Functional connectivity homogeneity correlates with duration of temporal lobe epilepsy

Haneef, Zulfi; Chiang, Sharon; Yeh, Hsiang J.; Engel, Jerome; Stern, John M.

doi:10.1016/j.yebeh.2015.01.025

Cited by 28 publications

(26 citation statements)

References 46 publications

(62 reference statements)

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“…Differences on connectivity alterations between left and right MTLE have been previously described in the literature [Haneef et al, 2015;Pereira et al, 2010;Waites et al, 2006]. Through diversified methodologies, these studies explored distinct aspects of brain functional connectivity using anatomical or functional relevant ROIs, independent component analysis and graph theoretical information.…”

Section: Discussionmentioning

confidence: 97%

Large‐scale brain networks are distinctly affected in right and left mesial temporal lobe epilepsy

Campos

Coan

Yasuda

et al. 2016

Human Brain Mapping

109

102

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Mesial temporal lobe epilepsy (MTLE) with hippocampus sclerosis (HS) is associated with functional and structural alterations extending beyond the temporal regions and abnormal pattern of brain resting state networks (RSNs) connectivity. We hypothesized that the interaction of large‐scale RSNs is differently affected in patients with right‐ and left‐MTLE with HS compared to controls. We aimed to determine and characterize these alterations through the analysis of 12 RSNs, functionally parceled in 70 regions of interest (ROIs), from resting‐state functional‐MRIs of 99 subjects (52 controls, 26 right‐ and 21 left‐MTLE patients with HS). Image preprocessing and statistical analysis were performed using UF2C‐toolbox, which provided ROI‐wise results for intranetwork and internetwork connectivity. Intranetwork abnormalities were observed in the dorsal default mode network (DMN) in both groups of patients and in the posterior salience network in right‐MTLE. Both groups showed abnormal correlation between the dorsal‐DMN and the posterior salience, as well as between the dorsal‐DMN and the executive‐control network. Patients with left‐MTLE also showed reduced correlation between the dorsal‐DMN and visuospatial network and increased correlation between bilateral thalamus and the posterior salience network. The ipsilateral hippocampus stood out as a central area of abnormalities. Alterations on left‐MTLE expressed a low cluster coefficient, whereas the altered connections on right‐MTLE showed low cluster coefficient in the DMN but high in the posterior salience regions. Both right‐ and left‐MTLE patients with HS have widespread abnormal interactions of large‐scale brain networks; however, all parameters evaluated indicate that left‐MTLE has a more intricate bihemispheric dysfunction compared to right‐MTLE. Hum Brain Mapp 37:3137–3152, 2016. © 2016 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 97%

Large‐scale brain networks are distinctly affected in right and left mesial temporal lobe epilepsy

Campos

Coan

Yasuda

et al. 2016

Human Brain Mapping

109

102

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“…Examining both functional and volumetric MRI measures, Morgan et al noted progressively diminished connectivity in the temporal lobe, precuneus, and cingulate—as well as hippocampal and pallidal volume loss—over time in MTLE patients. Furthermore, using graph theory analysis, Haneef et al noted global decreases in resting fMRI connectivity in MTLE, along with a progressive reduction in connectivity diversity over time. Several other investigations have also demonstrated positive relationships between disease severity and/or duration with intrinsic connectivity aberrations in various networks of both MTLE and FNE patients.…”

Section: Global Connectivity Alterationsmentioning

confidence: 99%

“…Examining both functional and volumetric MRI measures, Morgan et al 54 noted progressively diminished connectivity in the temporal lobe, precuneus, and cingulate -as well as hippocampal and pallidal volume loss-over time in MTLE patients. Furthermore, using graph theory analysis, Haneef et al 55 compared to controls, overlaid on a 3D-rendered template brain. FDR, false discovery rate; FNE, focal neocortical epilepsy; MTLE, mesial temporal lobe epilepsy.…”

Section: Global Connectivity Alterationsmentioning

confidence: 99%

Regional and global connectivity disturbances in focal epilepsy, related neurocognitive sequelae, and potential mechanistic underpinnings

2016

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Epilepsy is among the most common brain network disorders, and it is associated with substantial morbidity and increased mortality. While focal epilepsy was traditionally thought of as a regional brain disorder, growing evidence has demonstrated widespread network alterations in this disorder which extend beyond the epileptogenic zone from which seizures originate. The goal of this review is to summarize recent investigations examining functional and structural connectivity alterations in focal epilepsy, including neuroimaging and electrophysiology studies utilizing model-based or data-driven analysis methods. A significant subset of studies in both mesial temporal lobe epilepsy and focal neocortical epilepsy have demonstrated patterns of increased connectivity related to the epileptogenic zone, coupled with decreased connectivity in widespread distal networks. Connectivity patterns appear to be related to the duration and severity of disease, suggesting progressive connectivity reorganization in the setting of recurrent seizures over time. Global resting-state connectivity disturbances in focal epilepsy have been linked to neurocognitive problems, including memory and language disturbances. While it is possible that increased connectivity in a particular brain region may enhance the propensity for seizure generation, it is not clear if global reductions in connectivity represent the damaging consequences of recurrent seizures, or an adaptive mechanism to prevent seizure propagation away from the epileptogenic zone. Overall, studying the connectome in focal epilepsy is a critical endeavor which may lead to improved strategies for epileptogenic zone localization, surgical outcome prediction, and a better understanding of the neuropsychological implications of recurrent seizures.

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“…In several studies, decreased functional connectivity was observed in the ipsilateral hemisphere while increases were found in contralateral mesiotemporal networks [14,15]. However, in some other studies, functional connectivity analysis showed that functional connectivity between epileptic focus and ipsilateral hemisphere increased during interictal period ,involving hypothalamus, temporal lobe, insula, frontal lobe, basal ganglia, angular gyrus, cerebellum and brainstem [16,17]. Kucukboyaci et al [18] reported extensive regional FC reductions during the interictal period, including reductions in the ipsilateral hippocampus and parahippocampal gyrus, which can be found in both sides, but more prominent in the epileptic side.…”

Section: Reviewmentioning

confidence: 98%

Abnormal Brain Network in Epilepsy and Associated Comorbidites

Yang¹,

Ren²,

Wang³

2018

Neuropsychiatry

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Epilepsy has been recognized as a brain network disorder. With the development of techniques investigating structural and functional brain network, current studies provided insights into the physiopathogenesis of the epilepsy, including focal epilepsy and idiopathic generalized epilepsy. Besides, a number of studies have shed light on the effects of epilepsy on other functional networks, which help to explain cognitive impairment and psychiatric disorders comorbid with epilepsy. In this review, we will discuss current studies that provide structural and functional network evidence of epilepsy or its cognitive and psychiatric comorbidities. Clinical features and outcome of epilepsy result from changes in the networks, which are associated with the clinical course of the disease, the presence of complications and the location of the epileptogenic zone. Different network changes and remodeling are closely related to the efficacy of treatment and prognosis of epilepsy. However, knowledge regarding network mechanism in epilepsy remains limited at present. Further validation through novel investigating techniques data analysis methods are required for its reliable application in the clinical management of individual patients.

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Functional connectivity homogeneity correlates with duration of temporal lobe epilepsy

Cited by 28 publications

References 46 publications

Large‐scale brain networks are distinctly affected in right and left mesial temporal lobe epilepsy

Large‐scale brain networks are distinctly affected in right and left mesial temporal lobe epilepsy

Regional and global connectivity disturbances in focal epilepsy, related neurocognitive sequelae, and potential mechanistic underpinnings

Abnormal Brain Network in Epilepsy and Associated Comorbidites

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