Functional determinants of lysophospholipid- and voltage-dependent regulation of TRPC5 channel
Alexandra Ptakova,
Lucie Zimova,
Ivan Barvik
et al.
Abstract:Lysophosphatidylcholine (LPC) is a bioactive lipid present at high concentrations in inflamed and injured tissues where it contributes to the initiation and maintenance of pain. One of its important molecular effectors is the transient receptor potential canonical 5 (TRPC5), but the explicit mechanism of the activation is unknown. Using electrophysiology, mutagenesis and molecular dynamics simulations, we show that LPC-induced activation of TRPC5 is modulated by xanthine ligands and depolarizing voltage, and i… Show more
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