiatric symptoms after stroke are at increased risk of cognitive deficits and decline in cognitive functioning.

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Functional genomics and proteomics: application in neurosciences

Cited by 72 publications

References 92 publications

Personality Traits and Behavioural and Psychological Symptoms in Patients with Mild Cognitive Impairment

Personality Traits and Behavioural and Psychological Symptoms in Patients with Mild Cognitive Impairment

Premorbid Personality Traits and Their Course in Mild Cognitive Impairment: Results from a Prospective Population-Based Study in Germany

The Association between Psychiatric and Cognitive Symptoms after Stroke: A Prospective Study

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