Functional fluorescent nonporous silica nanoparticles as carriers for Pt(IV) anticancer prodrugs

Ravera, Mauro; Perin, Elena; Gabano, Elisabetta; Zanellato, Ilaria; Panzarasa, Guido; Sparnacci, Katia; Laus, Michele; Osella, Domenico

doi:10.1016/j.jinorgbio.2015.08.001

Cited by 22 publications

(19 citation statements)

References 65 publications

(83 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By contrast, the incorporation of the tridentate ligand 3 led to a chitosan-conjugate (C123) presenting an IC 50 value (13.5 µM) similar to that found for the free Pt(IV) complex. These data are in clear contrast with the nanomolar IC 50 values obtained for Pt(IV)-silica nanoparticles, carrying the same Pt(IV) prodrug [35,36]. Hence, it seems that the Pt(IV)-chitosan conjugation do not result in an improvement of the cytotoxic activity, namely when compared with cisplatin.…”

Section: Antiproliferative Activity and Cellularmentioning

confidence: 63%

“…Prodrug 2 was chosen based on previous studies where it was loaded on amino-functionalized nonporous silica nanoparticles resulting in conjugates with high cellular uptake and good antitumor activity [35,36]. Moreover, the presence of only one axial carboxylate functionality prevents the formation of cross-links between amino groups of different C1 molecules decreasing the size of the nanoparticles [36].…”

Section: Synthesis and Characterization Of The Conjugatesmentioning

confidence: 99%

“…Moreover, the presence of only one axial carboxylate functionality prevents the formation of cross-links between amino groups of different C1 molecules decreasing the size of the nanoparticles [36].…”

Section: Synthesis and Characterization Of The Conjugatesmentioning

confidence: 99%

“…In fact, spherical nonporous silica nanoparticles (NSNP) with an external shell containing primary amino groups were used as delivery systems for different Pt(IV) complex. The conjugates Pt(IV)-NSNP exhibited much better antiproliferative activity on the Pt-sensitive ovarian A2780 cell line than parent cisplatin and free complexes, due to their more efficient cellular uptake (in all cases AR > 30) [35,36]. On the contrary, phenanthriplatin (i.e., (SP-4-3)-diamminechlorido(phenanthridine)platinum(II) nitrate) loaded on negatively charged dextran sulfate, a polysaccharide not very different from chitosan, resulted in slightly less active than free phenanthriplatin.…”

Section: Antiproliferative Activity and Cellularmentioning

confidence: 99%

See 3 more Smart Citations

Pt(IV)/Re(I) Chitosan Conjugates as a Flexible Platform for the Transport of Therapeutic and/or Diagnostic Anticancer Agents

et al. 2017

Self Cite

View full text Add to dashboard Cite

New chitosan derivatives modified with (3-carboxypropyl)trimethylammonium chloride (1) and coupled with (OC-6-44)-diammine(4-carboxypropanoato)dichloridoethanolatoplatinum(IV) (2), were synthesized and their preliminary biological evaluation carried out in human tumor cells. Some of these derivatives were also loaded with a chelating ligand (3) that was derived from bis(quinolin-2-ylmethyl)amine to obtain chitosan-based nanoparticles for an EPR-mediated delivery of Pt(IV) prodrugs and Re(I) tricarbonyl complexes (4), to explore a multimodal theranostic approach to cancer. The cytotoxicity of the different chitosan conjugates (C12, C123, and C1234), carrying different combinations of the Pt(IV) complex, the chelator and the Re(I) complex, was evaluated in the A2780 human ovarian cancer cell line using the MTT assay. The Pt(IV)-containing nanosystems showed low to moderate cytotoxic activity (IC 50 values in the range 13.5-33.7 µM) and was comparable to that found for the free Pt(IV) complex (IC 50 = 13.7 µM). Therefore, the Pt(IV)-chitosan conjugation did not enhance the cytotoxic activity of the Pt(IV) prodrug, which certainly reflects the inefficient cellular uptake of the nanoconjugates. Nevertheless, a clearer view of their potential for the delivery of anticancer agents requires further in vivo tests because the EPR effect increases extravasation and retention within the tumor tissue, not necessarily within the tumor cells.

show abstract

Section: Antiproliferative Activity and Cellularmentioning

confidence: 63%

Section: Synthesis and Characterization Of The Conjugatesmentioning

confidence: 99%

Section: Synthesis and Characterization Of The Conjugatesmentioning

confidence: 99%

Section: Antiproliferative Activity and Cellularmentioning

confidence: 99%

See 2 more Smart Citations

Pt(IV)/Re(I) Chitosan Conjugates as a Flexible Platform for the Transport of Therapeutic and/or Diagnostic Anticancer Agents

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…Silica nanospheres were synthesized using a previously reported Stöber method 25,26 The final concentration of the suspension, determined gravimetrically, was 134 mg mL -1 .…”

Section: Synthesis Of Silica Nanoparticlesmentioning

confidence: 99%

Crafting positive/negative patterns and nanopillars of polymer brushes by photocatalytic lithography

Panzarasa

Soliveri

Ardizzone

2016

Colloids and Surfaces A: Physicochemical and Engineering Aspect

Self Cite

View full text Add to dashboard Cite

HIGHLIGHTSPhotocatalytic lithography is demonstrated as an efficient and versatile patterning strategy.Both positive and negative patterns of polymer brushes are obtained using direct photocatalytic lithography.Nanosphere lithography coupled to remote photocatalysis allows to achieve polymer pillars patterns with nanoscale size. KEYWORDSPolymer brushes, Titanium dioxide, Photocatalytic lithography, Patterning, Nanosphere lithography, Nanopillars, SI-ATRP GRAPHICAL ABSTRACT ABSTRACT We demonstrate how micro-and nanostructures of polymer brushes can be prepared using photocatalytic lithography as a convenient and versatile approach. Both positive and negative micro-patterns of polymer brushes are obtained by patterning self-assembled monolayers through direct photocatalytic lithography. Such approach mimics conventional photolithography but is free from the disadvantages associated to the use of polymeric resists. Moreover, for the first time, the ability to generate nanometer-sized pillars of polymer brushes using remote photocatalysis coupled with nanosphere lithography is demonstrated. Our results confirm the great potentialities of photocatalytic lithography for efficient patterning of polymer brushes.

show abstract

Current Trends in the Preparation of Nanoparticles for Drug Delivery

Bhat

Khanam

Bhat

2017

Engineering Applications of Nanotechnology

View full text Add to dashboard Cite

Functional fluorescent nonporous silica nanoparticles as carriers for Pt(IV) anticancer prodrugs

Cited by 22 publications

References 65 publications

Pt(IV)/Re(I) Chitosan Conjugates as a Flexible Platform for the Transport of Therapeutic and/or Diagnostic Anticancer Agents

Pt(IV)/Re(I) Chitosan Conjugates as a Flexible Platform for the Transport of Therapeutic and/or Diagnostic Anticancer Agents

Crafting positive/negative patterns and nanopillars of polymer brushes by photocatalytic lithography

Current Trends in the Preparation of Nanoparticles for Drug Delivery

Contact Info

Product

Resources

About