Functional gallbladder disease: Operative trends and short-term outcomes

Thiels, Cornelius A.; Hanson, Kristine T.; Chawla, Kashmira S.; Topazian, Mark D.; Paley, Keith H.; Habermann, Elizabeth B.; Bingener, Juliane

doi:10.1016/j.surg.2016.03.005

Cited by 16 publications

(8 citation statements)

References 19 publications

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“…In China, with gallstones >3.6 cm, atrophic cholecystitis, gallstones filled gallbladder (up to 823 stones, and mucosal tissue with no histopathological changes of atypical hyperplasia), yet gallstone preservation is adopted [31].…”

Section: Cholecystolithotripsy For Patients With Symptomatic Chronic mentioning

confidence: 99%

Advances in Gallbladder-Preserving Surgery for Gallbladder Diseases

Gs¹,

Zhao²,

Huang³

et al. 2019

Clin Res Open Access

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Research on gallbladder diseases, whether in basic pathogenesis or clinical treatment, has been continuing and developing. Currently, gallbladderpreserving lithotripsy has attracted considerable attention in the treatment of cholecystolithiasis in China. In recent years, Endoscopic Minimally Invasive Gallbladder-Preserving Surgery (CGPS) has become more and more mature. However, the recurrence rate of gallstones after CGPS has been an urgent question that requires careful investigation. This article reviews the progress in postoperative recurrence of gallbladder diseases treated with gall bladder preservation surgery.

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Section: Cholecystolithotripsy For Patients With Symptomatic Chronic mentioning

confidence: 99%

Advances in Gallbladder-Preserving Surgery for Gallbladder Diseases

Gs¹,

Zhao²,

Huang³

et al. 2019

Clin Res Open Access

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“…Rome II, III and IV criteria are diagnostic guidelines established for functional gastrointestinal disorders that define essential and supportive features of symptoms that codify this disease 6,7 . Biliary dyskinesia is defined as typical biliary pain, normal liver and pancreas biochemistry, normal US and poor gallbladder emptying defined as a gallbladder ejection fraction (GBEF) on cholecystokinin cholescintigraphy 1,8 .…”

Section: Introductionmentioning

confidence: 99%

“…The prevalence of gallbladder dyskinesia ranges from 6% to 25% in patients with biliary pain presentations 14 . When ROME III/IV criteria 6,8,15,16 are used, nearly 0.2% of general population has gallbladder dyskinesia and comprises 2–8% of the indications for adults undergoing cholecystectomy 7,17 . The pathophysiology of this disease is unclear.…”

Section: Introductionmentioning

confidence: 99%

Cholescintigraphy may have a role in selecting patients with biliary dyskinesia for cholecystectomy: a systematic review

Alhayo

Eslick

Cox

2020

ANZ Journal of Surgery

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Background Patients with typical biliary pain, no gallstones on ultrasound and low gallbladder ejection fraction (GBEF) on cholescintigraphy (gallbladder dyskinesia) may be considered for a laparoscopic cholecystectomy. However, some studies have suggested that symptoms alone are an adequate indication for laparoscopic cholecystectomy. The aim was to determine the role of cholescintigraphy in predicting outcomes of cholecystectomy in patients with typical and atypical biliary symptoms and normal biliary ultrasound. Methods Meta‐analysis using Preferred Items for Systematic reviews and Meta‐Analysis (PRISMA) guidelines of published literature using several electronic databases. Results Twenty‐four articles were selected with a total of 1710 patients. The majority (n = 1633, 94.4%) of patients had typical biliary symptoms. A total of 1047 patients with typical symptoms and a reduced GBEF had a cholecystectomy with 852 (81.4%) having complete resolution of symptoms. A total of 148 with typical symptoms and normal GBEF had a cholecystectomy with 103 (69.5%) having complete resolution, which was significantly less than those with a reduced GBEF (odds ratio 1.65, confidence interval 1.08–2.05, P = 0.01). Forty‐five patients with atypical symptoms and a reduced GBEF had a cholecystectomy with 31 (68.9%) having complete resolution of symptoms, which is significantly lower than those with typical symptoms (odds ratio 1.97, confidence interval 0.95–3.90, P = 0.05). Conclusion Cholescintigraphy improved the predication of outcome of cholecystectomy in biliary dyskinesia by 10%. However, the presence of typical symptoms does predict an effective response in 70% of patients. Atypical symptoms predict a poorer response.

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“…The major short term complication is biliary tract injury, which seriously affects the patient's quality of life, and can cause a secondary operation. When it comes to the irreparable biliary stenosis, it could even threaten the patient's life [11,12]. Long term complications of cholecystectomy are easy to be ignored, which mainly included dyspepsia and the increased risk of gastrointestinal cancer [13,14].…”

Section: Introductionmentioning

confidence: 99%

A Case-Control Study on the Relationship Between Cholecystectomy and Cholangiocarcinoma in China

Zhu¹,

Fu²,

Zhang³

et al. 2020

Preprint

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Aims: The present study aimed to explore the correlation between cholecystectomy and cholangiocarcinoma, and to provide preliminary clinical basis for precise cholecystectomy in China.Methods: We conducted a retrospective analysis of 9744 patients with cholangiocarcinoma, colon cancer, pancreatic cancer, femoral fracture, and hepatic hemangioma diagnosed in Xijing hospital from August 2008 to August 2018. They were divided into three groups: case group (1749 cases of cholangiocarcinoma), positive control group (3137 cases of colon cancer and 1950 cases of pancreatic cancer), negative control group (1794 cases of femoral fracture and 1114 cases of hepatic hemangioma). We collected the general information (gender, age), past medical history, cholecystectomy history from the patients, and these data were analyzed by chi-square test and logistic regression analysis. Results: The cholecystectomy rate of the case group was significantly higher than that of the positive control group and the negative control group by chi-square test (p<0.025). The cholecystectomy rate and the history of cholecystolithiasis were analyzed by logistic multivariate regression analysis. The OR values of cholecystectomy rate were 1.553 (95%CI: 1.311-1.840) and 3.181 (95%CI: 2.561-3.951), respectively, and the difference was statistically significant (p<0.000). The OR values of the history of cholecystolithiasis were 2.460 (95%CI: 2.093-2.890) and 5.426 (95%CI: 4.325-6.809), respectively, and the difference was statistically significant (p<0.000). In case group, the difference between cholecystectomy and cholecystolithiasis was statistically significant (p<0.000) by chi-square test. Conclusions: In conclusion, cholecystectomy is one of the risk factors of cholangiocarcinoma and the patients who undergo cholecystectomy have a higher risk of cholangiocarcinoma than the control groups. Cholecystectomy should be conducted with caution and the precise surgical treatment of gallbladder diseases is advocated.

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Functional gallbladder disease: Operative trends and short-term outcomes

Cited by 16 publications

References 19 publications

Advances in Gallbladder-Preserving Surgery for Gallbladder Diseases

Advances in Gallbladder-Preserving Surgery for Gallbladder Diseases

Cholescintigraphy may have a role in selecting patients with biliary dyskinesia for cholecystectomy: a systematic review

A Case-Control Study on the Relationship Between Cholecystectomy and Cholangiocarcinoma in China

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