Functional cystic parathyroid adenoma with bilateral mandibular brown tumor: a case report

Al-Smair, Ali; Aloqaily, Mohammed; AlDurgham, Ahmad; AlShatnawi, Mohammad; Saadeh, Ahmad

doi:10.1016/j.radcr.2022.09.036

Cited by 1 publication

(6 citation statements)

References 9 publications

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“…The examination that confirms the diagnosis is the histopathological evaluation of the removed lesion-pathognomonic feature is the presence of parathyroid tissue in the cyst wall [10,[19][20][21].…”

Section: Discussionmentioning

confidence: 92%

“…Most cases, especially those caused by non-functional cysts, are diagnosed incidentally during imaging examination (ultrasound-US, computed tomography-CT, single-photon emission computed tomography-computed tomography-SPECT-CT) [6,10,20,21]. In our patients the US and SPECT-CT were performed.…”

Section: Discussionmentioning

confidence: 95%

“…Cystic parathyroid adenomas are uncommon causes of PHPT (less than 1-2%). In the literature, from 19th century, only less than 400 cases of parathyroid cysts were reported, with the first one described by Sandstrom in 1880 [9,[19][20][21].…”

Section: Discussionmentioning

confidence: 99%

“…Similarly to other endocrine diseases, parathyroid cystic adenomas are encountered more frequently in women with a female-to-male ratio of 2:1 [9,[19][20][21]. In the literature concerning PHPT, the gender ratio oscillates to about 3:1 [2,4].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, another theory suggests that parathyroid cysts can be formed by enlargement or fusion of several parathyroid microcysts. A recurring thesis assumes that initiation of the creation of the functional parathyroid adenomas could be degeneration, hemorrhage or infarction of a parathyroid gland or adenoma [19,20].…”

Section: Discussionmentioning

confidence: 99%

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Cystic Parathyroid Adenomas as a Risk Factor for Severe Hypercalcemia

Kaszczewska

Chudziński

Kaszczewski

et al. 2023

JCM

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(1) Background: Parathyroid cystic adenomas (PCA) are rare entities representing only 0.5–1% of parathyroid adenomas, accounting for 1–2% of cases of primary hyperparathyroidism (PHPT). The purpose of this study was to compare classical and functional/secreting cystic parathyroid lesions and identify risk factors for severe hypercalcemia; (2) Methods: A total of 17 patients with PHPT and parathyroid cysts (study group) were compared with the group of 100 patients with hyperparathyroidism caused by adenoma or hyperplasia (control group). In both groups the majority were women (88% vs. 12%, with gender ratio 7, 3:1). The patients were examined preoperatively and postoperatively: PTH, creatine, calcium and phosphate serum and urine concentrations and calcidiol serum levels were assessed; (3) Results: Patients with parathyroid cyst had statistically higher PTH and calcium serum concentration, higher calciuria and lower serum phosphate concentration. There were no statistically significant differences in the concentration of creatine in serum and urine and tubular reabsorption of phosphorus (TRP); (4) Conclusions: Due to higher PTH and calcium levels, cystic parathyroid adenomas could be one of the rare risk factors for severe hypercalcemia and hypercalcemic crisis which can be life threatening.

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Section: Discussionmentioning

confidence: 92%