Functional Dyspepsia

Kerkhoven, Lieke A. S. van; Laheij, R.J.F.; Meineche-Schmidt, Villy; Zanten, Sander J. Veldhuyzen-van; Wit, Niek J. de; Jansen, J. B. M. J.

doi:10.1097/mcg.0b013e31815591f7

Cited by 48 publications

(12 citation statements)

References 29 publications

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“…However, not every patient fits perfectly into each category and therefore, results may not accurately correspond to the patient pool presenting in the clinics. [8] The present study is the direct evaluation of discriminative value of Rome III questionnaire for FD in clinical setting. Our data suggests that Rome III questionnaire for FD was able to correctly place patients with dyspeptic symptoms into the FD category two out of three times in a clinical setting when this criteria was applied to patients with uninvestigated dyspepsia.…”

Section: Discussionmentioning

confidence: 99%

Discriminant value of Rome III questionnaire in dyspeptic patients

Abid

Siddiqui

Jafri

2011

Saudi J Gastroenterol

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Background/Aim:Rome III criteria has modified the description of functional dyspepsia (FD) and divided this into subgroups. However, the discriminative value of Rome III questionnaire-based diagnosis of FD is yet to be determined. Objectives: To evaluate the Rome III questionnaire for the diagnosis of FD and whether it can discriminate between postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS) in patients with dyspeptic symptoms.Patients and Methods:Consecutive patients, who were not on proton pump inhibitors (PPI), were asked to participate. Patients who have previously established acid peptic disease or predominantly reflux symptoms or having alarm symptoms such as weight loss and hematemesis were excluded. Rome III questionnaire for FD was used to identify the patients as having FD and divide into its subgroups; PDS or EPS. Gastro-duodenal biopsies, liver function tests and ultrasound were done to establish the diagnosis of FD.Results:Out of 272 patients with upper gastrointestinal (GI) symptoms without alarm features, who were enrolled in the study, a total of 191 (70%) fulfilled the criteria of FD based upon Rome III questionnaire. EPS subgroup was found in 109 (57%), PDS in 17 (9%) patients, overlap between EPS and PDS was present in 56 (29%) patients. Nine (5%) patients remained indeterminate. Diagnosis of FD was established in 136/191 (71%) patients only. Gastritis was present in 116 patients (85%), Duodenitis in 44 (32%) and Helicobacter pylori infection in 70 (51%) patients. Among 55 patients (29%) who had organic diseases, EPS was seen in 35 (64%), PDS in 5 (9%) and overlap in 15 (27%) patients. Underlying organic causes were gastric or duodenal ulcers in 14 patients, Barrett esophagus in five, chronic liver disease in seven, gall stones in five, Giardiasis and celiac disease in three each. Gastric carcinoma, Crohns disease and gastric polyps were seen in one patient each.Conclusion:This study indicates that 30% of patients who fulfilled the Rome III criteria for FD actually had organic disease. Almost one-third of patients with functioanl dyspepsia did not qualify for one of the two subgroups of FD of Rome III. There is also a need to further define the Rome III-based subgroups of FD for research purpose.

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Section: Discussionmentioning

confidence: 99%

Discriminant value of Rome III questionnaire in dyspeptic patients

Abid

Siddiqui

Jafri

2011

Saudi J Gastroenterol

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“…Recent epidemiological studies have provided indirect and mixed evidence on the dimensional or categorical nature of FD. Studies in healthcare‐seeking samples showed major overlap between EPS and PDS subgroups, pointing toward a dimensional structure of FD, whereas studies in population‐based samples indicated a good separation of both subgroups, suggesting a categorical structure . Studies on differential involvement of genetic polymorphisms and pathophysiological mechanisms, including gastric sensorimotor function, immune function, Helicobacter pylori infection and psychobiological processes in both subgroups have also yielded mixed results .…”

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confidence: 99%

“…Studies in healthcare-seeking samples showed major overlap between EPS and PDS subgroups, pointing toward a dimensional structure of FD, whereas studies in population-based samples indicated a good separation of both subgroups, suggesting a categorical structure. [8][9][10][11] Studies on differential involvement of genetic polymorphisms and pathophysiological mechanisms, including gastric sensorimotor function, immune function, Helicobacter pylori infection and psychobiological processes in both subgroups have also yielded mixed results. 2 Finally, confirmatory factor analyses (CFA) on dyspepsia symptom questionnaires both in the general population and in tertiary care have confirmed the existence of separate but correlated 'EPS', 'PDS', and 'nausea/vomiting' factors.…”

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confidence: 99%

The latent structure of the functional dyspepsia symptom complex: a taxometric analysis

Oudenhove

Jasper

Walentynowicz

et al. 2016

Neurogastroenterology Motil

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“…The inclusive definition of dyspepsia used in the LDQ, which include symptoms of GERD as well, may appear to conflict with the Rome process [ 32 ]. However, the Rome definition of dyspepsia, and its requisite of excluding any symptoms of GERD, has been criticised for excluding many patients with genuine FD in both Asian [ 33 ] and non-Asian communities [ 34 ]. It has even less applicability for uninvestigated dyspepsia in the community, where both reflux symptoms and epigastric pain commonly coexist.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Dyspepsia on Symptom Severity and Quality of Life in Adults with Headache

et al. 2015

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BackgroundDyspepsia and headache frequently co-exist, but the clinical implication of this association is uncertain. We planned to examine the prevalence and impact of dyspepsia in adults with headache.MethodsA cross-sectional study was conducted in a secondary care setting. Clinical, psychological and health-related quality of life (HRQOL) data were compared between subjects with headache and controls (non-headache subjects). The impact of dyspepsia was analysed further in subjects with headache alone.Results280 subjects (93 cases with headache and 187 matched controls) were recruited. The following baseline characteristics of subjects were as follows: mean age 45.0±17.3 years, 57.0% females and ethnic distribution—Malaysian = 45 (48.4%), Chinese n = 24 (25.8%) and Indians n = 24 (25.8%). Headache sub-types among cases with headache were as follows: tension-type headache (TTH) n = 53 (57.0%) and migraine n = 40 (43.0%). Dyspepsia was more prevalent in cases with headache compared to controls (25.8% vs 12.8%, p = 0.011), and headache was independently associated with dyspepsia (OR 2.75, 95% CI 1.39–5.43). Among cases with headache, there was a trend towards a higher prevalence of dyspepsia in those with migraine (27.5%) compared to TTH (24.5%). Subjects with headache and dyspepsia, compared to those with headache alone, had a greater severity of headache symptoms (63.67±22.85 mm vs 51.20 ±24.0 mm VAS, p = 0.029). Overall HRQOL scores were lower in headache subjects with dyspepsia (EQ-5D summary score 0.82±0.18 vs 0.90 ±0.16, p = 0.037 and EQ-5D VAS 62.08±17.50 mm vs 72.62 ±18.85 mm, p = 0.018), compared to those without dyspepsia.ConclusionDyspepsia is associated with more severe headache symptoms and results in a lower HRQOL in patients with headache.

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Functional Dyspepsia

Abstract: The symptom-based Rome classification of functional dyspepsia does not lead to an easily applicable and consistent system that is useful in clinical practice or scientific research.

Cited by 48 publications

References 29 publications

Discriminant value of Rome III questionnaire in dyspeptic patients

Discriminant value of Rome III questionnaire in dyspeptic patients

The latent structure of the functional dyspepsia symptom complex: a taxometric analysis

The Impact of Dyspepsia on Symptom Severity and Quality of Life in Adults with Headache

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