Functional connectivity in category‐selective brain networks after encoding predicts subsequent memory

Abstract

Activity in category selective regions of the temporal and parietal lobes during encoding has been associated with subsequent memory for face and scene stimuli. Reactivation theories of memory consolidation predict that after encoding connectivity between these category-selective regions and the hippocampus should be modulated and predict recognition memory. However, support for this proposal has been limited in humans. Here, participants completed a resting-state functional MRI (fMRI) scan, followed by face- and place-encoding tasks, followed by another resting-state fMRI scan during which they were asked to think about the stimuli they had previously encountered. Individual differences in face recognition memory were predicted by the degree to which connectivity between face-responsive regions of the fusiform gyrus and perirhinal cortex increased following the face-encoding task. In contrast, individual differences in scene recognition were predicted by connectivity between the hippocampus and a scene-selective region of the retrosplenial cortex before and after the place-encoding task. Our results provide novel evidence for category specificity in the neural mechanisms supporting memory consolidation.

Mapping of impaired functional connectivity during memory phases in Alzheimer's disease and its association with cortical β-amyloid

“…2). The pattern of Network 1 is like the joint of the anteriortemporal and posterior-medial system (30), which work interactively for encoding and retrieval memory (31,32). The reduced functional connectivity within Network 1 is consistent with evidence found in resting-state fMRI, both in AD and cognitively unimpaired amyloid-β + individuals (22,33).…”

Sleep Spindles Promote the Restructuring of Memory Representations in Ventromedial Prefrontal Cortex through Enhanced Hippocampal–Cortical Functional Connectivity

“…A prior study measuring simultaneous EEG-fMRI during sleep reported that fast spindle amplitude modulated univariate activation selectively in brain regions activated during the preceding encoding task (Bergmann et al, 2012). Likewise, reports have shown experience-dependent changes in postencoding hippocampal functional connectivity with cortical regions previously engaged during encoding (Tambini et al, 2010;van Kesteren et al, 2010;Vilberg and Davachi, 2013;Schlichting and Preston, 2014;Murty et al, 2017;Collins and Dickerson, 2019). Here, in line with the proposed dichotomy in anterior and posterior hippocampal networks and functional specialization (Davachi, 2006;Libby et al, 2012;Ranganath and Ritchey, 2012;Poppenk et al, 2013;Robin and Moscovitch, 2017), we found that fast spindle density correlated with next-day anterior hippocampal-vmPFC and posterior hippocampal-PMC functional connectivity for the object-word and scene-word pairs, respectively.…”

Altered functional connectivity of cortical networks in semantic variant Primary Progressive Aphasia

“…That is, the caudal visual association occipitotemporal cortical nodes are weakly linked to the dorsal attention network and anticorrelated with the default mode network, while the rostral ventral temporal extension of the visual association cortex is weakly connected to the default mode network. The PRC is a key node of the anterior default mode network and plays an important role in memory, especially familiarity-based item recognition memory (Collins & Dickerson, 2019;Dickerson & Eichenbaum, 2010;La Joie et al, 2014;Ranganath & Ritchey, 2012;Suzuki & Naya, 2014). The PRC has also been postulated to be the apex of the visual association network (Collins & Olson, 2014), responsible for linking complex visual representations to their associated semantic features (Barbeau et al, 2008;Martin et al, 2013;Taylor et al, 2006).…”