Functional connectivity change across multiple cortical networks relates to episodic memory changes in aging

Fjell, Anders M.; Sneve, Markus Handal; Grydeland, Håkon; Storsve, Andreas Berg; Lange, Ann-Marie G. de; Amlien, Inge K.; Røgeberg, Ole; Walhovd, Kristine B.

doi:10.1016/j.neurobiolaging.2015.08.020

Cited by 68 publications

(56 citation statements)

References 71 publications

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“…The observed correlations of SC and FC measures with age among all seven networks are consistent with published independent DTI (Westlye et al, 2010; Lebel et al, 2012; Chen et al, 2013) and rs-fMRI (Mevel et al, 2013; Cao et al, 2014; Fjell et al, 2015a) human brain aging studies. In these studies, other trajectories, such as quadratic or Poisson trajectories, were used to model age-related changes in SC (FA, MD, AD, RD) or FC across wider age ranges that included children and adolescents.…”

Section: Discussionsupporting

confidence: 86%

“…Higher mean FC was observed for males, though the sex term in the regression model was not significant for FC in any network. Sex differences in FC in healthy adults have been reported in previous studies using graph theory (Cao et al, 2014; Scheinost et al, 2015), however, not in previous rs-fMRI aging studies in normal adults that used the same FC metric as this work (i.e., z-transformed correlation of the averaged BOLD time signal; Wang et al, 2012; Fjell et al, 2015a). …”

Section: Discussionmentioning

confidence: 53%

“…Furthermore, previous studies have also used DTI to demonstrate that the degree of age-related cognitive decline correlates with WM microstructural alterations (Madden et al, 2012; Hawkins et al, 2015). On the other hand, rs-fMRI studies have reported both negative and positive (as well as both linear and non-linear) associations between age and FC, which were dependent on the brain region under investigation (Wang et al, 2012; Cao et al, 2014; Fjell et al, 2015a). In addition, rs-fMRI studies have also demonstrated that cognitive decline is related to decreased FC in the salience network (Onoda et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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White Matter Structural Connectivity Is Not Correlated to Cortical Resting-State Functional Connectivity over the Healthy Adult Lifespan

Tsang

Lebel

Bray

et al. 2017

Front. Aging Neurosci.

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Structural connectivity (SC) of white matter (WM) and functional connectivity (FC) of cortical regions undergo changes in normal aging. As WM tracts form the underlying anatomical architecture that connects regions within resting state networks (RSNs), it is intuitive to expect that SC and FC changes with age are correlated. Studies that investigated the relationship between SC and FC in normal aging are rare, and have mainly compared between groups of elderly and younger subjects. The objectives of this work were to investigate linear SC and FC changes across the healthy adult lifespan, and to define relationships between SC and FC measures within seven whole-brain large scale RSNs. Diffusion tensor imaging (DTI) and resting-state functional MRI (rs-fMRI) data were acquired from 177 healthy participants (male/female = 69/108; aged 18–87 years). Forty cortical regions across both hemispheres belonging to seven template-defined RSNs were considered. Mean diffusivity (MD), fractional anisotropy (FA), mean tract length, and number of streamlines derived from DTI data were used as SC measures, delineated using deterministic tractography, within each RSN. Pearson correlation coefficients of rs-fMRI-obtained BOLD signal time courses between cortical regions were used as FC measure. SC demonstrated significant age-related changes in all RSNs (decreased FA, mean tract length, number of streamlines; and increased MD), and significant FC decrease was observed in five out of seven networks. Among the networks that showed both significant age related changes in SC and FC, however, SC was not in general significantly correlated with FC, whether controlling for age or not. The lack of observed relationship between SC and FC suggests that measures derived from DTI data that are commonly used to infer the integrity of WM microstructure are not related to the corresponding changes in FC within RSNs. The possible temporal lag between SC and FC will need to be addressed in future longitudinal studies to better elucidate the links between SC and FC changes in normal aging.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 53%

Section: Introductionmentioning

confidence: 99%

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White Matter Structural Connectivity Is Not Correlated to Cortical Resting-State Functional Connectivity over the Healthy Adult Lifespan

Tsang

Lebel

Bray

et al. 2017

Front. Aging Neurosci.

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“…Strength of traditional functional connectivity has been linked to performance in episodic memory tasks in aging populations (Fjell et al, 2015; Fjell et al, 2016), bipolar disorder (Oertel-Knochel et al, 2015), and schizophrenia (Haut et al, 2015). In a study measuring availability of dopamine D2 receptors, caudate-hippocampal connectivity was associated with D2 receptor availability and episodic memory, but not processing speed (Nyberg et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Sustained versus instantaneous connectivity differentiates cognitive functions of processing speed and episodic memory

King

Anderson

2018

Human Brain Mapping

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Synchrony of brain activity over time describes the functional connectivity between brain regions but does not address the temporal component of this relationship. We propose a complementary method of analysis by introducing the width of cross-correlation curves between functional MRI (fMRI) time series as a metric of the relative duration of synchronous activity between brain regions, or "sustained connectivity". Using resting-state fMRI, cognitive, and demographics data from 1,003 subjects included in the Human Connectome Project, we find that sustained connectivity is a reproducible trait in individuals, heritable, more transient in females, and shows changes with age in early adulthood. Sustained connectivity in sensory brain regions is specifically associated with differences in processing speed across subjects, particularly in men. In contrast, traditional functional connectivity was correlated with a measure of episodic memory, but not with processing speed. Individual differences in hemodynamic response function (HRF) are closely approximated by sustained connectivity and width of the HRF is also correlated with processing speed across individuals, suggesting that variability in hemodynamic response may be influenced by transient versus sustained neural activity rather than simply differences in vascularity and signal transduction. Sustained connectivity may provide new opportunities to study brain dynamics in clinical populations.

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“…Functional networks estimated by glucose consumption assed by FDG-PET and cortical thickness networks interact during aging, with the first acting as a constraint to the latter (ROMERO-GARCIA; ATIENZA; CANTERO, 2014). The relationship between white matter integrity and functional networks is more elusive (ANDREWS-HANNA et al, 2007;FJELL et al, 2015a;TSANG et al, 2017), but there is enough support to the idea that functional connectivity is somewhat dissociated of structural connectivity (FJELL et al, 2017b;TSANG et al, 2017). Multimodal studies fusing structural and functional connectivity and morphometry in aging are scarce, but overall point to compensatory recruitment of areas and also increased functional connectivity with white-matter integrity preservation (BURIANOVÁ et al, 2015;MARSTALLER et al, 2015).…”

Section: Scientific Findings From Neuroimagingmentioning

confidence: 99%

Brain functional connectivity in regions that exhibit age-related cortical thinning

Vieira¹

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Functional connectivity change across multiple cortical networks relates to episodic memory changes in aging

Cited by 68 publications

References 71 publications

White Matter Structural Connectivity Is Not Correlated to Cortical Resting-State Functional Connectivity over the Healthy Adult Lifespan

White Matter Structural Connectivity Is Not Correlated to Cortical Resting-State Functional Connectivity over the Healthy Adult Lifespan

Sustained versus instantaneous connectivity differentiates cognitive functions of processing speed and episodic memory

Brain functional connectivity in regions that exhibit age-related cortical thinning

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