Functional Distribution and Regulation of the NMDAR in the Kidney, Heart and Parathyroid Gland

Božić, Milica; Valdivielso, José M.

doi:10.1007/978-3-319-49795-2_3

Cited by 3 publications

(3 citation statements)

References 81 publications

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“…In the last decade, there has been an increasing body of data demonstrating the role of NMDAR in the glomerular and tubular function ( Figure 2 ). It is evident that basal degree of NMDAR activation is essential for the preservation of normal tubular and glomerular function, while a disproportionate activation can provoke a disruption of renal homeostasis, leading to a diversity of pathophysiological sequels seen as structural and functional organ impairment [ 23 , 82 ].…”

Section: Distinctive Physiological and Pathophysiological Roles Ofmentioning

confidence: 99%

Glutamate-Gated NMDA Receptors: Insights into the Function and Signaling in the Kidney

et al. 2020

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N-Methyl-d-aspartate receptor (NMDAR) is a glutamate-gated ionotropic receptor that intervenes in most of the excitatory synaptic transmission within the central nervous system (CNS). Aside from being broadly distributed in the CNS and having indispensable functions in the brain, NMDAR has predominant roles in many physiological and pathological processes in a wide range of non-neuronal cells and tissues. The present review outlines current knowledge and understanding of the physiological and pathophysiological functions of NMDAR in the kidney, an essential excretory and endocrine organ responsible for the whole-body homeostasis. The review also explores the recent findings regarding signaling pathways involved in NMDAR-mediated responses in the kidney. As established from diverse lines of research reviewed here, basal levels of receptor activation within the kidney are essential for the maintenance of healthy tubular and glomerular function, while a disproportionate activation can lead to a disruption of NMDAR’s downstream signaling pathways and a myriad of pathophysiological consequences.

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Section: Distinctive Physiological and Pathophysiological Roles Ofmentioning

confidence: 99%

Glutamate-Gated NMDA Receptors: Insights into the Function and Signaling in the Kidney

et al. 2020

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“…The glutamate-regulated N-methyl-D-aspartate receptor (NMDAR) is a glutamate-gated nonselective cation channel that is highly expressed in the kidneys, in addition to being widely expressed in the central nervous system [ 57 , 58 ]. Multiple reports have suggested that NMDAR plays an important role in maintaining renal homeostasis [ 58 , 59 ], and that its overexpression or inhibition may cause renal homeostasis imbalance and lead to the occurrence of renal disease. Studies have shown that the regulation of NMDAR agonists can change the GFR and the GFR of mononephron units [ 60 , 61 ], so it is speculated that the change of glutamate on NMDAR regulation may play an important role in ARC genesis.…”

Section: Discussionmentioning

confidence: 99%

LC-MS/MS-Based Serum Metabolomics and Transcriptome Analyses for the Mechanism of Augmented Renal Clearance

Wang

Yi-Fan

Shu

et al. 2023

IJMS

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Augmented Renal Clearance (ARC) refers to the increased renal clearance of circulating solute in critically ill patients. In this study, the analytical research method of transcriptomics combined with metabolomics was used to study the pathogenesis of ARC at the transcriptional and metabolic levels. In transcriptomics, 534 samples from 5 datasets in the Gene Expression Omnibus database were analyzed and 834 differential genes associated with ARC were obtained. In metabolomics, we used Ultra-Performance Liquid Chromatography-Quadrupole Time-of-Flight Mass Spectrometry to determine the non-targeted metabolites of 102 samples after matching propensity scores, and obtained 45 differential metabolites associated with ARC. The results of the combined analysis showed that purine metabolism, arginine biosynthesis, and arachidonic acid metabolism were changed in patients with ARC. We speculate that the occurrence of ARC may be related to the alteration of renal blood perfusion by LTB4R, ARG1, ALOX5, arginine and prostaglandins E2 through inflammatory response, as well as the effects of CA4, PFKFB2, PFKFB3, PRKACB, NMDAR, glutamate and cAMP on renal capillary wall permeability.

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“…The data showed that NMDAR antibodies are present in serum from patients with different types of dementia as well as from healthy elderly individuals. Although the origin and biological impact of NMDAR antibodies remain unresolved, the origin of these antibodies seems to be in the periphery because NMDARs are expressed in peripheral tissues [4].…”

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confidence: 99%

Biomarkers for Alzheimer’s disease: from pathogenesis to drug development

Hashimoto

2018

Eur Arch Psychiatry Clin Neurosci

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Functional Distribution and Regulation of the NMDAR in the Kidney, Heart and Parathyroid Gland

Cited by 3 publications

References 81 publications

Glutamate-Gated NMDA Receptors: Insights into the Function and Signaling in the Kidney

Glutamate-Gated NMDA Receptors: Insights into the Function and Signaling in the Kidney

LC-MS/MS-Based Serum Metabolomics and Transcriptome Analyses for the Mechanism of Augmented Renal Clearance

Biomarkers for Alzheimer’s disease: from pathogenesis to drug development

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