Functional Gastrointestinal Disorders in Mediterranean Countries According to Rome IV Criteria

Strisciuglio, Caterina; Cenni, Sabrina; Serra, Maria Rosaria; Dolce, Pasquale; Kolaček, Sanja; Sila, Sara; Trivić, Ivana; Lev, Michal Rozenfeld Bar; Shamir, Raanan; Kostovski, Aco; Papadopoulou, Alexandra; Roma, Elefthería; Katsagoni, Christina N.; Jojkić-Pavkov, Danijela; Salvatore, Silvia; Pensabene, Licia; Scarpato, Elena; Miele, Erasmo; Staiano, Annamaria

doi:10.1097/mpg.0000000000003358

Cited by 11 publications

(13 citation statements)

References 43 publications

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“…One study, conducted among schoolchildren aged 10 to 18 years in Colombia, found that the R4PDQ had a sensitivity of 75% and a specificity of 90%, suggesting that the R4PDQ has adequate diagnostic accuracy for diagnosing DGBIs in children [ 40 ]. Recently, Strisciuglio C. et al [ 41 ] used the R4PDQ to assess the prevalence of DGBIs among children and adolescents in Mediterranean countries. This was a key methodological aspect of their research, allowing for a standardized assessment of DGBIs according to the latest diagnostic criteria.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Rome IV Pediatric Diagnostic Questionnaire-Assessed Disorder of Gut–Brain Interaction, Psychopathological Comorbidities and Consumption of Ultra-Processed Food in Pediatric Anorexia Nervosa

Rurgo,

Marchili,

Spina

et al. 2024

Nutrients

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Anorexia nervosa (AN) is a severe eating disorder primarily affecting children and adolescents. Disorders of the gut–brain interaction (DGBIs) have gained recognition as significant symptoms in individuals with AN. However, limited studies have explored GI symptoms in pediatric populations with AN using age-specific diagnostic tools. This study aims to investigate the prevalence of DGBIs, their associated psychopathological aspects and their potential correlations with ultra-processed food (UPF) consumption among pediatric AN patients. The study included AN patients who were under the care of a specialized multidisciplinary team. We assessed DGBI-related symptoms using the Rome IV Pediatric Diagnostic Questionnaire on Functional Gastrointestinal Disorders (R4PDQ) and conducted psychological evaluations. Dietary intake and UPF consumption were evaluated. Among 56 AN patients, we observed a lower prevalence of DGBIs (functional constipation: 61%; functional dyspepsia: 54%; irritable bowel syndrome: 25%) compared to the existing literature. The psychological assessments revealed high rates of depression (72%) and anxiety (70%). UPF consumption was inversely related to depression levels (p = 0.01) but positively correlated with functional constipation (p = 0.046). This study highlights the importance of using age-specific diagnostic tools and emphasizes the crucial role of a specialized multidisciplinary team in the treatment of AN.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Rome IV Pediatric Diagnostic Questionnaire-Assessed Disorder of Gut–Brain Interaction, Psychopathological Comorbidities and Consumption of Ultra-Processed Food in Pediatric Anorexia Nervosa

Rurgo,

Marchili,

Spina

et al. 2024

Nutrients

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“…This study was approved by the Ethics Committees of the coordinating center (University of Campania “Luigi Vanvitelli” of Naples) and of the other participating centers, and was conducted in accordance with the Declaration of Helsinki and Guidelines for Good Clinical Practice (registration number 2018/685). All data were collected anonymously and were entered into a Microsoft Excel database specifically designed for a previous study [ 11 ].…”

Section: Methodsmentioning

confidence: 99%

“…We used the Rome IV Diagnostic Questionnaire on Pediatric Functional Gastrointestinal Disorders (R4PDQ), specifically designed to diagnose FGIDs in children and adolescents [ 12 ]. R4PD has been translated for non-English-speaking countries, validated and approved by the Rome Foundation as described in our previous work [ 11 ].…”

Section: Methodsmentioning

confidence: 99%

Diet and Pediatric Functional Gastrointestinal Disorders in Mediterranean Countries

et al. 2022

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Background: The increased intake of FODMAP (fermentable oligosaccharides, disaccharides, monosaccharides, and polyol) rich foods has been suggested as a possible trigger of functional gastrointestinal disorders (FGIDs). Despite the high FODMAP content, the Mediterranean diet (MD) appears to have beneficial effects on health. Our aim was to evaluate whether the prevalence of FGIDs in different Mediterranean countries may be influenced by FODMAP consumption and adherence to the MD. Methods: A school-based, cross-sectional, multicenter study was performed in six countries in the Mediterranean area: Croatia, Greece, Israel, Italy, Macedonia, and Serbia. Subjects 4-18 years were examined in relation to their eating habits and the presence of FGIDs, using Rome IV criteria, 3-day food diaries and Mediterranean Diet Quality Index in Children and Adolescents (KIDMED) questionnaires. Results: We enrolled 1972 subjects between 4 and 9 years old (Group A), and 2450 subjects between 10 and 18 years old (Group B). The overall prevalence of FGIDs was 16% in Group A and 26% in Group B. FODMAP intake was significantly different among countries for both age groups. In both groups, no significant association was found between FGIDs and FODMAPs. Adherence to the MD in all countries was intermediate, except for Serbia, where it was low. In both groups, we found a statistically significant association between FGIDs and the KIDMED score (Group A: OR = 0.83, p < 0.001; Group B: OR = 0.93, p = 0.005). Moreover, a significant association was found between the KIDMED score and functional constipation (Group A: OR = 0.89, p = 0.008; Group B: OR = 0.93, p = 0.010) and postprandial distress syndrome (Group A: OR = 0.86, p = 0.027; Group B: OR = 0.88, p = 0.004). Conclusions: Our data suggest that the prevalence of FGIDs in the Mediterranean area is not related to FODMAP consumption, whereas adherence to the MD seems to have a protective effect.

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“…Most studies were performed in single countries, bar one global epidemiology study across 26 countries in adults, 18 one study of adults across Great Britain, 30 one study performed in schools across different Latin American countries, 33 and two performed in schools across different Mediterranean countries. 29,31 The pooled prevalence of rumination syndrome in all children (0-18 years) according to Rome III criteria was 1.0% (95% CI 0.3-1.6; I 2 = 91.1%) from 18 studies. 7,8,10,11,13,14,17,19,20,[22][23][24]26,27,29,32,33,35 There was significant heterogeneity with evidence of funnel plot asymmetry (Egger's test, p = 0.001).…”

Section: Re Sultsmentioning

confidence: 99%

The prevalence of rumination syndrome and rumination disorder: A systematic review and meta‐analysis

Haworth,

Treadway,

Hobson

2024

Neurogastroenterology Motil

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BackgroundRumination is characterized by the repeated regurgitation of food. Rumination syndrome is a disorder of gut‐brain interaction diagnosed by Rome criteria, whereas rumination disorder is a feeding and eating disorder diagnosed by DSM‐5 criteria. We aimed to determine the global prevalence of rumination according to these criteria across all age groups.MethodsWe performed a systematic review and meta‐analysis of studies reporting the prevalence of rumination syndrome according to Rome III and Rome IV and rumination disorder according to the following validated DSM‐5 assessments: PARDI, EDA‐5, EDY‐Q, STEP, and STEP‐CHILD. We searched MEDLINE, EMBASE, and PsychINFO (from January 1, 2006, to June 1, 2023) to identify studies reporting the prevalence of rumination in community settings in participants of any age. We did a meta‐analysis to estimate the pooled prevalence and odds ratio (OR) of rumination according to diagnostic criteria, country, and characteristics such as age and sex.Key ResultsThe search strategy generated 1243 studies, of which 147 studies appeared to be relevant. Thirty studies were included, with a total of 114,228 participants, of whom 61,534 of these were adults and 52,694 were children. The pooled prevalence of rumination syndrome in children of all ages according to Rome III criteria was 1.0% (95% CI 0.3–1.6; I2 91.1%), but no data were available for adults. According to Rome IV criteria, the pooled prevalence of rumination syndrome in children of all ages was 0.4% (95% CI 0.2–0.6; I2 56.4%) and 3.7% in adults (95% CI 2.3–5.1; I2 91.4%). The pooled prevalence of rumination disorder in children of all ages according to EDY‐Q was 2.1% (95% CI 0.9–3.4; I2 = 78.1%), but only one study utilizing EDY‐Q in adults was included (0.7% [95% CI 0.4–1.0]). No data were available for children or adults using any other validated DSM‐5 assessments for rumination disorder. Irrespective of diagnostic criteria, the pooled prevalence of rumination was higher in adults compared to children and adolescents (3.0% [95% CI 1.4–4.7; I2 = 98.1%] vs. 0.8% [95% CI 0.4–1.3; I2 = 90.8%]), but higher in adolescents than in children (1.1% [95% CI 0.3–2.0; I2 = 92.8%] vs. 0.1% [95% CI 0.0–0.2; I2 = 24.5%]). In adults, factors independently associated with rumination were female gender (OR 1.4 [95% CI 1.0–2.0]), anxiety (OR 2.3 [95% CI 2.1–2.6]), and depression (OR 1.8 [95% CI 1.2–2.9]). No association between gender and rumination was seen in children.Conclusions and InferencesThe prevalence of rumination is more common in adults than in children. In adults, rumination is associated with female gender, anxiety, and depression. Future population studies should aim to better understand why this behavior is more common in adults and also compare validated DSM‐5 assessments for rumination disorder with Rome criteria for rumination syndrome as prevalence may differ.

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Functional Gastrointestinal Disorders in Mediterranean Countries According to Rome IV Criteria

Cited by 11 publications

References 43 publications

Prevalence of Rome IV Pediatric Diagnostic Questionnaire-Assessed Disorder of Gut–Brain Interaction, Psychopathological Comorbidities and Consumption of Ultra-Processed Food in Pediatric Anorexia Nervosa

Prevalence of Rome IV Pediatric Diagnostic Questionnaire-Assessed Disorder of Gut–Brain Interaction, Psychopathological Comorbidities and Consumption of Ultra-Processed Food in Pediatric Anorexia Nervosa

Diet and Pediatric Functional Gastrointestinal Disorders in Mediterranean Countries

The prevalence of rumination syndrome and rumination disorder: A systematic review and meta‐analysis

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