Functional diversity and specificity of neostriatal interneurons

Tepper, James M.; Bolam, J. Paul

doi:10.1016/j.conb.2004.10.003

Cited by 461 publications

(422 citation statements)

References 47 publications

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“…Analysis of 3‐month‐old wild‐type mice revealed a prominent but widely distributed expression of Shh in cortical and SN brain areas and a highly restricted expression of Shh in the striatum (Figure 4c). Shh signal was limited to cells with large nuclei and was evenly distributed in the striatum (Figure 4c), two characteristics that are shared by both ACh and FS (Tepper & Bolam, 2004). To confirm the contribution of these interneurons to the striatal production of Shh, we conditionally deleted Shh in ACh or FS ( Chat Cre/+ ; Shh loxP/loxP –ChAT‐Shh– and Pv Cre/+ ; Shh loxP/loxP –PV‐Shh–) and showed a significant reduction in the Shh mRNA levels in the striatum in both mouse models (Figure 4d,e) using qRT–PCR.…”

Section: Resultsmentioning

confidence: 97%

Substantia nigra dopaminergic neurons and striatal interneurons are engaged in three parallel but interdependent postnatal neurotrophic circuits

Sanchez-Garcia

Nieto-González

García-Junco-Clemente

et al. 2018

Aging Cell

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The striatum integrates motor behavior using a well‐defined microcircuit whose individual components are independently affected in several neurological diseases. The glial cell line‐derived neurotrophic factor (GDNF), synthesized by striatal interneurons, and Sonic hedgehog (Shh), produced by the dopaminergic neurons of the substantia nigra (DA SNpc), are both involved in the nigrostriatal maintenance but the reciprocal neurotrophic relationships among these neurons are only partially understood. To define the postnatal neurotrophic connections among fast‐spiking GABAergic interneurons (FS), cholinergic interneurons (ACh), and DA SNpc, we used a genetically induced mouse model of postnatal DA SNpc neurodegeneration and separately eliminated Smoothened (Smo), the obligatory transducer of Shh signaling, in striatal interneurons. We show that FS postnatal survival relies on DA SNpc and is independent of Shh signaling. On the contrary, Shh signaling but not dopaminergic striatal innervation is required to maintain ACh in the postnatal striatum. ACh are required for DA SNpc survival in a GDNF‐independent manner. These data demonstrate the existence of three parallel but interdependent neurotrophic relationships between SN and striatal interneurons, partially defined by Shh and GDNF. The definition of these new neurotrophic interactions opens the search for new molecules involved in the striatal modulatory circuit maintenance with potential therapeutic value.

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Section: Resultsmentioning

confidence: 97%

Substantia nigra dopaminergic neurons and striatal interneurons are engaged in three parallel but interdependent postnatal neurotrophic circuits

Sanchez-Garcia

Nieto-González

García-Junco-Clemente

et al. 2018

Aging Cell

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“…Our contribution to this precise point is that, in all the variations of WTA obtained with both the CBG and GPR structures, this connection grieves the supposed functionality. To explain this result, we can conceive three non-contradictory hypothesis : (1) both the CBG and GPR lack in the modeling of a (perhaps unknown) fundamental connection or property enabling the GP e → GP i to contribute to a WTA algorithm; (2) the BG is performing another function which gives meaning to this connection; (3) in accordance with electrophysiological data, this connection is effectively weak.…”

Section: Model Comparisonmentioning

confidence: 99%

“…The Str comprises mostly medium spiny neurons (MSN) and, more marginally, different types of interneurons, among which the fast-spiking interneurons (FSI) received special attention [3]. MSN are commonly subdivided on the basis of the presence of D1 or D2 dopamine receptors, distinguishing a striato-pallidal and a striatonigral pathway [4].…”

Section: Introductionmentioning

confidence: 99%

Multi-objective Evolutionary Algorithms to Investigate Neurocomputational Issues: The Case Study of Basal Ganglia Models

Liénard

Guillot

Girard

2010

From Animals to Animats 11

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Abstract. The basal ganglia (BG) are a set of subcortical nuclei involved in action selection processes. We explore here the automatic parameterization of two models of the basal ganglia (the GPR and the CBG) using multi-objective evolutionary algorithms. We define two objective functions characterizing the supposed winner-takes-all functionality of the BG and obtain a set of solutions lying on the Pareto front for each model. We show that the CBG architecture leads to solutions dominating the GPR ones, this highlights the usefulness of the CBG additional connections with regards to the GPR. We then identify the most satisfying solutions on the fronts in terms of both functionality and plausibility. We finally define critical and indifferent parameters by analyzing their variations and values on the fronts, helping us to understand the dynamics governing the selection process in the BG models.

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“…Striatal acetylcholine (ACh), and its interplay with DA, has long been recognized as playing a crucial role in voluntary movement (Duvoisin, 1967). In the striatum, ACh is mainly released by a population of large aspiny interneurons (LAIs) (Phelps et al, 1985;Zhou et al, 2002;Tepper and Bolam, 2004). Pakhotin and Bracci (2007) have shown that LAIs exerted a strong inhibitory control over the neighbouring striatal MSNs via inhibition of their GLUergic input.…”

Section: -Ht Modulation Of Striatal Activitymentioning

confidence: 99%

Serotonin modulation of the basal ganglia circuitry: therapeutic implication for Parkinson's disease and other motor disorders

Matteo

Pierucci

Esposito

et al. 2008

Progress in Brain Research

133

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Several recent studies have emphasized a crucial role for the interactions between serotonergic and dopaminergic systems in movement control and the pathophysiology of basal ganglia. These observations are supported by anatomical evidence demonstrating large serotonergic innervation of all the basal ganglia nuclei. In fact, serotonergic terminals have been reported to make synaptic contacts with both substantia nigra dopamine-containing neurons and their terminal areas such as the striatum, the globus pallidus and the subthalamus. These brain areas contain a high concentration of serotonin (5-HT), with the substantia nigra pars reticulata receiving the greatest input. In this chapter, the distribution of different 5-HT receptor subtypes in the basal ganglia nuclei will be described. Furthermore, evidence demonstrating the serotonergic control of basal ganglia activity will be reviewed and the contribution of the different 5-HT receptor subtypes examined. The new avenues that the increasing knowledge of 5-HT in motor control has opened for exploring the pathophysiology and pharmacology of Parkinson's disease and other movement disorders will be discussed. It is clear that these avenues will be fruitful, despite the disappointing results so far obtained by clinical studies with selective 5-HT ligands. Nevertheless, these studies have led to a great increase in the attention given to the neurotransmitters of the basal ganglia and their connections.

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Functional diversity and specificity of neostriatal interneurons

Cited by 461 publications

References 47 publications

Substantia nigra dopaminergic neurons and striatal interneurons are engaged in three parallel but interdependent postnatal neurotrophic circuits

Substantia nigra dopaminergic neurons and striatal interneurons are engaged in three parallel but interdependent postnatal neurotrophic circuits

Multi-objective Evolutionary Algorithms to Investigate Neurocomputational Issues: The Case Study of Basal Ganglia Models

Serotonin modulation of the basal ganglia circuitry: therapeutic implication for Parkinson's disease and other motor disorders

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