Functional Diffusion Map As an Early Imaging Biomarker for High-Grade Glioma: Correlation With Conventional Radiologic Response and Overall Survival

Hamstra, Daniel A.; Galbán, Craig J.; Meyer, Charles R.; Johnson, Timothy D.; Sundgren, Pia C.; Tsien, Christina; Lawrence, Theodore S.; Junck, Larry; Ross, David J.; Rehemtulla, Alnawaz; Ross, Brian D.; Chenevert, Thomas L.

doi:10.1200/jco.2007.15.2363

Cited by 256 publications

(223 citation statements)

References 42 publications

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“…The biologic basis for this finding remains unclear, but it can be speculated that a higher ADC is observed in necrotic tissue and in tissue with loss of cell membrane integrity, which may correspond to a more aggressive phenotype. It has also been reported that responding lesions show a significantly higher increase in ADC early after initiation of therapy than do nonresponding lesions (19)(20)(21)(22); this finding can be attributed to changes in cell density, resulting from cytotoxic therapy-induced necrosis or apoptotic processes. More studies with larger sample sizes are required to establish the utility of this technique in predicting overall survival or long-term disease-free survival.…”

Section: Clinical Applications and Limitations Of Dwi General Diagnosmentioning

confidence: 86%

“…The LSR or a similar measure has the potential to replace or complement the ADC for the characterization of lesions. On the other hand, when quantitative diffusion measurements are required (e.g., in the follow-up of lesions, such as in the early prediction of response to therapy (19)(20)(21)(22)), ADC measurements may still be preferred.…”

Section: Development Of Dwi: From the Brain To The Entire Bodymentioning

confidence: 99%

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Complementary Roles of Whole-Body Diffusion-Weighted MRI and¹⁸F-FDG PET: The State of the Art and Potential Applications

Kwee¹,

Takahara²,

Ochiai³

et al. 2010

J Nucl Med

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18 F-FDG PET is an established functional imaging modality for the evaluation of human disease. Diffusion-weighted MRI (DWI) is another rapidly evolving functional imaging modality that can be used to evaluate oncologic and nononcologic lesions throughout the body. The information provided by 18 F-FDG PET and DWI can be complementary, because the 2 methods are based on completely different biophysical underpinnings. This article will describe the basic principles, clinical applications, and limitations of DWI. In addition, the available evidence that correlates and compares 18 F-FDG PET and DWI will be reviewed. PET,usi ng the radiotracer 18 F-FDG, is an established functional imaging modality for a variety of oncologic and nononcologic (e.g., inflammatory and infectious) applications (1-3). The contribution of 18 F-FDG PET to medicine has been unmatched by any other functional imaging modality (4). At present, there is also growing interest in the application of diffusion-weighted MRI (DWI) in the body (5-7). DWI allows visualization and quantification of the mobility of water molecules and has many potential clinical applications. Importantly, although 18 F-FDG PET and DWI are both functional imaging modalities and provide a high lesion-to-background contrast, they are based on completely different biophysical and biochemical underpinnings. Therefore, the information provided by the 2 imaging modalities may be regarded as complementary. Given the developing applications of DWI, the increasing use of multimodality imaging (8), and the expected advent of fully integrated PET/MRI systems (9), knowledge of the characteristics, possibilities, and limitations of DWI technique is becoming increasingly important. This is true for both the imaging specialists and the clinicians who use these modalities. This article will review the basic principles, clinical applications, and limitations of DWI. Furthermore, the available evidence that correlates and compares 18 F-FDG PET with DWI will be reviewed.

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Section: Clinical Applications and Limitations Of Dwi General Diagnosmentioning

confidence: 86%

Section: Development Of Dwi: From the Brain To The Entire Bodymentioning

confidence: 99%

Complementary Roles of Whole-Body Diffusion-Weighted MRI and¹⁸F-FDG PET: The State of the Art and Potential Applications

Kwee¹,

Takahara²,

Ochiai³

et al. 2010

J Nucl Med

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“…6,7 ADC measured by DWI has been proposed as the technique of choice for detection of early response to treatment in brain tumors and head and neck cancers. [8][9][10] DWI is based on the diffusion of water molecules in tissue, which depends on the attenuation of cell membranes. The technique detects abnormalities based on differences in tissue cellularity.…”

Section: Methodsmentioning

confidence: 99%

Single-Shot Turbo Spin-Echo Diffusion-Weighted Imaging for Retinoblastoma: Initial Experience

Graaf¹,

Pouwels²,

Rodjan

et al. 2011

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Retinoblastoma may exhibit variable hyperintensities on DWI, resulting in different values in the ADC maps, depending on their histology and cellularity. However, EP-based DWI has susceptibility artifacts and image distortions, which make DWI of the orbit a challenging technique. The aim of this study was to investigate the feasibility of single-shot turbo spin-echo (HASTE) DWI in the evaluation of children with retinoblastoma and to assess the value of ADC maps in differentiating viable and necrotic tumor tissue.

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“…These fDMs were able to predict subsequent volumetric tumour response, as measured with standard radiographic criteria, suggesting early changes in tumour diffusion could be used as a prognostic marker. Subsequent work has shown that fDM when combined with conventional radiological response can provide a more accurate prediction of patient survival than either measure alone [21]. 1 H-MRS has also been shown to be a useful predictor of early treatment outcome following radiotherapy: the lactate/NAA ratio was a stronger prognostic factor for survival in malignant gliomas even more than patient age and tumour grade [22].…”

Section: Early Assessment Of Treatment Responsementioning

confidence: 99%

Diagnosis and treatment in neuro-oncology: an oncological perspective

Rees

2011

BJR

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ABSTRACT. Although brain tumours are rare compared with other malignancies, they are responsible, in many cases, for severe physical and cognitive disability and have a high case fatality rate (13% overall survival at 5 years). Gliomas account for over 60% of primary brain tumours and usually present with one or more symptoms of raised intracranial pressure, progressive neurological deficit, seizures, focal or global cognitive decline. The diagnosis is made by a combination of imaging and histological examination of tumour specimen. Contrast-enhanced MRI is the gold standard imaging modality and provides highly sensitive anatomical information about the tumour. Advanced imaging modalities provide complementary information about brain tumour metabolism, blood flow and ultrastructure and are being increasingly incorporated into routine clinical sequences. Imaging is essential for guiding surgery and radiotherapy treatments and for monitoring response to, and progression of, therapy. However, changes in imaging over time may be misinterpreted and lead to incorrect assumptions about the effectiveness of treatments. Thus, the disappearance of contrast enhancement and resolution of oedema after anti-angiogenesis treatments is seen early while conventional T 2 weighted/FLAIR sequences demonstrate continual tumour growth (pseudoregression). Conversely imaging may suggest lack of efficacy of treatment e.g. increasing tumour size and contrast enhancement following chemoradiation for malignant gliomas (pseudoprogression), which then stabilise or resolve after a few months of continued treatment and that paradoxically may be associated with a better outcome. These factors have led to a re-evaluation of the role of standard sequences in the assessment of treatment response spurning interest in the development of quantitative biomarkers.

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Functional Diffusion Map As an Early Imaging Biomarker for High-Grade Glioma: Correlation With Conventional Radiologic Response and Overall Survival

Abstract: Compared with conventional neuroimaging, fDM provided an earlier assessment of equal predictive value, and the combination of fDM and RR provided a more accurate prediction of patient survival than either metric alone.

Cited by 256 publications

References 42 publications

Complementary Roles of Whole-Body Diffusion-Weighted MRI and¹⁸F-FDG PET: The State of the Art and Potential Applications

Complementary Roles of Whole-Body Diffusion-Weighted MRI and¹⁸F-FDG PET: The State of the Art and Potential Applications

Single-Shot Turbo Spin-Echo Diffusion-Weighted Imaging for Retinoblastoma: Initial Experience

Diagnosis and treatment in neuro-oncology: an oncological perspective

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Functional Diffusion Map As an Early Imaging Biomarker for High-Grade Glioma: Correlation With Conventional Radiologic Response and Overall Survival

Abstract: Compared with conventional neuroimaging, fDM provided an earlier assessment of equal predictive value, and the combination of fDM and RR provided a more accurate prediction of patient survival than either metric alone.

Cited by 256 publications

References 42 publications

Complementary Roles of Whole-Body Diffusion-Weighted MRI and18F-FDG PET: The State of the Art and Potential Applications

Complementary Roles of Whole-Body Diffusion-Weighted MRI and18F-FDG PET: The State of the Art and Potential Applications

Single-Shot Turbo Spin-Echo Diffusion-Weighted Imaging for Retinoblastoma: Initial Experience

Diagnosis and treatment in neuro-oncology: an oncological perspective

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Product

Resources

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Complementary Roles of Whole-Body Diffusion-Weighted MRI and¹⁸F-FDG PET: The State of the Art and Potential Applications

Complementary Roles of Whole-Body Diffusion-Weighted MRI and¹⁸F-FDG PET: The State of the Art and Potential Applications