Functional differentiation in the dorsal hippocampus with local electrical stimulation during learning by rats

Livesey, P. J.; Meyer, Peter N.

doi:10.1016/0028-3932(75)90066-4

Cited by 49 publications

(4 citation statements)

References 7 publications

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“…A second point at which the lesion might have affected performance was during the reversal phase of the experiment. Many experiments have shown that rats with hippocampal lesions tend to perseverate, to respond on the basis of original training conditions when those conditions have been changed (e.g., Douglas, 1972; Livesey & Meyer, 1975; Livesey, Meyer, & Smith, 1980). However, the lesion animals in this experiment clearly did not do that.…”

Section: Methodsmentioning

confidence: 99%

Effects of intrahippocampal administration of colchicine on incentive contrast and on radial maze performance.

Flaherty¹,

Rowan-Szal²,

Emerich³

et al. 1989

Behavioral Neuroscience

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The behavior of rats given intradentate injections of the neurotoxin colchicine was examined in three experimental settings. In Experiment 1, colchicine-treated, artificial cerebrospinal fluid (CSF)-treated, and untreated animals did not differ in the intake of 32% and 4% sucrose solutions, nor did they differ in degree of successive negative contrast when the 32% solution was changed to 4% sucrose. In Experiment 2, the colchicine-treated and CSF-treated animals did not differ in degree of suppression in the intake of a 0.15% saccharin solution when it preceded 32% sucrose in once-daily pairings (anticipatory contrast), nor did they differ in reversal performance when saccharin-sucrose and saccharin-saccharin pairings were reversed. In Experiment 3, the colchicine-treated animals were substantially impaired in radial-arm maze performance compared with CSF-treated controls. These results suggest that a completely functioning hippocampus is not necessary for the memory of reward quality, the comparison of rewards, the suppression of behavior when reward is decreased, the formation of associations between two levels of reward, and the reversal of this association, as long as these processes are reflected in consummatory behavior. The data are interpreted in terms of differences between instrumental behavior and sensory memory and/or consummatory behavior--an interpretation that is not incompatible with a deficiency in working memory in the animals with lesions.

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Section: Methodsmentioning

confidence: 99%

Effects of intrahippocampal administration of colchicine on incentive contrast and on radial maze performance.

Flaherty¹,

Rowan-Szal²,

Emerich³

et al. 1989

Behavioral Neuroscience

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“…In our experiments, rats were involved in simultaneous discrimination of visual cues independent of spatial location, or in a successive go/no-go discrimination at one location. Disruption of specific aspects of learning and performance of these tasks was achieved with localized electrical (blocking) stimulation or with small lesions in the dorsal CA1 or underlying dentate gyms of the rat (Han and Livesey 1977;Livesey 1978;Livesey and Bayliss 1975;Livesey and Meyer 1975;Livesey and Wearne 1973).…”

Section: Department Of Psychology University Of Western Australia Nmentioning

confidence: 99%

Hippocampus, space, and memory

1979

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We examine two different descriptions of the behavioral functions of the hippocampal system. One emphasizes spatially organized behaviors, especially those using cognitive maps. The other emphasizes memory, particularly working memory, a short-term memory that requires iexible stimulus-response associations and is highly susceptible to interference. The predictive value of the spatial and memory descriptions were evaluated by testing rats with damage to the hippocampal system in a series of experiments, independently manipulating the spatial and memory characteristics of a behavioral task. No dissociations were found when the spatial characteristics of the stimuli to be remembered were changed; lesions produced a similar deficit in both spatial and nonspatial test procedures, indicating that the hippocampus was similarly involved regardless of the spatial nature of the task. In contrast, a marked dissociation was found when the memory requirements were altered. Rats with lesions were able to perform accurately in tasks that could be solved exclusively on the basis of reference memory. They performed at chance levels and showed no signs of recovery even with extensive postoperative training in tasks that required working memory. In one experiment all the characteristics of the reference memory and working memory procedures were identical except the type of memory required. Consequently, the behavioral dissociation cannot be explained by differences in attention, motivation, response inhibition, or the type of stimuli to be remembered. As a result of these experiments we propose that the hippocampus is selectively involved in behaviors that require working memory, irrespective of the type of material (spatial or nonspatial) that is to be processed by that memory.

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“…That is, theta may be a hippocampal electrical pattern initiated just prior to the onset of movement that sets the neuronal networks of the hippocampus to be ready for feedback information. Therefore, the theta response may reflect the activation of neural networks in the hippocampus that are necessary for the comparison process (Henderson & Greene, 1977;Livesey & Meyer, 1975;Numan, 1972;Numan et aI., 1975;Vinogradova, 1970Vinogradova, , 1975. The correlation with voluntary movement is seen to be a secondary consequence of activation of efference copy trace by actual or intended movement (for example, it is known that theta occurs in paralyzed animals; see Black, 1975, for review).…”

Section: Formulation Of a Model Of Response Controlmentioning

confidence: 99%

Cortical-limbic mechanisms and response control: A theoretical review

Numan

1978

Psychobiology

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The literature dealing with the behavioral effects produced by lesions of the septum, frontal cortical areas, and the hippocampus is reviewed. It is concluded that the dorsomedial septum, the dorsolateral frontal cortex (and homologous structures), and the dorsal hippocampus form a nodal point within a larger neuronal system that is involved in response regulation. A model describing the response regulatory processes mediated by this frontal cortical-limbic system is proposed. Motor programs are written in frontal cortex and temporarily stored in hippocampus. Feedback stimuli derived from response initiation and maintenance are compared against the stored hippocampal motor program. If the feedback information matches with the expected outcomes dictated by the motor program, the response sequence is terminated. If comparator deviations arise, the frontal cortical areas are signaled of error and a new motor program is written. Hippocampal theta activity is postulated to be a correlate of comparator activation and feedback analysis.

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Functional differentiation in the dorsal hippocampus with local electrical stimulation during learning by rats

Cited by 49 publications

References 7 publications

Effects of intrahippocampal administration of colchicine on incentive contrast and on radial maze performance.

Effects of intrahippocampal administration of colchicine on incentive contrast and on radial maze performance.

Hippocampus, space, and memory

Cortical-limbic mechanisms and response control: A theoretical review

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