Functional Correlations of Tympanic Membrane Perforation Size

Lerut, Bob; Pfammatter, Alain; Moons, Johnny; Linder, Thomas

doi:10.1097/mao.0b013e318245cea5

Cited by 52 publications

(48 citation statements)

References 19 publications

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“…Below 2000 Hz, the ABG is larger for the lower frequencies, and above 2000 Hz, the ABG gets bigger again in the higher frequencies. These observations are similar to those made by Lerut et al [18] As the inherent frequency of the TM has been calculated to be at 2000 Hz, that is, the TM vibrates the most at 2000 Hz, the least loss of sound transmission (or best hearing) has been observed around 2000 Hz.…”

Section: Hearing Loss Irrespective Of Site and Size Of Perforationsupporting

confidence: 82%

Tympanic membrane perforation: Its correlation with hearing loss and frequency affected - An analytical study

Nahata

Patil

et al. 2014

Indian J Otol

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Section: Hearing Loss Irrespective Of Site and Size Of Perforationsupporting

confidence: 82%

Tympanic membrane perforation: Its correlation with hearing loss and frequency affected - An analytical study

Nahata

Patil

et al. 2014

Indian J Otol

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“…The perforations always occurred within the inferior aspect of the tympanic membrane. The size of every perforation was estimated visually by the same observer using a well-validated technique used in the clinic to assess patients with tympanic membrane perforations [18], [19], [20]. With this technique, the perforation is compared against a model where the tympanic membrane is divided into four equal sections defined by two lines, one along and one perpendicular to the malleus ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Mechanisms of Hearing Loss after Blast Injury to the Ear

et al. 2013

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Given the frequent use of improvised explosive devices (IEDs) around the world, the study of traumatic blast injuries is of increasing interest. The ear is the most common organ affected by blast injury because it is the body’s most sensitive pressure transducer. We fabricated a blast chamber to re-create blast profiles similar to that of IEDs and used it to develop a reproducible mouse model to study blast-induced hearing loss. The tympanic membrane was perforated in all mice after blast exposure and found to heal spontaneously. Micro-computed tomography demonstrated no evidence for middle ear or otic capsule injuries; however, the healed tympanic membrane was thickened. Auditory brainstem response and distortion product otoacoustic emission threshold shifts were found to be correlated with blast intensity. As well, these threshold shifts were larger than those found in control mice that underwent surgical perforation of their tympanic membranes, indicating cochlear trauma. Histological studies one week and three months after the blast demonstrated no disruption or damage to the intra-cochlear membranes. However, there was loss of outer hair cells (OHCs) within the basal turn of the cochlea and decreased spiral ganglion neurons (SGNs) and afferent nerve synapses. Using our mouse model that recapitulates human IED exposure, our results identify that the mechanisms underlying blast-induced hearing loss does not include gross membranous rupture as is commonly believed. Instead, there is both OHC and SGN loss that produce auditory dysfunction.

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“…The effect of tympanic membrane (TM) perforation has been studied extensively (Lerut et al 2012; Mehta et al 2006; Voss et al 2001a, 2001b, 2001c). Transduction of sound from the ear canal towards the cochlea has been shown to decrease with the increase in perforation size at lower frequencies, while the location of the perforation does not affect the transduction.…”

Section: Disease Affecting the Tympanic Membranementioning

confidence: 99%

Assessment of Ear Disorders Using Power Reflectance

et al. 2013

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This paper describes the effect of various pathologies on power reflectance (PR) and absorbance measured in human adults. The pathologies studied include those affecting the tympanic membrane, the middle-ear ossicles, the middle-ear cavity, the inner ear, and intracranial pressure. Interesting pathology-induced changes in PR that are statistically significant have been reported. Nevertheless, because measurements of PR obtained from normal-hearing subjects have large variations and some pathology-induced changes are small, it can be difficult to use PR alone for differential diagnosis. There are, however, common clinical situations without reliable diagnostic methods that can benefit from PR measurements. These conditions include ears with a normal-appearing tympanic membrane, aerated middle-ear cavity and unknown etiology of conductive hearing loss. PR measurements in conjunction with audiometric measurements of air-bone gap have promise in differentiating among stapes fixation, ossicular discontinuity and superior semicircular canal dehiscence. Another possible application is to monitor an individual for possible changes in intracranial pressure. Descriptions of mechanisms affecting PR change and utilization of PR measurements in clinical scenarios are presented.

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Functional Correlations of Tympanic Membrane Perforation Size

Cited by 52 publications

References 19 publications

Tympanic membrane perforation: Its correlation with hearing loss and frequency affected - An analytical study

Tympanic membrane perforation: Its correlation with hearing loss and frequency affected - An analytical study

Mechanisms of Hearing Loss after Blast Injury to the Ear

Assessment of Ear Disorders Using Power Reflectance

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