Functional foods and physical activities in health promotion of aging people

Ferrari, Carlos Kusano Bucalen

doi:10.1016/j.maturitas.2007.09.011

Cited by 61 publications

(33 citation statements)

References 109 publications

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“…Further, for many elderly patients the presence of multiple pathologies is a common feature, especially overweight/obesity, hypertension, atherosclerosis, type 2 diabetes, chronic kidney disease, neurodegenerative disorders and the metabolic syndrome (Jones et al 2002;Ferrari 2007;Qureshi and Parvez 2007;Morais et al 2008;Tsirpanlis 2008;Thorin and Thorin-Trescases 2009). These diseases usually shorten the life span (Fontaine et al 2003;Qureshi and Parvez 2007).…”

Section: Antioxidant Capacity and Healthy Aging: Does Exercise Matter?mentioning

confidence: 99%

Exercise modulation of total antioxidant capacity (TAC): towards a molecular signature of healthy aging

Ferrari

2011

Frontiers in Life Science

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The objective of this article was to review the biochemical basis of the total antioxidant capacity (TAC) test and its applications to exercise science and promotion of healthy aging. Measurement of TAC allows evaluation of the antioxidant content of muscle, heart and other exercise-target organs. Acute non-regular physical exercise and body exposition to higher altitude have been associated with a considerable decrease of blood TAC. However, regular practice of physical activity and exercise is associated with improved antioxidant response increasing TAC levels. TAC methodologies did not address lipophylic antioxidants and have some other limitations. However, TAC is useful as a complementary test for the evaluation of antiperoxidation assays and blood, erythrocyte and cytosolic antioxidant enzyme assays (glutathion reductase, glutathion peroxidase, superoxide dismutase and catalase). Exercise induces both molecular antioxidant and hormetic responses which have been suggested to be linked with a healthy aging.

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Section: Antioxidant Capacity and Healthy Aging: Does Exercise Matter?mentioning

confidence: 99%

Exercise modulation of total antioxidant capacity (TAC): towards a molecular signature of healthy aging

Ferrari

2011

Frontiers in Life Science

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“…Mounting evidence suggests that lifestyle factors, especially the diet, may account for the development of chronic diseases, such as cardiovascular disease, diabetes and neurodegenerative disease (Ferrari, 2007). Nowadays, while major dietary intervention has been applied to prevent such diseases as diabetes and heart disease, the potential impact of diet on aging process-associated neurodegeneration has been neglected.…”

Section: Introductionmentioning

confidence: 99%

Marine collagen peptide isolated from Chum Salmon (Oncorhynchus keta) skin facilitates learning and memory in aged C57BL/6J mice

et al. 2010

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“…Chronic triggering of TLR4 pathway induces both insulin resistance and amyloid beta deposition [103]. It has been suggested that TLR4 action is mediated by NFkB signaling pathway [104]. These complex prodiabetic and antidiabetic molecular mechanisms are represented in Figure 1.…”

Section: Molecular Pathways Of Diabetes Mellitus Pathogenesismentioning

confidence: 99%

Antioxidant defenses in diabetes mellitus: a clinical and molecular approach

Ferrari¹

2017

Integr Obesity Diabetes

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Oxidative and nitrosative stress reactions are implicated in cell and organ damage due to diabetes mellitus. In both type 1 and type 2 DM there is a massive oxidative and nitrosative stresses which have been associated with intensive changes on both antioxidant enzyme systems (SOD, CAT, GPx, GSH) and total antioxidant capacity (TAC) causing peroxidative damage to lipids, proteins, nucleic acids and carbohydrates which can be used as DM biomarkers. Molecular pathophysiology of diabetes mellitus envolves induction of the the NFkB and p38-MAPK cell signaling pathways by Rac, TNF-α, TLR4, decrease of antioxidant defenses, and direct mitochondrial damage. Knowledge of molecular pathways is essential for research of newer preventive and therapeutic approaches in diabetes mellitus complications (atherosclerosis, myocardial damage, endothelial dysfunction, and renal failure).urine, feces, tissue sample), vegetable or fruit extract or even foods or pharmaceuticals [14][15][16].This article review and update the clinical, cellular, and molecular knowledge of free radicals and antioxidant defenses in diabetes mellitus. Ethiopathogenesis of diabetes mellitus I and IIDiabetes mellitus has been conceptualized as a group of metabolic disorders characterized by hyperglicemia as a result of insulin secretion failure and/or lacking of insulin action on target cells. The chronic diabetic hyperglicemic state has been related to long-term organ damage especially to the heart, endothelium and blood vessels, nerves, kidney, and eyes [17][18][19].

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Functional foods and physical activities in health promotion of aging people

Cited by 61 publications

References 109 publications

Exercise modulation of total antioxidant capacity (TAC): towards a molecular signature of healthy aging

Exercise modulation of total antioxidant capacity (TAC): towards a molecular signature of healthy aging

Marine collagen peptide isolated from Chum Salmon (Oncorhynchus keta) skin facilitates learning and memory in aged C57BL/6J mice

Antioxidant defenses in diabetes mellitus: a clinical and molecular approach

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