Functional Evolution of Cyclin-Dependent Kinases

Doonan, John H.; Kitsios, Georgios D

doi:10.1007/s12033-008-9126-8

Cited by 64 publications

(60 citation statements)

References 182 publications

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“…[47][48][49][50] Although the prototypical CDK1/A has a primary function as a central cell cycle regulator, the other groups have been implicated in additional diverse cellular processes like regulation of transcription, translation and mRNA processing. 51,52 Higher eukaryotes possess a number of cdc2/CDC28-related genes, 53 now known as CDKs, with the different classes designated by numbers (animals) or letters and numbers (plants). Thus, in Arabidopsis, seven different classes of CDKs named CDKA through CDKF have been described based on their cyclin binding motif.…”

Section: ©2 0 1 1 L a N D E S B I O S C I E N C E D O N O T D I S Tmentioning

confidence: 99%

Cyclin dependent protein kinases and stress responses in plants

Kitsios

Doonan

2011

Plant Signaling & Behavior

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Section: ©2 0 1 1 L a N D E S B I O S C I E N C E D O N O T D I S Tmentioning

confidence: 99%

Cyclin dependent protein kinases and stress responses in plants

Kitsios

Doonan

2011

Plant Signaling & Behavior

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“…Although CDKs were originally identified as key regulators of cell cycle transition (CDK1, 2, 4, and 6; Rane et al, 1999;Moore et al, 2003;Kozar et al, 2004), members in this family were also found to be involved in other cellular processes, such as activation of other CDKs (CDK7; Kaldis, 1999) and regulation of gene transcription by phosphorylating RNA polymerase II (CDK7, 8, and 9;Pinhero et al, 2004). Recent studies both in animal and plant cells suggest that a number of CDKs may function in RNA splicing regulation (Doonan and Kitsios, 2009). Human CDK11 p110 interacts in vivo with two splicing factors, RNPS1 and 9G8, and promotes the splicing of b-globin pre-mRNA in vitro (Hu et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

CYCLIN-DEPENDENT KINASE G1 Is Associated with the Spliceosome to RegulateCALLOSE SYNTHASE5Splicing and Pollen Wall Formation inArabidopsis

et al. 2013

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Arabidopsis thaliana CYCLIN-DEPEDENT KINASE G1 (CDKG1) belongs to the family of cyclin-dependent protein kinases that were originally characterized as cell cycle regulators in eukaryotes. Here, we report that CDKG1 regulates pre-mRNA splicing of CALLOSE SYNTHASE5 (CalS5) and, therefore, pollen wall formation. The knockout mutant cdkg1 exhibits reduced male fertility with impaired callose synthesis and abnormal pollen wall formation. The sixth intron in CalS5 pre-mRNA, a rare type of intron with a GC 59 splice site, is abnormally spliced in cdkg1. RNA immunoprecipitation analysis suggests that CDKG1 is associated with this intron. CDKG1 contains N-terminal Ser/Arg (RS) motifs and interacts with splicing factor Arginine/SerineRich Zinc Knuckle-Containing Protein33 (RSZ33) through its RS region to regulate proper splicing. CDKG1 and RS-containing Zinc Finger Protein22 (SRZ22), a splicing factor interacting with RSZ33 and U1 small nuclear ribonucleoprotein particle (snRNP) component U1-70k, colocalize in nuclear speckles and reside in the same complex. We propose that CDKG1 is recruited to U1 snRNP through RSZ33 to facilitate the splicing of the sixth intron of CalS5.

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“…44,45 In plants and animals, a number of CDKs participate in the regulation of GSL RNA splicing. 46 In Arabidopsis thaliana, CDKG1 regulates the pre-mRNA splicing of AtGSL2. A knockout mutant of CDKG1 exhibited a low panicle seed setting rate, and further work indicated that the sixth intron of the CDKG1 pre-mRNA was altered in the cdkg1 mutant.…”

Section: Callose Biosynthesis During Male Reproductive Development Inmentioning

confidence: 99%

Callose synthesis during reproductive development in monocotyledonous and dicotyledonous plants

Xiao

Han

2015

Plant Signaling & Behavior

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Callose, a linear b-1,3-glucan molecule, plays important roles in a variety of processes in angiosperms, including development and the response to biotic and abiotic stress. Despite the importance of callose deposition, our understanding of the roles of callose in rice reproductive development and the regulation of callose biosynthesis is limited. GLUCAN SYNTHASE-LIKE genes encode callose synthases (GSLs), which function in the production of callose at diverse sites in plants. Studies have shown that callose participated in plant reproductive development, and that the timely deposition and degradation of callose were essential for normal male gametophyte development. In this mini-review, we described conserved sequences found in GSL family proteins from monocotyledonous (Oryza sativa and Zea mays) and dicotyledonous (Arabidopsis thaliana and Glycine max) plants. We also describe the latest findings on callose biosynthesis and deposition during reproductive development and discuss future challenges in unraveling the mechanism of callose synthesis and deposition in higher plants.

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Functional Evolution of Cyclin-Dependent Kinases

Cited by 64 publications

References 182 publications

Cyclin dependent protein kinases and stress responses in plants

Cyclin dependent protein kinases and stress responses in plants

CYCLIN-DEPENDENT KINASE G1 Is Associated with the Spliceosome to RegulateCALLOSE SYNTHASE5Splicing and Pollen Wall Formation inArabidopsis

Callose synthesis during reproductive development in monocotyledonous and dicotyledonous plants

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