Functional coupling between CA3 and laterobasal amygdala supports schema dependent memory formation

Yousuf, Mushfa; Packard, Pau A.; Fuentemilla, Lluís; Bunzeck, Nico

doi:10.1016/j.neuroimage.2021.118563

Cited by 10 publications

(5 citation statements)

References 76 publications

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“…This is, again, in line with individual studies that drive the effect (Hall et al, 2008; Kim et al, 2011) and others that also show early structural degenerations within the amygdala (Planche et al, 2022; Poulin et al, 2011; Ramos Bernardes da Silva Filho et al, 2017). From an anatomical point of view, the amygdala represents a central target region of NbM projections, including a high density of cholinergic axons (Mesulam and Geula, 1988; Mesulam et al, 1992), and functionally it is prominent for its role in processing emotional information (Dolan, 2002; LeDoux, 2003) but also memory formation and consolidation (Rutishauser et al, 2010; Yousuf et al, 2021). For instance, cholinergic stimulation in healthy middle aged humans reduced activity in the right amygdala for successful versus unsuccessful spatial context retrieval (Kukolja et al, 2009), which is in line with others suggesting that high levels of ACh promote encoding but interfere with retrieval (Winters et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Structural Degeneration of the Nucleus basalis of Meynert in Mild Cognitive Impairment and Alzheimer’s Disease – Evidence from an MRI-based Meta-Analysis

Mieling,

Meier,

Bunzeck

2023

Preprint

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Recent models of Alzheimer's Disease (AD) suggest that neuropathological changes of the medial temporal lobe, especially entorhinal cortex, are preceded by degenerations of the cholinergic Nucleus basalis of Meynert (NbM). Evidence from imaging studies in humans, however, is limited. Therefore, we performed an activation-likelihood estimation meta-analysis on whole brain voxel-based morphometry (VBM) MRI data from 54 experiments and 2581 subjects in total. It revealed, compared to healthy older controls, reduced gray matter in the bilateral NbM in AD, but only limited evidence for such an effect in patients with mild cognitive impairment (MCI), which typically precedes AD. Both patient groups showed less gray matter in the amygdala and hippocampus, with hints towards more pronounced amygdala effects in AD. We discuss our findings in the context of studies that highlight the importance of the cholinergic basal forebrain in learning and memory throughout the life span, and conclude that they are partly compatible with pathological staging models suggesting initial and pronounced structural degenerations within the NbM in the progression of AD.

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Section: Discussionmentioning

confidence: 99%

Structural Degeneration of the Nucleus basalis of Meynert in Mild Cognitive Impairment and Alzheimer’s Disease – Evidence from an MRI-based Meta-Analysis

Mieling,

Meier,

Bunzeck

2023

Preprint

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“…The amygdala responds to novelty as well [71,72] and amygdala activity during encoding has been linked to later memory success [73]. One study in younger and older human adults found a functional link between the amygdala and hippocampal region CA3 specifically for memory for semantically congruent events [74], suggesting that the amygdala may play a modulating role in schema-dependent memory. Through its interconnections with the hippocampus, the amygdala is also activated in response to the prediction error generated by schema-incongruent information in the hippocampus and the need to update the emotional value of the new stimuli or information that is inconsistent with prior knowledge or associations [29,75,76].…”

Section: How Does the Brain 'Decide' Whether To Update The Schema Or ...mentioning

confidence: 99%

To update or to create? The influence of novelty and prior knowledge on memory networks

Sekeres,

Schomaker,

Nadel

et al. 2024

Phil. Trans. R. Soc. B

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Schemas are foundational mental structures shaped by experience. They influence behaviour, guide the encoding of new memories and are shaped by associated information. The adaptability of memory schemas facilitates the integration of new information that aligns with existing knowledge structures. First, we discuss how novel information consistent with an existing schema can be swiftly assimilated when presented. This cognitive updating is facilitated by the interaction between the hippocampus and the prefrontal cortex. Second, when novel information is inconsistent with the schema, it likely engages the hippocampus to encode the information as part of an episodic memory trace. Third, novelty may enhance hippocampal dopamine through either the locus coeruleus or ventral tegmental area pathways, with the pathway involved potentially depending on the type of novelty encountered. We propose a gradient theory of schema and novelty to elucidate the neural processes by which schema updating or novel memory traces are formed. It is likely that experiences vary along a familiarity–novelty continuum, and the degree to which new experiences are increasingly novel will guide whether memory for a new experience either integrates into an existing schema or prompts the creation of a new cognitive framework. This article is part of the theme issue ‘Long-term potentiation: 50 years on’.

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“…It is conceivable that pattern completion is implicated in knowledge-related new memories. Although human studies are scarce, a notable study by Yousuf, Packard, Fuentemilla, and Bunzeck (2021) showed converging evidence with enhanced activation of CA3 for successful encoding of items with semantically congruent cues. Importantly, in development, the earlier maturation of CA1 may underlie the bias toward generalization in early childhood.…”

Section: Prior Knowledge and Memory At Infancymentioning

confidence: 99%

Are there Age‐Related Differences in the Effects of Prior Knowledge on Learning? Insights Gained from the Memory Congruency Effect

Brod

Shing

2022

Mind Brain and Education

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Humans accumulate knowledge throughout their entire lives. In what ways does this accumulation of knowledge influence learning of new information? Are there age-related differences in the way prior knowledge is leveraged for remembering new information? We review studies that have investigated these questions, focusing on those that have used the memory congruency effect, which provides a quantitative measure of memory advantage because of prior knowledge. Regarding the first question, evidence suggests that the accumulation of knowledge is a key factor promoting the development of memory across childhood and counteracting some of the decline in older age. Regarding the second question, evidence suggests that, if available knowledge is controlled for, age-related differences in the memory congruency effect largely disappear. These results point to an age-invariance in the way prior knowledge is leveraged for learning new information. Research on neural mechanisms and implications for application are discussed.Memory performance improves substantially during the first two decades of life (Schneider, 2015). It has long been

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Functional coupling between CA3 and laterobasal amygdala supports schema dependent memory formation

Cited by 10 publications

References 76 publications

Structural Degeneration of the Nucleus basalis of Meynert in Mild Cognitive Impairment and Alzheimer’s Disease – Evidence from an MRI-based Meta-Analysis

Structural Degeneration of the Nucleus basalis of Meynert in Mild Cognitive Impairment and Alzheimer’s Disease – Evidence from an MRI-based Meta-Analysis

To update or to create? The influence of novelty and prior knowledge on memory networks

Are there Age‐Related Differences in the Effects of Prior Knowledge on Learning? Insights Gained from the Memory Congruency Effect

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