Functional Data Analysis in NTCP Modeling: A New Method to Explore the Radiation Dose-Volume Effects

Benadjaoud, Mohamed Amine; Blanchard, Pierre; Schwartz, Boris; Champoudry, J.; Bouaita, Ryan; Lefkopoulos, Dimitri; Deutsch, Éric; Diallo, Ibrahima; Cardot, Hervé; Vathaire, Florent de

doi:10.1016/j.ijrobp.2014.07.008

Cited by 18 publications

(21 citation statements)

References 21 publications

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“…Detecting heterogeneous intraprostatic radiosensitivity. Our approach for detecting heterogeneous intraprostatic radiosensitivity was inspired by previous studies (25,34).…”

Section: Methodsmentioning

confidence: 99%

A Population-based Statistical Model for Investigating Heterogeneous Intraprostatic Sensitivity to Radiation Toxicity After ¹²⁵I Seed Implantation

Kobayashi¹,

Murakami

Takahashi

et al. 2019

In Vivo

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Aim: To develop a population-based statistical model in order to find a spatial pattern of dose distribution which is related to lower urinary tract symptoms (LUTS) after iodine-125 (125 I) seed implantation for prostate cancer. Patients and Methods: A total of 75 patients underwent 125 I seed implantation for prostate cancer. Principal component analysis was applied to the standardized dose array and for each patient dose distribution was uniquely characterized by a combination of weighted eigenvectors. The correlation between eigenvectors and the severity of LUTS was investigated with linear regression analysis. Results: Eight eigenvectors were identified as being significantly associated with the severity of LUTS (p<0.05). Multivariate regression model identified that intraprostatic parameters, which were positively associated with the severity of LUTS, were distributed around a portion of the urethral base and a peripheral region of the prostate. Conclusion: We established a population-based statistical model that may indicate a significant dose pattern associated with the severity of radiation toxicity.

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“…Detecting heterogeneous intraprostatic radiosensitivity. Our approach for detecting heterogeneous intraprostatic radiosensitivity was inspired by previous studies (25,34).…”

Section: Methodsmentioning

confidence: 99%

A Population-based Statistical Model for Investigating Heterogeneous Intraprostatic Sensitivity to Radiation Toxicity After ¹²⁵I Seed Implantation

Kobayashi¹,

Murakami

Takahashi

et al. 2019

In Vivo

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“…New radiotherapy machines driven by more sophisticated treatment planning systems will increase the ratio between toxicity to the organ at risk and sterilization of the tumor but it must be remembered that rectal adenocarcinoma is a quite radioresitant tumor. It has been shown that a dose of 92 Gy (2 Gy/fraction equivalent) is necessary to control only 50 % of T3 tumors [32•], and on the other hand, the maximum tolerable dose of the rectum is close to 75 Gy [33][34][35][36]. When considering these two opposite parameters, it is highly probable that mainly endocavitary well-targeted irradiations techniques (radioactive or X-ray brachytherapy and not teletherapy with external beam) will be able to achieve these balanced objectives [37][38][39][40][41].…”

Section: Neoadjuvant Treatments and Strategies To Improve Present Resmentioning

confidence: 99%

New Neoadjuvant Treatment Strategies for Non-Metastatic Rectal Cancer (M0)

Gérard

Doyen

Barbet

2015

Curr Colorectal Cancer Rep

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Rectal cancers stages II-III are presenting many various clinical situations. Neoadjuvant chemoradiotherapy is a standard of care in many cases, and in association with TME surgery, local relapses are becoming uncommon. None of these neoadjuvant treatments have so far improved survival, and quality of life remains non-optimal after abdominoperineal resection and quite often after anterior resection. To increase survival through sterilization of subclinical distant metastases, new induction chemotherapy is tested. In T4 tumors, radiation dose escalation should be able to further improve local control, and in elderly patients, reduction of nCRT toxicity may provide better compliance to TME surgery. A promising approach is the use of optimal neoadjuvant treatment in early tumors in order to achieve a clinical complete response and propose an organ preservation either after local excision or using a meticulous and prolonged watch and wait strategy. Well-conducted randomized trials will be necessary to modify the present standard of care.

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“…To the Editor: We appreciate the comments of Drs Alber and Sö hn on our article (1,2). The aim of our article was to propose flexible normal tissue complication probability modeling, to investigate the association between differential doseevolume histograms (dDVHs) and rectal bleeding.…”

Section: In Reply To Alber and Söhnmentioning

confidence: 99%

“…Two recent Surveillance, Epidemiology, and End Results (SEER) database analyses evaluated the underascertainment rates for adjuvant RT coding in breast cancer. Using patient surveys (2) and Medicare billing claims (3) as gold standards for true rates of RT delivery, these studies reported underascertainment rates of 21% and 19%, …”

Section: Considerations For Observational Researchmentioning

confidence: 99%

In Reply to Alber and Söhn

Benadjaoud

Vathaire

Blanchard

et al. 2015

International Journal of Radiation Oncology*Biology*Physics

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Functional Data Analysis in NTCP Modeling: A New Method to Explore the Radiation Dose-Volume Effects

Cited by 18 publications

References 21 publications

A Population-based Statistical Model for Investigating Heterogeneous Intraprostatic Sensitivity to Radiation Toxicity After ¹²⁵I Seed Implantation

A Population-based Statistical Model for Investigating Heterogeneous Intraprostatic Sensitivity to Radiation Toxicity After ¹²⁵I Seed Implantation

New Neoadjuvant Treatment Strategies for Non-Metastatic Rectal Cancer (M0)

In Reply to Alber and Söhn

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Functional Data Analysis in NTCP Modeling: A New Method to Explore the Radiation Dose-Volume Effects

Cited by 18 publications

References 21 publications

A Population-based Statistical Model for Investigating Heterogeneous Intraprostatic Sensitivity to Radiation Toxicity After 125I Seed Implantation

A Population-based Statistical Model for Investigating Heterogeneous Intraprostatic Sensitivity to Radiation Toxicity After 125I Seed Implantation

New Neoadjuvant Treatment Strategies for Non-Metastatic Rectal Cancer (M0)

In Reply to Alber and Söhn

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A Population-based Statistical Model for Investigating Heterogeneous Intraprostatic Sensitivity to Radiation Toxicity After ¹²⁵I Seed Implantation

A Population-based Statistical Model for Investigating Heterogeneous Intraprostatic Sensitivity to Radiation Toxicity After ¹²⁵I Seed Implantation