Functional degradation of extrastriate visual cortex in senescent rhesus monkeys

Yu, Shan; Wang, Y.; Li, X.; Zhou, Yifeng; Leventhal, Audie G.

doi:10.1016/j.neuroscience.2006.01.015

Cited by 99 publications

(92 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, some studies have shown that older adults are less able than younger adults to behaviorally distinguish between stimuli that are close in perceptual resemblance (Bartlett & Leslie, 1986;Betts et al, 2007;Goh et al, 2010a;Stark et al, 2010). It has been suggested that such agerelated reduction in distinctiveness of cognitive representations is due to a decrease in neural specificity and a broadening of neural tuning curves such that a given region that responds selectively in young adults will respond to a wider array of inputs in older adults (Goh et al, 2010a;Leventhal et al, 2003;Park & Reuter-Lorenz, 2009;Schmolesky et al, 2000;Wang et al, 2005;Yu et al, 2006). Indeed, Park et al (2004) presented pictures of faces, houses, pseudowords, chairs and scrambled controls to both older and young adults and acquired functional brain data as the participants passively viewed the stimuli.…”

Section: Reduced Distinctiveness Of Cognitive Representationsmentioning

confidence: 99%

Images of the Cognitive Brain Across Age and Culture

Goh¹,

Huang²

2012

Neuroimaging - Cognitive and Clinical Neuroscience

View full text Add to dashboard Cite

Section: Reduced Distinctiveness Of Cognitive Representationsmentioning

confidence: 99%

Images of the Cognitive Brain Across Age and Culture

Goh¹,

Huang²

2012

Neuroimaging - Cognitive and Clinical Neuroscience

View full text Add to dashboard Cite

“…Functional and neurochemical studies in animal models suggest that sensory aging may begin as a slow progressive peripheral deafferentation, which may trigger an activity-dependent compensatory down-regulation of central inhibitory neurotransmission (Caspary et al, 1990Schmolesky et al, 2000;Mendelson and Ricketts, 2001;Leventhal et al, 2003;Yu et al, 2006). Thus, clinically observed age-related central sensory processing deficits may be attributable at least in part, to decrements in inhibitory neurotransmission (Betts et al, 2007).…”

Section: Nih Public Accessmentioning

confidence: 99%

Aged-related loss of temporal processing: Altered responses to amplitude modulated tones in rat dorsal cochlear nucleus

2008

View full text Add to dashboard Cite

Loss of temporal processing is characteristic of age-related loss of speech understanding observed in the elderly. Inhibitory glycinergic circuits provide input onto dorsal cochlear nucleus (DCN) projection neurons which likely serve to modulate excitatory responses to time-varying complex acoustic signals. The present study sought to test the hypothesis that age-related loss of inhibition would compromise the ability of output neurons to encode sinusoidally amplitude modulated (SAM) tones. Extracellular recordings were obtained from young and aged FBN rat DCN putative fusiform cells. Stimuli were SAM tones at 3 modulation depths (100, 50, and 20%) at 30 dB HL with the carrier frequency set to the unit's characteristic frequency. Discharge rate and synchrony were calculated to describe SAM responses. There were significant age-related changes in the shape and peak vector strength [best modulation frequency (BMF)] of temporal modulation transfer functions (tMTFs), with no significant age-related changes in rate modulation transfer functions (rMTFs) at BMF. Young neurons exhibited band-pass tMTFs for most SAM conditions while aged fusiform cells exhibited significantly more low-pass or double-peaked tMTFs. There were significant differences in tMTFs between buildup, pauser-buildup, and wide-chopper temporal response types. Young and aged wide-choppers displayed significantly lower vector strength values than the other two temporal DCN response types. Age-related decreases in the number of pauser-buildup response types and increases in wide-chopper types with age reported previously, could account, in part, for the observed loss of temporal coding of the aged fusiform cell. Age-related changes in SAM coding were similar to changes observed with receptor blockade of glycinergic inhibition onto fusiform cells and consistent with previously observed age-related loss of endogenous glycine levels and changes in normal adult glycine receptor function. DCN changes in SAM coding could, in part, underpin temporal processing deficits observed in the elderly. KeywordsDorsal Cochlear Nucleus; Aging; Auditory; Glycine; Amplitude Modulation; Temporal Processing Presbycusis, age-related hearing loss, is a complex disorder that may result in a slow deterioration of peripheral auditory input to auditory regions of the brain (see Willott, 1991; Corresponding Author: Dr. Donald M. Caspary, Department of Pharmacology, Southern Illinois University School of Medicine, P.O. Box 19629, Springfield, IL 62794-9629. Phone: (217) 545-2195, Fax: (217) 545-0145, email: dcaspary@siumed.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal...

show abstract

“…目前, 我们发现与年龄相关的功能衰退可能是由细胞次级结构的改变所导致的。因为先前的大量实验表明猕猴和人类大脑皮层的细胞未发生丢失 (Morrison & Hof, 1997Peters et al, 1996Peters et al, , 1998Wong, 2002;Yu et al, 2006) (Habak & Faubert, 2000;Tran et al, 1998;Trick & Silverman, 1991;Willis & Anderson, 2000), 而这些运动知觉相关的功能依赖于大脑中的方向选择性细胞。我们发现的老年猕猴 MT 区细胞功能的衰退可能导致了运动知觉的衰退, 即 MT 区细胞的功能衰退可能是导致老年灵长类运动知觉退化的原因之一。参考文献：…”

unclassified