Functional deficits in menopause-associated encephalopathy: a behavioural rodent study.

Yu, Ming-Sum; D’Hooge, Rudi; Jeugd, Ann Van der

doi:10.3389/conf.fnins.2019.96.00043

Cited by 1 publication

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“…1). Similar www.nature.com/scientificreports/ to our data, OVX mice showed a significant decrease in novel-object recognition and were immobile during the forced swim test, reflecting depression-like behaviors and memory impairment 21,22 . These behavioral and cognitive alterations are evidenced by suppression of serotonin levels in the serum as well as in three brain regions, most prominently the hippocampus (Fig.…”

Section: Discussionsupporting

confidence: 88%

Linking alterations in estrogen receptor expression to memory deficits and depressive behavior in an ovariectomy mouse model

Baek,

Kang,

Lee

et al. 2024

Sci Rep

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The high risk of neurological disorders in postmenopausal women is an emerging medical issue. Based on the hypothesis of altered estrogen receptors (ERα and β) after the decline of estrogen production, we investigated the changes in ERs expressions across brain regions and depressive/amnesic behaviors. C57BL/6J female mice were ovariectomized (OVX) to establish a menopausal condition. Along with behavior tests (anxiety, depression, and memory), the expression of ERs, microglial activity, and neuronal activity was measured in six brain regions (hippocampus, prefrontal cortex, striatum, raphe nucleus, amygdala, and hypothalamus) from 4 to 12 weeks after OVX. Mice exhibited anxiety- and depressive-like behaviors, as well as memory impairment. These behavioral alterations have been linked to a suppression in the expression of ERβ. The decreased ERβ expression coincided with microglial-derived neuroinflammation, as indicated by notable activations of Ionized calcium-binding adapter molecule 1 and Interleukin-1beta. Additionally, the activity of brain-derived neurotrophic factor (BDNF), particularly in the hippocampus, decreased in a time-dependent manner from 4 to 12 weeks post-OVX. Our study provides evidence shedding light on the susceptibility to memory impairment and depression in women after menopause. This susceptibility is associated with the suppression of ERβ and alteration of ERα in six brain regions.

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Section: Discussionsupporting

confidence: 88%