Functional connectivity in behavioral variant frontotemporal dementia

Ferreira, Luiz Kobuti; Lindberg, Olof; Santillo, Alexander; Wahlund, Lars‐Olof

doi:10.1002/brb3.2790

Cited by 6 publications

(4 citation statements)

References 161 publications

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“…On the one hand, indirect evidence suggests that the proposed preference for less abstract concepts in PD may not be mirrored in this disease 4 , 44 . On the other, semantic variability may be similarly altered in bvFTD, which also involves marked inhibitory deficits 45 and disruptions of key correlates, such as the salience network 46 . More generally, while lexico-semantic deficits are pervasive in PD 2 , 47 , they emerge less consistently in bvFTD 43 , 48 , likely supporting individual patient identification in the former but not in the latter population.…”

Section: Introductionmentioning

confidence: 99%

Neurocognitive correlates of semantic memory navigation in Parkinson’s disease

Toro-Hernández,

Migeot,

Marchant

et al. 2024

npj Parkinsons Dis.

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Cognitive studies on Parkinson’s disease (PD) reveal abnormal semantic processing. Most research, however, fails to indicate which conceptual properties are most affected and capture patients’ neurocognitive profiles. Here, we asked persons with PD, healthy controls, and individuals with behavioral variant frontotemporal dementia (bvFTD, as a disease control group) to read concepts (e.g., ‘sun’) and list their features (e.g., hot). Responses were analyzed in terms of ten word properties (including concreteness, imageability, and semantic variability), used for group-level comparisons, subject-level classification, and brain-behavior correlations. PD (but not bvFTD) patients produced more concrete and imageable words than controls, both patterns being associated with overall cognitive status. PD and bvFTD patients showed reduced semantic variability, an anomaly which predicted semantic inhibition outcomes. Word-property patterns robustly classified PD (but not bvFTD) patients and correlated with disease-specific hypoconnectivity along the sensorimotor and salience networks. Fine-grained semantic assessments, then, can reveal distinct neurocognitive signatures of PD.

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Section: Introductionmentioning

confidence: 99%

Neurocognitive correlates of semantic memory navigation in Parkinson’s disease

Toro-Hernández,

Migeot,

Marchant

et al. 2024

npj Parkinsons Dis.

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“…20 However, we did not observe a stronger correlation between the seed in the posterior cingulate cortex and other parts of the DMN in patients than in controls, which is in line with a recent review that found inconsistent evidence for this hypothesise. 18…”

Section: Discussionmentioning

confidence: 99%

“…13,14 Whilst there is heterogeneity in the pattern of atrophy and heterogeneity in respect to underlying neuropathology of bvFTD, studies have demonstrated a consistent core of neurodegeneration involving the AI and ACC across all cases of bvFTD. 15,16 This characteristic pattern of neurodegeneration is further reflected in reduced functional connectivity of the AI and ACC, which may be identified using resting state functional MRI 17,18 . The AI and the ACC (its posterior part, sometimes referred to as midcingulate cortex, MCC) have been shown to be central nodes in the ventral attention network (VAN), 19 also referred to as the “salience network”.…”

Section: Introductionmentioning

confidence: 99%

Altered empathy processing in frontotemporal dementia A task-based fMRI study

Lindberg,

Li,

Lind

et al. 2024

Preprint

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A lack of empathy, and particularly its affective components, is a core symptom of behavioural variant frontotemporal dementia (bvFTD). Visual exposure to images of a needle pricking a hand (pain condition) and Q-tips touching a hand (control condition) is an established functional magnetic resonance imaging (fMRI) paradigm used to investigate empathy for pain (EFP; pain condition minus control condition). EFP has been associated with increased blood oxygen level dependent (BOLD) signal in regions known to become atrophic in the early stages in bvFTD, including the anterior insula and the anterior cingulate. We therefore hypothesized that patients with bvFTD would display altered empathy processing in the EFP paradigm. Here we examined empathy processing using the EFP paradigm in 28 patients with bvFTD and 28 sex and age matched controls. Participants underwent structural MRI, task-based and resting-state fMRI. The Interpersonal Reactivity Index (IRI) was used as a measure of different facets of empathic function outside the scanner. The EFP paradigm was analysed at a whole brain level and using two regions-of-interest approaches, one based on a metanalysis of affective perceptual empathy versus cognitive evaluative empathy and one based on the control's activation pattern. In controls, EFP was linked to an expected increase of BOLD signal that displayed an overlap with the pattern of atrophy in the bvFTD patients (insula and anterior cingulate). Additional regions with increased signal were the supramarginal gyrus and the occipital cortex. These latter regions were the only ones that displayed increased BOLD signal in bvFTD patients. BOLD signal increase under the affective perceptual empathy but not the cognitive evaluative empathy region of interest was significantly greater in controls than in bvFTD patients. The control's rating on their empathic concern subscale of the IRI was significantly correlated with the BOLD signal in the EFP paradigm, as were an informant's ratings of the patient's empathic concern subscale. This correlation was not observed on other subscales of the IRI or when using the patient's self-ratings. Finally, controls and patients showed different connectivity patterns in empathy related networks during resting-state fMRI, mainly in nodes overlapping the ventral attention network. Our results indicate that reduced neural activity in regions typically affected by pathology in bvFTD is associated with reduced empathy processing, and a predictor of patient's capacity to experience affective empathy.

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“…Functional changes were studied using resting-state functional magnetic resonance imaging (rsfMRI), providing measures of spontaneous brain activity and functional connectivity (FC) (Azeez & Biswal, 2017 ). Decreased FC in bvFTD was reported within/between lateral prefrontal, basal ganglia, insular, hippocampal and amygdalar regions as well as salience and default mode networks (Ferreira et al, 2022 ; Kamalian et al, 2022 ). Conversely, increased FC was reported within the default mode network (Filippi et al, 2013 ; Whitwell et al, 2011 ).…”

Section: Introductionmentioning

confidence: 99%

Fronto-striatal alterations correlate with apathy severity in behavioral variant frontotemporal dementia

Upadhyay,

Spottke,

Schneider

et al. 2023

Brain Imaging and Behavior

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Structural and functional changes in cortical and subcortical regions have been reported in behavioral variant frontotemporal dementia (bvFTD), however, a multimodal approach may provide deeper insights into the neural correlates of neuropsychiatric symptoms. In this multicenter study, we measured cortical thickness (CTh) and subcortical volumes to identify structural abnormalities in 37 bvFTD patients, and 37 age- and sex-matched healthy controls. For seed regions with significant structural changes, whole-brain functional connectivity (FC) was examined in a sub-cohort of N = 22 bvFTD and N = 22 matched control subjects to detect complementary alterations in brain network organization. To explore the functional significance of the observed structural and functional deviations, correlations with clinical and neuropsychological outcomes were tested where available. Significantly decreased CTh was observed in the bvFTD group in caudal middle frontal gyrus, left pars opercularis, bilateral superior frontal and bilateral middle temporal gyrus along with subcortical volume reductions in bilateral basal ganglia, thalamus, hippocampus, and amygdala. Resting-state functional magnetic resonance imaging showed decreased FC in bvFTD between: dorsal striatum and left caudal middle frontal gyrus; putamen and fronto-parietal regions; pallidum and cerebellum. Conversely, bvFTD showed increased FC between: left middle temporal gyrus and paracingulate gyrus; caudate nucleus and insula; amygdala and parahippocampal gyrus. Additionally, cortical thickness in caudal, lateral and superior frontal regions as well as caudate nucleus volume correlated negatively with apathy severity scores of the Neuropsychiatry Inventory Questionnaire. In conclusion, multimodal structural and functional imaging indicates that fronto-striatal regions have a considerable influence on the severity of apathy in bvFTD.

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Functional connectivity in behavioral variant frontotemporal dementia

Cited by 6 publications

References 161 publications

Neurocognitive correlates of semantic memory navigation in Parkinson’s disease

Neurocognitive correlates of semantic memory navigation in Parkinson’s disease

Altered empathy processing in frontotemporal dementia A task-based fMRI study

Fronto-striatal alterations correlate with apathy severity in behavioral variant frontotemporal dementia

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