Functional crosstalk between chromatin and hypoxia signalling

Collier, Harry R.; Albanese, Adam; Kwok, Chun-Sui; Kou, Jiahua; Rocha, Sónia

doi:10.1016/j.cellsig.2023.110660

Cited by 7 publications

(3 citation statements)

References 127 publications

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“…Here phosphorylation, ubiquitination and sumoylation will be discussed (Fig 4A). Other PTMs such as acetylation are also important, but genome wide research is limited (Collier et al, 2023) and as such will not be described here.…”

Section: Indirect Oxygen-regulated Ptmsmentioning

confidence: 99%

Oxygen‐regulated post‐translation modifications as master signalling pathway in cells

Batie,

Fasanya,

Kenneth

et al. 2023

EMBO Reports

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Oxygen is essential for viability in mammalian organisms. However, cells are often exposed to changes in oxygen availability, due to either increased demand or reduced oxygen supply, herein called hypoxia. To be able to survive and/or adapt to hypoxia, cells activate a variety of signalling cascades resulting in changes to chromatin, gene expression, metabolism and viability. Cellular signalling is often mediated via post‐translational modifications (PTMs), and this is no different in response to hypoxia. Many enzymes require oxygen for their activity and oxygen can directly influence several PTMS. Here, we review the direct impact of changes in oxygen availability on PTMs such as proline, asparagine, histidine and lysine hydroxylation, lysine and arginine methylation and cysteine dioxygenation, with a focus on mammalian systems. In addition, indirect hypoxia‐dependent effects on phosphorylation, ubiquitination and sumoylation will also be discussed. Direct and indirect oxygen‐regulated changes to PTMs are coordinated to achieve the cell's ultimate response to hypoxia. However, specific oxygen sensitivity and the functional relevance of some of the identified PTMs still require significant research.

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Section: Indirect Oxygen-regulated Ptmsmentioning

confidence: 99%

Oxygen‐regulated post‐translation modifications as master signalling pathway in cells

Batie,

Fasanya,

Kenneth

et al. 2023

EMBO Reports

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“…O 2 controls the stability of HIF1A and EPAS1/HIF2A through the action of 2-oxoglutarate (2-OG)-dependent dioxygenases (2-OGDDs) and the prolyl hydroxylases PHD1, PDH2 and PDH3, also known as EGLN2, EGLN1 and EGLN3, respectively (Figure 2). These enzymes hydroxylate key prolines of HIF1A (Pro-402 and Pro-564) and of EPAS1/HIF2A (Pro-405 and Pro-531) using O 2 and α-oxoglutarate [1,12,13]. When HIF1A and EPAS1/HIF2A are hydroxylated, they are recognized by VHL, a tumour suppressor gene responsible for von Hippel-Lindau disease.…”

Section: Introduction the Hypoxia Responsementioning

confidence: 99%

Acetylation and Phosphorylation in the Regulation of Hypoxia-Inducible Factor Activities: Additional Options to Modulate Adaptations to Changes in Oxygen Levels

Minisini,

Cricchi,

Brancolini

2023

Life

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O2 is essential for the life of eukaryotic cells. The ability to sense oxygen availability and initiate a response to adapt the cell to changes in O2 levels is a fundamental achievement of evolution. The key switch for adaptation consists of the transcription factors HIF1A, HIF2A and HIF3A. Their levels are tightly controlled by O2 through the involvement of the oxygen-dependent prolyl hydroxylase domain-containing enzymes (PHDs/EGNLs), the von Hippel–Lindau tumour suppressor protein (pVHL) and the ubiquitin–proteasome system. Furthermore, HIF1A and HIF2A are also under the control of additional post-translational modifications (PTMs) that positively or negatively regulate the activities of these transcription factors. This review focuses mainly on two PTMs of HIF1A and HIF2A: phosphorylation and acetylation.

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“…Some of the downstream genes can regulate the erythropoietic response, including those encoding endogenous EPO, enzymes involved in heme biosynthesis, and proteins that promote the availability of bone marrow iron. 13 , 14 , 15 Roxadustat is an HIF-PH inhibitor approved by the regulatory agency to treat anemia in patients with CKD in Europe, China, and Japan, but has not been approved in the United States to date. 16 Roxadustat significantly increased and maintained Hb levels in various randomized controlled studies in different cohorts, including nondialysis patients, patients on hemodialysis, and patients on peritoneal dialysis.…”

mentioning

confidence: 99%

The Efficacy and Safety of Roxadustat for the Treatment of Posttransplantation Anemia: A Randomized Study

Kong,

Wu,

Shen

et al. 2024

Kidney International Reports

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Functional crosstalk between chromatin and hypoxia signalling

Cited by 7 publications

References 127 publications

Oxygen‐regulated post‐translation modifications as master signalling pathway in cells

Oxygen‐regulated post‐translation modifications as master signalling pathway in cells

Acetylation and Phosphorylation in the Regulation of Hypoxia-Inducible Factor Activities: Additional Options to Modulate Adaptations to Changes in Oxygen Levels

The Efficacy and Safety of Roxadustat for the Treatment of Posttransplantation Anemia: A Randomized Study

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