Functional Effects of Imipramine on the Rabbit Urinary Bladder: an in-vitro Study

Grover, Rakesh; Wein, Alan J.; Ruggieri, Michael R.; Levin, Robert M.

doi:10.1159/000138458

Cited by 2 publications

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References 15 publications

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“…The various modes of action attributed to imipramine are muscarinic receptor antagonism [13], inhibition of noradrenaline uptake into nerve terminals [14], direct smooth muscle inhibition [13], calcium antagonism [15] and H1 histamine receptor blockade [16]. Grover et al [17] showed that imipramine causes a dose‐dependent inhibition of bladder pressure increase during the plateau phase of bladder filling. Stimulation of the β‐receptors of the bladder dome by peripheral blockade of noradrenaline uptake was proposed to account for the decrease in bladder contractility after imipramine therapy [1].…”

Section: Discussionmentioning

confidence: 99%

The role of imipramine therapy in bladder exstrophy after bladder neck reconstruction

et al. 2002

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Objective To assess the role of imipramine therapy after bladder neck reconstruction in patients with bladder exstrophy. Patients and methods Seventeen children with bladder exstrophy who achieved partial continence after bladder neck reconstruction received imipramine (1.5-2 mg/kg body weight) for a mean duration of 9.5 months. Assessment before and after therapy included an objective classification of the continence status and artificial slow-fill cystometry. Results Eleven of the 17 patients had a good clinical response to imipramine, with an increase in the continent period to >2 h, and in nocturnal continence. The urodynamic findings showed a significant improvement in the capacity, end-fill pressure, uninhibited contractions and '20 below' capacity.Only minor side-effects of the drug were reported. Conclusion Imipramine has a role in patients who achieve partial continence after reconstruction, and who have a moderately small capacity bladder with poor compliance and uninhibited contractions.

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Section: Discussionmentioning

confidence: 99%

The role of imipramine therapy in bladder exstrophy after bladder neck reconstruction

et al. 2002

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In Vitro Intravesical Instillation of Anticholinergic, Antispasmodic and Calcium Blocking Agents (Rabbit Whole Bladder Model)

et al. 1989

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The systemic side effects accompanying oral pharmacotherapy of neurogenic bladder dysfunction present significant drawbacks to this type of therapy. In these studies we investigated the effect of intravesical administration of anticholinergic, antispasmodic and calcium blocking agents on pressure response mediated by field stimulation and bethanechol. We used the rabbit in vitro whole bladder model for these experiments. The bladder from a mature male NZW rabbit was mounted in an organ bath as a whole bladder preparation. After control field stimulation and bethanechol stimulation, 20 ml. of saline containing the specific drug being evaluated was instilled into the bladder. At 30 minute intervals, the responses to field stimulation and bethanechol were determined. Two hours after instillation of 100 microM of each specific drug, the inhibition of the contractile response to bethanechol and field stimulation (as % inhibition) was as follows: oxybutynin (95%/64%), verapamil (85%/81%), atropine (68%/31%), diltiazem (47%/39%), and imipramine (44%/47%). Atropine and oxybutynin suppressed the contractile response of the bladder to bethanechol to a much greater extent than that to field stimulation, while verapamil, diltiazem and imipramine suppressed the contractile response to bethanechol and field stimulation to approximately the same extent. Two hours after drug instillation, the intravesical solution was washed out and replaced with saline, but the recovery of the bladder contraction was slow and incomplete. The results of this study suggest that the use of self-intravesical instillation to suppress bladder contractility should be a good therapeutic approach for patients with neurogenic bladder, especially those who are already managed by intermittent catheterization.

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Functional Effects of Imipramine on the Rabbit Urinary Bladder: an in-vitro Study

Cited by 2 publications

References 15 publications

The role of imipramine therapy in bladder exstrophy after bladder neck reconstruction

The role of imipramine therapy in bladder exstrophy after bladder neck reconstruction

In Vitro Intravesical Instillation of Anticholinergic, Antispasmodic and Calcium Blocking Agents (Rabbit Whole Bladder Model)

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