Functional coupling of simultaneous electrical and metabolic activity in the human brain

Oakes, Terrence R.; Pizzagalli, Diego A.; Hendrick, Andrew; Horras, Katherine A.; Larson, Christine L.; Abercrombie, Heather C.; Schaefer, Stacey M.; Koger, John; Davidson, Richard J.

doi:10.1002/hbm.20004

Cited by 197 publications

(174 citation statements)

References 70 publications

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“…3b). We know that increased beta power is associated with increased metabolic activity as seen by PET (Oakes et al, 2004). Our case shows a correlation between increased beta power (qEEG) and increased perfusion (SPECT).…”

Section: Resultssupporting

confidence: 59%

Compulsive Hoarding in an Older Adult with Aggression, Delusions and Memory Loss: A Multimodality Neuroimaging Study

et al. 2009

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Multimodal assessment practices offer enriching contributions to linkages between clinical presentation and brain presentation. The following case study is an illustration of the effectiveness of structural and functional imaging in the diagnosis process. In this article a clinical vignette is given in which the client (Mr. B) presents with aggressive behavior, delusions, memory complaints and hoarding behaviors. The findings of the case of presented based on multimodal structural and functional imaging. Mr. B was evaluated using MRI (magnetic resonance imaging), EEG (electroencephalography), qEEG (quantitative EEG), LORETA (low resolution electromagnetic tomography), SPECT (single photon emission computed tomography), quantitative SPECT and neuropsychological testing. Visual analysis of EEG recording revealed sharp waves with reversals primarily in the mid-central region (Cz). Quantitative analysis of background activity acquired in eyes closed and alert state revealed increased absolute and relative beta power maximally distributed to the mid-central region (Cz). This was consistent with the source analysis obtained from LORETA. Visual inspection of SPECT data indicated increased blood perfusion in the posterior cingulate cortex. The quantitative analysis of SPECT images, on the contrary revealed decreased perfusion in both anterior and posterior cingulate cortex. Furthermore, increased perfusion in bilateral sensori-motor cortices (right more than left) and decreased perfusion in the left posterior temporal lobe was observed. T-1 based MRI of the brain showed generalized cerebral atrophy. On neuropsychological testing Mr. B was able to complete only tests of lesser complexity. Base on published data Mr. B's structural and functional imaging can be linked to his clinical presentation and a potential diagnosis of Frontal Temporal lobe Disorder (FTD). The use of multimodalities and objective analysis of data can lead to more accurate case conceptualizations and linkages between brain structure/functionality and clinical presentation.

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Section: Resultssupporting

confidence: 59%

Compulsive Hoarding in an Older Adult with Aggression, Delusions and Memory Loss: A Multimodality Neuroimaging Study

et al. 2009

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“…By simultaneously measuring EEG and PET/fMRI, sensorimotor alpha and mu-band suppression has been associated with increased cerebral activity (Goldman et al, 2002;Oakes et al, 2004). Furthermore, mu-band suppression has been linked to sensorimotor processing (Pineda, 2005), such as action execution and observation (Gastaut, 1952), tactile stimulation (Pfurtscheller, 1981), and observed tactile stimulation of others (Cheyne et al, 2003).…”

Section: Electrophysiology Of Ownershipmentioning

confidence: 99%

Shared electrophysiology mechanisms of body ownership and motor imagery

Evans

Blanke

2013

NeuroImage

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Although we feel, see, and experience our hands as our own (body or hand ownership), recent research has shown that illusory hand ownership can be induced for fake or virtual hands and may be useful for neuroprosthetics and brain-computer interfaces. Despite the vast amount of behavioral data on illusory hand ownership, neuroimaging studies are rare, in particular electrophysiological studies. Thus, while the neural systems underlying hand ownership are relatively well described, the spectral signatures of body ownership as measured by electroencephalography (EEG) remain elusive. Here we induced illusory hand ownership in an automated, computer-controlled manner using virtual reality while recording 64-channel EEG and found that illusory hand ownership is reflected by a body-specific modulation in the mu-band over fronto-parietal cortex. In a second experiment in the same subjects, we then show that mu as well as beta-band activity in highly similar fronto-parietal regions was also modulated during a motor imagery task often used in paradigms employing non-invasive brain-computer interface technology. These data provide insights into the electrophysiological brain mechanisms of illusory hand ownership and their strongly overlapping mechanisms with motor imagery in fronto-parietal cortex. They also highlight the potential of combining high-resolution EEG with virtual reality setups and automatized stimulation protocols for systematic, reproducible stimulus presentation in cognitive neuroscience, and may inform the design of non-invasive brain-computer interfaces.

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“…One method of measuring energetic state is through the analysis of rhythmic oscillations in the ongoing EEG. Research focused on oscillations in the alpha band (8-13Hz) has revealed an inverse relationship between alpha power and cortical arousal (Oakes et al, 2004;Shagass, 1972). More recently it has been found that alpha in the prestimulus period varies as a function of the energetic requirements of a task (Carp and Compton, 2009;Klimesch et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Event-rate effects in the flanker task: ERPs and task performance in children with and without AD/HD

Johnstone

Galletta

2013

International Journal of Psychophysiology

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Demanding tasks require a greater amount of effort, in which case individuals are required to alter their energetic-state to a level appropriate to perform the task. According to the Cognitive-Energetic Model (CEM), children with AD/HD are unable to effectively modulate their energetic state, leading to task underperformance. Using an Eriksen flanker task with varying event-rates, the current study compared the ability of typically-developing children and children with AD/HD to modulate their energetic state. In line with the CEM, it was predicted that children with AD/HD would underperform in the fast and slow eventrates. Results indicated that the groups did not differ in commission errors (i.e., incorrect responses). However, children with AD/HD made more omission errors to incongruent stimuli at the fast and slow eventrates, compared to controls. N2 amplitude was significantly larger for the AD/HD than control group in the slow event-rate. It is concluded that the energetic state modulation dysfunction in children with AD/HD results in an inability to attend to the task, as opposed to an inability to perform the task itself. Furthermore, these task performance differences did not manifest in either the N2 or P3 ERP components. Therefore, inattention in children with AD/HD may have its locus in response preparation, as opposed to stimulus processing, but more research is required to validate these conjectures. Abstract: Demanding tasks require a greater amount of effort, in which case individuals are required to alter their energetic-state to a level appropriate to perform the task. According to the CognitiveEnergetic Model (CEM), children with AD/HD are unable to effectively modulate their energetic state, leading to task underperformance. Using an Eriksen flanker task with varying event-rates, the current study compared the ability of typically-developing children and children with AD/HD to modulate their energetic state. In line with the CEM, it was predicted that children with AD/HD would underperform in the fast and slow event-rates. Results indicated that the groups did not differ in commission errors (i.e., incorrect responses). However, children with AD/HD made more omission errors (i.e., impulsively early or non-responses) to incongruent stimuli at the fast and slow event-rates, compared to controls. N2 amplitude was significantly larger for the AD/HD than control group in the slow event-rate. It is concluded that the energetic state modulation dysfunction in children with AD/HD results in an inability to attend to the task, as opposed to an inability to perform the task itself. Furthermore, these task performance differences did not manifest in either the N2 or P3 ERP components. Therefore, inattention in children with AD/HD may have its locus in response preparation, as opposed to stimulus processing, but more research is required to validate these conjectures. Highlights Children with AD/HD unable to effectively modulate energetic state  Event-rate varied during interference control in c...

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Functional coupling of simultaneous electrical and metabolic activity in the human brain

Cited by 197 publications

References 70 publications

Compulsive Hoarding in an Older Adult with Aggression, Delusions and Memory Loss: A Multimodality Neuroimaging Study

Compulsive Hoarding in an Older Adult with Aggression, Delusions and Memory Loss: A Multimodality Neuroimaging Study

Shared electrophysiology mechanisms of body ownership and motor imagery

Event-rate effects in the flanker task: ERPs and task performance in children with and without AD/HD

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