Functional Fractionation of the Cingulo-opercular Network: Alerting Insula and Updating Cingulate

Han, Suk Won; Eaton, Hana P.; Marois, René

doi:10.1093/cercor/bhy130

Cited by 64 publications

(43 citation statements)

References 66 publications

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“…The salience of the first trial might account for the rapid activation change in the cinguloopercular network, providing an orienting or updating signal to the control system (Menon and Uddin, 2010;Han et al, 2019). The first trial is salient because it is the only trial that alerts participants to the novel control demands.…”

Section: Discussionmentioning

confidence: 99%

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Fronto-parietal, cingulo-opercular and striatal contributions to learning and implementing control policies

Bhandari

Badrre

2020

Preprint

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Efficient task performance requires co-ordination of internal cognitive processes by implementing control policies adapted to the dynamic structure of task demands. The cognitive and neural basis of control policy implementation remains poorly characterized, in part because it is typically confounded with implementing new stimulus-response rules. To disambiguate these processes, we asked participants to perform multiple novel variants of a working memory control task. Each variant had a unique, novel sequential trial structure, but all shared common stimulusresponse rules, enabling us to test control policy implementation separate from rule learning. Behaviorally, we found evidence for two adaptive processes tied to control policy implementation. One process was reflected in slower responses on the first trial with a novel sequential trial structure, followed by rapid speeding on subsequent trials. A second process was reflected in the diminishing size of the first trial cost as participants accommodated different variants of the task over many blocks. Using fMRI, we observed that the striatum and a cinguloopercular cortical network increased activity to the first trial, tracking the fast adjustment. This pattern of activity dissociated these regions from a fronto-parietal network including dorsolateral PFC, inferior frontal junction, inferior parietal sulcus, and rostrolateral PFC, which showed a slower decline in activity across trials, mirroring findings in rule implementation studies, but in the absence of rule implementation demands. Our results reveal two adaptive processes underlying the implementation of efficient, generalizable control policies, and suggest a broader account of the role of a cortico-striatal network in control policy implementation. Implementing Control Policies 3 Significance statementRapid adaptation to novel tasks is a hallmark of human behavior. Understanding how human brains achieve this is of critical importance in neuroscience. Here we broaden the scope of this problem, going beyond task rules to more broadly consider the cognitive control demands produced by novel task dynamics. We propose that humans rely on two adaptive processes to rapidly implement efficient, generalizable control policies as task dynamics change, even when task rules remain unchanged. One process unfolds rapidly and underlies efficient adaptation. A second process unfolds slowly with experience across task conditions and underlies generalization of control policies. Using fMRI, we identify cingulo-opercular cortex, fronto-parietal cortex and striatum as dissociable components of a cortico-striatal network that contribute to control implementation.

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Section: Discussionmentioning

confidence: 99%

“…Indeed, transient striatal activity has also been observed with salient oddball events (Han et al, 2019), and the caudate is considered a subcortical node of the salience network (Peters et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Fronto-parietal, cingulo-opercular and striatal contributions to learning and implementing control policies

Bhandari

Badrre

2020

Preprint

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“…Within the salience network, the aINS is suggested to activate the dACC when salient stimuli are detected ( Downar et al, 2000 ). Indeed, the dACC is activated transiently after changing salient stimuli and the presentation of goal-directed salient stimuli ( Han et al, 2018 ). As the present findings show a poor connection between claustrum and the aINS of mouse, it is possible an alternative brain region is structurally connected to both aINS and ACC/dACC that allows for aINS-dACC co-activation in response to salient stimuli.…”

Section: Discussionmentioning

confidence: 99%

Structural Connectivity of the Anterior Cingulate Cortex, Claustrum, and the Anterior Insula of the Mouse

Qadir

Krimmel

et al. 2018

Front. Neuroanat.

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The claustrum is a narrow subcortical brain structure that resides between the striatum and insular cortex. The function of the claustrum is not fully described, and while our previous work supports a role for the claustrum in top-down cognitive control of action, other evidence suggests the claustrum may be involved in detecting salient changes in the external environment. The anterior cingulate cortex (ACC) and the anterior insular (aINS) are the two major participants in the salience network of human brain regions that activate in response to salient stimuli. While bidirectional connections between the ACC and the claustrum exist from mouse to non-human primate, the aINS connectivity with claustrum remains unclear, particularly in mouse. Here, we explored structural connections of the aINS with the claustrum and ACC through adeno-associated virus neuronal tract tracer injections into the ACC and aINS of the mouse. We detected sparse projections from the claustrum to the aINS and diffuse projections from the aINS to the borders of the claustrum were observed in some cases. In contrast, the insular cortex and endopiriform nucleus surrounding the claustrum had rich interconnectivity with aINS. Additionally, we observed a modest interconnectivity between ACC and the aINS. These data support the idea that claustrum neuron responses to salient stimuli may be driven by the ACC rather than the aINS.

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“…While this may be due to variability in response to the appetitive touch manipulation used in the current design, the identification of a clear appetitive brush pattern component in the vmPFC indicated that this is unlikely. Instead, this absence likely reflects the role of these regions in guiding both interoceptive and stimulus-guided attention (Han et al, 2019;Wang et al, 2019). Pain may be the more salient tactile signal for indicating the well-being of an organism, and thus given greater priority of resources.…”

Section: Mixed Cortical Representation Of Tactile Informationmentioning

confidence: 99%

Decoding representations of discriminatory and hedonic information during appetitive and aversive touch

Kryklywy¹,

Ehlers

Beukers³

et al. 2020

Preprint

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In the somatosensory system, hedonic information is coded by mechanoreceptors at the point of contact. Pleasure and pain signals travel along peripheral nerve pathways distinct from those for discriminative touch. Yet it remains unknown whether the central nervous system represents tactile hedonic information in sensory cortices as another dimension of exteroceptive information, similar to discriminative touch signals, or if tactile hedonic information is instantiated in regions mediating internal interoceptive states. Employing representational similarity analysis with a new approach of pattern component modeling, we decomposed multivoxel patterns to demonstrate that signals of painful but not pleasurable touch are represented in primary somatosensory cortices. By contrast, all hedonic touch representations were identified in regions associated with affect and interoception. This suggests that touch should be divided into external-exteroceptive and internal-interoceptive dimensions, with hedonic touch represented as an internal state, even though evoked by external stimulation.

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Functional Fractionation of the Cingulo-opercular Network: Alerting Insula and Updating Cingulate

Cited by 64 publications

References 66 publications

Fronto-parietal, cingulo-opercular and striatal contributions to learning and implementing control policies

Fronto-parietal, cingulo-opercular and striatal contributions to learning and implementing control policies

Structural Connectivity of the Anterior Cingulate Cortex, Claustrum, and the Anterior Insula of the Mouse

Decoding representations of discriminatory and hedonic information during appetitive and aversive touch

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