Margaret B. Wierman, Mirela Matecic, Veena Valsakumar, Mingguang Li, Daniel L. Smith, Stefan Bekiranov, Jeffrey S. Smith
Abstract:Yeast chronological lifespan (CLS) is extended by multiple genetic and environmental manipulations, including caloric restriction (CR). Understanding the common changes in molecular pathways induced by such manipulations could potentially reveal conserved longevity mechanisms. We therefore performed gene expression profiling on several long-lived yeast populations, including an ade4∆ mutant defective in de novo purine (AMP) biosynthesis, and a calorie restricted WT strain. CLS was also extended by isonicotinam…
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