Functional dyspepsia: relationship between clinical subgroups and Helicobacter pylori status in Western Turkey

Abstract

The etiology of functional dyspepsia is not known. The objective of the present study was to determine the characteristics of functional dyspepsia in Western Turkey. We divided 900 patients with functional dyspepsia into three subgroups according to symptoms: ulcer-like (UL), 321 (35.6%), motility disorder-like (ML), 281 (31.2%), and the combination (C) of these symptoms, 298 (33.1%). All patients were submitted to endoscopic evaluation, with two biopsies taken from the cardia and corpus, and four from the antrum of the stomach. All biopsy samples were studied for Helicobacter pylori (Hp) density, chronic inflammation, activity, intestinal metaplasia, atrophy, and the presence of lymphoid aggregates by histological examination. One antral biopsy was used for the rapid urease test. Tissue cagA status was determined by PCR from an antral biopsy specimen by a random sampling method. We also determined the serum levels of tumor necrosis factor-α (TNF-α) and gastrin by the same method. Data were analyzed statistically by the Kolmogorov-Smirnov test and by analysis of variance. Hp and cagA positivity was significantly higher in the UL subgroup than in the others. The patients in the ML subgroup had the lowest Hp and cagA positivity and Hp density. The ML subgroup also showed the lowest level of Hp-induced inflammation among all subgroups. The serum levels of TNF-α and gastrin did not reveal any difference between groups. Our findings show a poor association of Hp with the ML subgroup of functional dyspepsia, but a stronger association with the UL and C subgroups.

Evaluation of Dietary and Life-Style Habits of Patients with Gastric Cancer: A Case-Control Study in Turkey

“…Distal gastric cancer incidence is higher in developing countries because of higher rate of H. pylori infection in these countries. The prevalance of H. pylori in Turkey is reported to be 38.5%-78.5% in different studies (Saruç et al, 2003;Özden et al, 2004;Sari et al, 2007). In our study, H. pylori was tested only in patients with gastric cancer and 81.3% of the patients were found to be H. pylori positive.…”

Helicobacter pylori and histopathological findings in patients with dyspepsia

“…Although Hp infection has been reported to be more frequent in patients with dyspepsia, its relationship with gastric cancer and whether or not it should be treated in dyspepsia are still controversial (8)(9)(10)(11)(12)(13)(14)(15). In an effort to resolve these questions, we studied the histopathological changes in Hppositive and -negative dyspepsia patients.…”

Polikistik over sendromlu kadınlarda, Roma III teşhis kriterlerine göre fonksiyonel dispepsi sıklığı

“…Çalışmamızda FD sıklığı, PKOS'lu hastalarda %53 iken sağlıklı kontrol deneklerde %28.4 saptandı. Türk toplumunda normal popülasyonda yapılan çalışmada FD sıklığı %31-35 idi ve çalışmamızda sağlıklı kontrol deneklerde literatüre benzer sıklıkta bulundu (11).…”