‘Functional DNA array’ in the fly: implication for neuronal degeneration

Kanuka, Hirotaka; Miura, Masayuki

doi:10.1038/sj.cdd.4400985

Cell Death Differ

2002

DOI: 10.1038/sj.cdd.4400985

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‘Functional DNA array’ in the fly: implication for neuronal degeneration

Hirotaka Kanuka

Masayuki Miura

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Cited by 2 publications

(1 citation statement)

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“…We used a technique for genetic screening in Drosophila to identify gene products that can cause neural death or degeneration (4,5) and revealed that one of these gene products, a homologue of Sec61␣ translocon, plays a critical role in neural cell death and degeneration (H.K. and M.M., unpublished data).…”

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confidence: 99%

Cytosol-endoplasmic reticulum interplay by Sec61α translocon in polyglutamine-mediated neurotoxicity in Drosophila

Kanuka

Kuranaga

Hiratou

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

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Intracellular deposition of aggregated and ubiquitinated proteins is a prominent cytopathological feature of most neurodegenerative disorders frequently correlated with neural cell death. To elucidate mechanisms in neural cell death and degeneration, we characterized the Drosophila ortholog of Sec61␣ (DSec61␣), a component of the translocon that is involved in both protein import and endoplasmic reticulum-associated degradation. Lossof-function experiments for DSec61␣ revealed that the translocon contributes to expanded polyglutamine-mediated neuronal toxicity, likely resulting from proteasome inhibition and leading to accumulation of ubiquitinated proteins. Taken together, proteasome inhibition by expanded polyglutamine tracts may lead to the accumulation of toxic undegraded proteins normally transported by the Sec61␣ translocon.

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confidence: 99%

Cytosol-endoplasmic reticulum interplay by Sec61α translocon in polyglutamine-mediated neurotoxicity in Drosophila

Kanuka

Kuranaga

Hiratou

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

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Gain-of-function screen identifies a role of the Sec61α translocon in Drosophila postmitotic neurotoxicity

Kanuka

Hiratou

Igaki

et al. 2005

Biochimica et Biophysica Acta (BBA) - General Subjects

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‘Functional DNA array’ in the fly: implication for neuronal degeneration

Cited by 2 publications

References 19 publications

Cytosol-endoplasmic reticulum interplay by Sec61α translocon in polyglutamine-mediated neurotoxicity in Drosophila

Cytosol-endoplasmic reticulum interplay by Sec61α translocon in polyglutamine-mediated neurotoxicity in Drosophila

Gain-of-function screen identifies a role of the Sec61α translocon in Drosophila postmitotic neurotoxicity

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