Functional domains of the human glucocorticoid receptor

Giguère, Vincent; Hollenberg, Stanley M.; Rosenfeld, Michael G.; Evans, Ronald M.

doi:10.1016/0092-8674(86)90339-9

Cited by 874 publications

(410 citation statements)

References 31 publications

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“…It was observed that the regions comprise a number of functional domains (Giguere et al, 1986;Carlstedt-Duke et al, 1987;Hollenberg et al, 1987;Rusconi and Yamamoto, 1987): (1) The C-terminal steroid binding domain (220-250 amino acid residues), which probably contains a pocket into which the ligand fits. Contained in this area is also one of the dimerization domains and the HSP90 association site.…”

Section: Primary Structurementioning

confidence: 99%

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Mineralocorticoid and glucocorticoid receptors in the brain. Implications for ion permeability and transmitter systems

Joëls

Kloet

1994

Progress in Neurobiology

367

168

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Section: Primary Structurementioning

confidence: 99%

“…Transactivational domains were identified in the C-terminal and N-terminal regions of the receptor (Giguere et al, 1986;Webster et al, 1988;Hollenberg and Evans, 1988;Pearce and Yamamoto, 1993). These domains are important determinants of the final transcriptional efficacy (Arriza et al, 1988).…”

Section: Primary Structurementioning

confidence: 99%

Mineralocorticoid and glucocorticoid receptors in the brain. Implications for ion permeability and transmitter systems

Joëls

Kloet

1994

Progress in Neurobiology

367

168

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“…The structural organization of the GR protein is well known (12,13). GR contains three functional domains: the NH 2 -terminal part or modulating domain involved in modulation of gene transcription (14); the DNA-binding domain involved in DNA binding, receptor dimerization (15), and gene transcription enhancement (16); and the ligand-binding domain that controls the activity of the receptor as a whole through its interaction with other proteins and glucocorticoids.…”

Section: Introductionmentioning

confidence: 99%

Glucocorticoid receptor transcriptional isoforms and resistance in multiple myeloma cells

Sánchez-Vega

Krett

Rosen

et al. 2006

Molecular Cancer Therapeutics

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Although glucocorticoids play an important role in the treatment of multiple myeloma, some patients do not respond or develop resistance. The glucocorticoid receptor (GR), a single gene, mediates the effects of glucocorticoids. Using a model system of a multiple myeloma cell line sensitive to glucocorticoids and its early and late resistant variants, we have analyzed mutations in the GR gene, detected the presence of different transcriptional isoforms, quantified their levels of expression, and identified the promoters that regulate their expression.

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“…O GR está amplamente distribuído pelo cérebro e tecidos periféricos. No estado inativo, o GR é parte de um complexo multiprotéico consistindo de várias moléculas de proteínas de choque térmico [41][42][43] . Ligando-se aos glicocorticóides, o GR transloca-se para o núcleo da célula, onde interage com elementos responsivos aos glicocorticóides específicos no ADN, de modo a alterar a transcrição de determinados genes 44 .…”

Section: O Eixo Hipotálamo-hipófise-adrenal No Início Da Vida E Mecanunclassified

Developmental Origins of Health and Disease (DOHaD)

2006

Early Human Development

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ResumoObjetivo: Apresentar um novo ramo da ciência, denominado origens desenvolvimentistas da saúde e doença (DOHaD), abordando conceitos, métodos de estudo, aspectos éticos e perspectivas para essa área do conhecimento. Fontes dos dados:Revisão não sistemática da literatura biomédica, com o intuito de obter referências históricas e atualizadas relacionadas com o tema em discussão. Síntese dos dados:Estudos recentes demonstram associações entre agravos ocorridos em fases iniciais do desenvolvimento somático e a amplificação do risco para doenças crônicas ao longo da vida, tais como obesidade, diabetes e doenças cardiovasculares. Diferentes modelos foram propostos na tentativa de melhor explicar essas associações, como a teoria do fenótipo poupador, a programação, as respostas adaptativas preditivas e o conceito de concordância ou contraste. Alguns dos possíveis mecanismos envolvidos nesses processos são: efeitos do ambiente sobre a expressão gênica, através de mecanismos epigenéticos; efeitos de sinais hormonais transmitidos ao feto através da placenta ou ao recém-nascido através da lactação. Conclusões:O DOHaD agrega informações advindas de várias áreas do conhecimento, propondo novas metodologias de investigação no sentido de esclarecer a influência de eventos adversos ocorridos em fases precoces do desenvolvimento humano sobre o padrão de saúde e doença ao longo da vida. Esse novo campo da ciência propõe novos modelos de causalidade e mecanismos envolvidos no surgimento e desenvolvimento de doenças crônicas. Os resultados dessas investigações poderão resultar em impacto significativo na prevenção de doenças crônicas, bem como na promoção de saúde em diferentes fases da vida.J Pediatr (Rio J). 2007;83(6):494-504: DOHaD, programação, hipótese de Barker. AbstractObjective: To present a new branch of scientific knowledge, known as the developmental origins of health and disease (DOHaD), covering its concepts, study methods and ethical considerations in addition to the prospects for this area of knowledge. Sources:A non-systematic review of the biomedical literature intended to identify historical and current references related to the subject under discussion. Summary of the findings:Recent studies demonstrate associations between aggressions suffered during the initial phases of somatic development and amplified risk of chronic diseases throughout life, such as obesity, diabetes and cardiovascular diseases. A variety of models have been proposed in attempts to better explain these associations, such as the thrifty phenotype, programming and predictive adaptive response theories and the concept of match or mismatch. Some of the mechanisms possibly involved in these processes are: effects of the environment on gene expression, through epigenetic mechanisms; effects of hormonal signals transmitted to the fetus via the placenta or the newborn via lactation.Conclusions: DOHaD draws together information originating from many different areas of knowledge, proposing new investigative methodologies to elucidate the influe...

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Functional domains of the human glucocorticoid receptor

Cited by 874 publications

References 31 publications

Mineralocorticoid and glucocorticoid receptors in the brain. Implications for ion permeability and transmitter systems

Mineralocorticoid and glucocorticoid receptors in the brain. Implications for ion permeability and transmitter systems

Glucocorticoid receptor transcriptional isoforms and resistance in multiple myeloma cells

Developmental Origins of Health and Disease (DOHaD)

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