Functional Foods for Health: The Interrelated Antioxidant and Anti-Inflammatory Role of Fruits, Vegetables, Herbs, Spices and Cocoa in Humans

Serafini, Mauro; Peluso, Ilaria

doi:10.2174/1381612823666161123094235

Cited by 173 publications

(111 citation statements)

References 116 publications

(140 reference statements)

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“…week. Our ndings are consistent with the known antioxidant properties of some foods (47)(48)(49). It is to mention that in our study fruits consumption had a negative correlation with oxidative stress in all the 290 women, however, in the distinct subgroups of 100 OC-users and 190 non-OC-users such negative correlation did not reach statistical signi cance, thus, fruits effects will require further research (48).…”

Section: Oxidative Stresssupporting

confidence: 87%

Increase of Oxidative Stress is Positively Associated with High-Sensitivity C-Reactive Protein in Women Using Combined Oral Contraceptives: An Observational Study

Cauci

Francescato

Colannino

et al. 2020

Preprint

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Background Information concerning oxidative stress and low-grade inflammation in oral contraception users is scarce. We investigated relationships of oxidative stress and high-sensitivity C-reactive protein (hsCRP) in women by oral combined contraceptive (OC) use. Methods Caucasian Italian healthy non-obese women (n = 290; 100 OC-users; 190 non-OC-users; mean age 23.2 ± 4.7 years) were analyzed. Blood hydroperoxides, as oxidative stress biomarkers, were assessed by Free Oxygen Radical Test (FORT), and serum hsCRP was determined by routine methods. Results Oxidative stress levels were elevated (≥ 400 FORT Units) in 77.0% and 15.8% of OC-users and non-OC-users, respectively (odds ratio (OR) = 209, 95%CI = 60.9-715.4, p < 0.001); hsCRP levels ≥ 2.0 mg/L were found in 41.0% and 9.5% of OC-users and non-users, respectively (OR = 6.6, 95%CI 3.5–12.4, p < 0.001). Continuous hydroperoxides values in OC-users were 1.7-fold higher compared to non-users (median 472 versus 270 FORT Units, p < 0.001); OC-users had 3.7-fold higher hsCRP values compared to non-OC-users (median 1.31 versus 0.35 mg/L, p < 0.001). Hydroperoxides were strongly positively correlated to hsCRP in all women (rs=0.622, p < 0.001), in OC-users (rs=0.442, p < 0.001), and in non-OC-users (rs=0.426, p < 0.001). Women with hydroperoxides ≥ 400 FORT Units were 8 times as likely to have hsCRP ≥ 2 mg/L. In non-OC-users only, hydroperoxides values were positively correlated with weight and body mass index, but negatively correlated with red meat, fish and chocolate consumption. Conclusions Our cross-sectional observational study is the first finding a strong positive correlation of serum hydroperoxides with hsCRP, a marker of inflammation. Further research is needed to elucidate the potential role of these two biomarkers in OC-use side-effects, like thromboembolism.

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Section: Oxidative Stresssupporting

confidence: 87%

Increase of Oxidative Stress is Positively Associated with High-Sensitivity C-Reactive Protein in Women Using Combined Oral Contraceptives: An Observational Study

Cauci

Francescato

Colannino

et al. 2020

Preprint

View full text Add to dashboard Cite

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“…In clinical studies, assessing antioxidative and anti‐inflammatory properties of fruit juices, pomegranate juice (100 cc/day for 1 year) (Hosseini, Saedisomeolia, Wood, Yaseri, & Tavasoli, ), and concentrated pomegranate juice (50 g/day for 4 weeks) (Shishehbor et al., ) decreased interleukin‐6 (IL‐6) level (Hosseini et al., ; Shema‐Didi et al., ; Shishehbor et al., ) or decreased lipid and protein oxidation markers levels (Hosseini et al., ; Shema‐Didi et al., ) in patients with type 2 diabetes (Shishehbor et al., ), patients on hemodialysis (Shema‐Didi et al., , ), and overweight or obese adults (Hosseini et al., ; Serafini & Peluso, ). Cranberry juice (700 mL/day for 60 days in a parallel design) significantly reduced lipid and protein oxidation markers levels and increased the anti‐inflammatory adiponectin level in patients with metabolic syndrome (Simão et al., ).…”

Section: Functional Food Products For Older Individualsmentioning

confidence: 99%

Recent progress in the use of functional foods for older adults: A narrative review

Jędrusek‐Golińska

Górecka

Buchowski

et al. 2020

Comp Rev Food Sci Food Safe

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The number and proportion of older adults are increasing globally, and it is predicted that in 2020, there will be 723 million people worldwide aged 66 and older. In recent decades, numerous studies showed that healthy eating is positively associated with better nutritional status and quality of life, and the decreased incidence of noncommunicable diseases. As older adults become health conscious, the demand for foods and beverages rich in nutrients and bioactive compounds has increased. The increased demand for healthy food stimulated a recent rapid increase in designing, producing, and marketing functional foods to prevent or correct nutrient deficiencies and to improve the nutritional status of older adults. These functional products contain and/or are enriched with dietary fiber; omega‐3 polyunsaturated fatty acids; phytoestrogens; polyphenols; carotenoids such as alpha‐ and beta‐carotene; lutein and zeaxanthin; pre‐, pro‐, and synbiotics; and plant sterols and stanols. A limited number of publications have thoroughly addressed the effect of functional foods on the nutritional status of older adults. The goal of this review was to review existing recent research on the role of functional foods in healthy and active aging.

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“…Throughout history, natural substances were widely used to treat various diseases [1]. Food of plant origin is associated with health-profitable benefits [2] related to bioactive compounds [3]. Phytochemicals are bioactive non-nutrients found in fruit, vegetable, or other plant sources exerting antioxidant, antiinflammatory, and other beneficial effects [4,5].…”

Section: Introductionmentioning

confidence: 99%

Fluctuations of Histone Chemical Modifications in Breast, Prostate, and Colorectal Cancer: An Implication of Phytochemicals as Defenders of Chromatin Equilibrium

et al. 2019

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Natural substances of plant origin exert health beneficiary efficacy due to the content of various phytochemicals. Significant anticancer abilities of natural compounds are mediated via various processes such as regulation of a cell’s epigenome. The potential antineoplastic activity of plant natural substances mediated by their action on posttranslational histone modifications (PHMs) is currently a highly evaluated area of cancer research. PHMs play an important role in maintaining chromatin structure and regulating gene expression. Aberrations in PHMs are directly linked to the process of carcinogenesis in cancer such as breast (BC), prostate (PC), and colorectal (CRC) cancer, common malignant diseases in terms of incidence and mortality among both men and women. This review summarizes the effects of plant phytochemicals (isolated or mixtures) on cancer-associated PHMs (mainly modulation of acetylation and methylation) resulting in alterations of chromatin structure that are related to the regulation of transcription activity of specific oncogenes, which are crucial in the development of BC, PC, and CRC. Significant effectiveness of natural compounds in the modulation of aberrant PHMs were confirmed by a number of in vitro or in vivo studies in preclinical cancer research. However, evidence concerning PHMs-modulating abilities of plant-based natural substances in clinical trials is insufficient.

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Functional Foods for Health: The Interrelated Antioxidant and Anti-Inflammatory Role of Fruits, Vegetables, Herbs, Spices and Cocoa in Humans

Cited by 173 publications

References 116 publications

Increase of Oxidative Stress is Positively Associated with High-Sensitivity C-Reactive Protein in Women Using Combined Oral Contraceptives: An Observational Study

Increase of Oxidative Stress is Positively Associated with High-Sensitivity C-Reactive Protein in Women Using Combined Oral Contraceptives: An Observational Study

Recent progress in the use of functional foods for older adults: A narrative review

Fluctuations of Histone Chemical Modifications in Breast, Prostate, and Colorectal Cancer: An Implication of Phytochemicals as Defenders of Chromatin Equilibrium

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