Functional genetic variant in the Kozak sequence of WW domain-containing oxidoreductase (WWOX) gene is associated with oral cancer risk

Cheng, Hong; Liu, Yu-Fan; Su, Chung‐Kuang; Su, Shih‐Chi; Chen, Mu‐Kuan; Yang, Shun‐Fa

doi:10.18632/oncotarget.12082

Cited by 26 publications

(24 citation statements)

References 53 publications

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“…High expression of MACC1 was also found in lung [20], breast [21], ovarian [22] and cervical cancers [7]. The genetic polymorphisms may affect the promoter activity and gene expression, therefore SNPs probably display influences on the tumor growth, invasion or metastasis such as breast, ovarian and oral cancers [12,[23][24][25][26][27][28][29][30][31][32]. The MACC1 SNP rs975263 (S515L), which is a nonsynonymous SNP exchanging serine to leucine, is situated at codon 515 in exon 5.…”

Section: Discussionmentioning

confidence: 99%

Investigation of metastasis-associated in colon cancer-1 genetic variants in the development and clinicopathologcial characteristics of uterine cervical cancer in Taiwanese women

Sun

Chou

et al. 2020

Int. J. Med. Sci.

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The objectives of this study were to define the associations among single nucleotide polymorphisms (SNPs) of metastasis-associated in colon cancer-1 (MACC1) gene, development and clinicopathological characteristics of uterine cervical cancer, and patient survival in Taiwan. Genotypic frequencies of 5 MACC1 SNPs rs975263, rs3095007, rs4721888, rs3735615 and rs1990172 were identified for 132 patients with invasive cancer, 99 with high-grade cervical intraepithelial neoplasia and 338 normal controls using real-time polymerase chain reaction. It revealed that there were no associations of these MACC1 SNPs with cervical carcinogenesis. In the meantime, cervical cancer patients with genotype GG in MACC1 SNP rs975263 tended to display more risk to have vaginal invasion than those with AA/AG (p=0.042, OR: 8.70, 95% CI: 0.81-433.22). In multivariate analysis, positive pelvic lymph node metastasis could significantly predict worse 5 years survival rate (p=0.001; HR=9.98, 95% CI=2.64-37.77) for cervical cancer patients. In conclusion, pelvic lymph node status rather than MACC1 SNPs was the only independent parameter that could significantly predict 5 years survival rate in Taiwanese women with cervical cancer.

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Section: Discussionmentioning

confidence: 99%

Investigation of metastasis-associated in colon cancer-1 genetic variants in the development and clinicopathologcial characteristics of uterine cervical cancer in Taiwanese women

Sun

Chou

et al. 2020

Int. J. Med. Sci.

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“…Recently, in Taiwan, the prevalence of oral cancer in men has significantly increased, which may be attributed to the increase in betel nut chewing. 33 More than two million people in Taiwan are estimated to chew betel nut habitually, and 80% of oral cancer mortality was related to this habit. The 5-year survival rate of patients with OSCC is 25%, 34 which is lower than that of patients with breast and colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effects of Leucaena leucocephala on the metastasis and invasion of human oral cancer cells

Chung

Chen

Chang

et al. 2017

Environmental Toxicology

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Oral cancer is one of the most common cancers worldwide, and metastasis is recognized as a major factor causing its low survival rate. The inhibition of metastasis progress and the improvement of the survival rate for oral cancer are critical research objectives. Leucaena leucocephala from the mimosa branch Leucaena genus is native to Central and South America and has been used as a traditional remedy for treating various disorders. Previous studies have demonstrated antioxidant, anti-inflammatory as well as anticancer properties of L. leucocephala plant materials. However, the molecular mechanism underlying the anticancer effect induced by L. leucocephala remains unclear. In this study, we investigated the effect of L. leucocephala extract (LLE) on SCC-9 and SAS oral cancer cells and examined the potential inhibitory mechanisms involved. The results indicated that LLE attenuated the migration and invasion abilities of both SCC-9 and SAS cells by reducing the activity and protein expression of matrix metalloproteinases-2 (MMP-2). Regarding mitogen-activated protein kinase (MAPK) pathways, the phosphorylation of ERK1/2 and p38 exhibited a significant inhibitory effect in the presence of LLE. The application of ERK inhibitor and p38 inhibitor confirmed that both signalling transduction pathways were involved in the inhibition of cell metastasis. These data indicate that L. leucocephala could be a potent therapeutic agent for the prevention and treatment of oral cancer and a prominent plant source for anticancer research in the future.

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“…The most well‐known malignancy is oral squamous cell carcinoma (OSCC), accounting for more than 90% of oral cancer cases . OSCC has a poor prognosis and low 5 year survival rate (<50%) due to its critically metastatic and invasive nature …”

Section: Introductionmentioning

confidence: 99%

Antimetastatic effects ofRheum palmatumL. extract on oral cancer cells

Chen

Hsieh

et al. 2017

Environmental Toxicology

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Rheum palmatum L., a traditional Chinese medication, has been used for the treatment of various disorders. However, the detailed impacts and underlying mechanisms of R. palmatum L. extracts (RLEs) on human oral cancer cell metastasis are still unclear. Here, we tested the hypothesis that an RLE has antimetastatic effects on SCC-9 and SAS human oral cancer cells. Gelatin zymography, Western blot, real-time polymerase chain reaction, and luciferase assay were used to explore the underlying mechanisms involved in the antimetastatic effects on oral cancer cells. Our results revealed that the RLE (up to 20 μg/mL, without cytotoxicity) attenuated SCC-9 and SAS cell motility, invasiveness, and migration by reducing matrix metalloproteinase (MMP)-2 enzyme activities. Western blot analysis of the MAPK signaling pathway indicated that the RLE significantly decreased phosphorylated ERK1/2 levels but not p38 and JNK levels. In conclusion, RLEs exhibit antimetastatic activity against oral cancer cells through the transcriptional repression of MMP-2 via the Erk1/2 signaling pathways. Thus, RLEs may be potentially useful as antimetastatic agents for oral cancer chemotherapy.

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Functional genetic variant in the Kozak sequence of WW domain-containing oxidoreductase (WWOX) gene is associated with oral cancer risk

Cited by 26 publications

References 53 publications

Investigation of metastasis-associated in colon cancer-1 genetic variants in the development and clinicopathologcial characteristics of uterine cervical cancer in Taiwanese women

Investigation of metastasis-associated in colon cancer-1 genetic variants in the development and clinicopathologcial characteristics of uterine cervical cancer in Taiwanese women

Inhibitory effects of Leucaena leucocephala on the metastasis and invasion of human oral cancer cells

Antimetastatic effects ofRheum palmatumL. extract on oral cancer cells

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