Functional downregulation of the neurokinin 1 receptor by antidepressant, neuroleptics and mood stabilizers

Herpfer, Inga; Fiebich, Bernd L.; Singewald, Nicolas; Hamke, Maike; Lieb, K

doi:10.1055/s-2005-918712

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“…Both central and peripheral levels of SP are elevated in some depressed patients (Bondy et al, 2003; Geracioti et al, 2006; Rimón et al, 1984), and successful antidepressant activity of several classes of antidepressants has been associated with a reduction in these levels (Bondy et al, 2003; Husum et al, 2001; Lieb et al, 2004; Olsson et al, 2004; Shirayama et al, 1996). In addition, antidepressant treatment has been shown to downregulate NK-1r expression in the brain (Herpfer, Fiebich, et al, 2005) and may attenuate stress-induced increases in SP levels in some brain regions (described in Ebner & Singewald, 2006). More general claims about the impact of antidepressants on the central SP–NK-1r system are difficult to make because the data are inconsistent (see Ebner & Singewald, 2006, for a review).…”

Section: Emotion Stress and Diseases Of Chronic Inflammationmentioning

confidence: 99%

Substance P at the nexus of mind and body in chronic inflammation and affective disorders.

Rosenkranz

2007

Psychological Bulletin

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For decades, research has demonstrated that chronic diseases characterized by dysregulation of inflammation are particularly susceptible to exacerbation by stress and emotion. Likewise, rates of depression and anxiety are overrepresented in individuals suffering from chronic inflammatory disease. In recent years, substance P has been implicated in both the pathophysiology of inflammatory disease and the pathophysiology of depression and anxiety by 2 parallel fields of study. This review integrates the literature from these 2 parallel fields and examines the possibility that substance P dysregulation may be a point of convergence underlying the overlap of chronic inflammatory disease and mood and anxiety disorders. First, the involvement of substance P in peripheral inflammation and in the immune events associated with chronic inflammatory disease is discussed, with a focus on inflammatory bowel disease and asthma. Next, the function of substance P in the communication of peripheral inflammation to the brain is considered. Finally, to complete the bidirectional loop of brain-immune interactions, substance P expression in anxiety and depression as well as its potential role in the neural regulation of peripheral inflammation is reviewed.

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Section: Emotion Stress and Diseases Of Chronic Inflammationmentioning

confidence: 99%

Substance P at the nexus of mind and body in chronic inflammation and affective disorders.

Rosenkranz

2007

Psychological Bulletin

View full text Add to dashboard Cite

show abstract

Functional downregulation of the neurokinin 1 receptor by antidepressant, neuroleptics and mood stabilizers

Cited by 1 publication

References 0 publications

Substance P at the nexus of mind and body in chronic inflammation and affective disorders.

Substance P at the nexus of mind and body in chronic inflammation and affective disorders.

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