Functional expression of receptor activator of nuclear factor κB in Hodgkin disease cell lines

Notch is an essential upstream regulator of NF-κB and is relevant for survival of Hodgkin and Reed–Sternberg cells

“…RANKL is known to activate NF-kB and induces mRNA expression of cytokines and chemokines in HRS cells. 30 These data reveal as yet unknown cross talk between the NF-kB and Notch pathways in HRS cells, and provide evidence that alternative NF-kB p52/RelB is downstream of Notch.…”

Aberrant NF-κB2/p52 expression in Hodgkin/Reed–Sternberg cells and CD30-transformed rat fibroblasts

“…These observations suggest that CD30 is a likely candidate that participates in the constitutive NF-kB activation and development of the oncogenic phenotype found in EBV-negative H-RS cells. Since two other TNF receptor family proteins CD40 and RANK are also reported to be expressed in H-RS cells (Carbone et al, 1995;Annunziata et al, 2000;Fiumara et al, 2001;Ku¨ppers et al, 2003) and implicated in the processing of p100 (Coope et al, 2002;Novack et al, 2003), it would be intriguing to examine possible contribution of these molecules to the NF-kB activity in H-RS cells. Several lines of evidence suggest that CD30 supports survival of H-RS cells in multiple ways.…”

Clinical implications of the tumor necrosis factor family in benign and malignant hematologic disorders

“…Fiumara et al reported that both primary and cultured H/RS cells of Hodgkin disease expressed RANK and RANKL. 70 In Hodgkin-derived cell lines, RANKL activated survival pathways (NF-B and MAP kinase) in a time-dependent manner and induced the expression and secretion of several cytokines and chemokines in an autocrine manner. 70 Thus the RANK/RANKL axis may be involved in attracting the heavy cellular infiltrate in Hodgkin's disease lesions.…”