Functional Connectivity Bias of the Orbitofrontal Cortex in Drug-Free Patients with Major Depression

Frodl, Thomas; Bokde, Arun L.W.; Scheuerecker, Johanna; Lisiecka, Danuta; Schoepf, Veronika; Hampel, Harald; Möller, Hans‐Jürgen; Brückmann, H.; Wiesmann, Martin; Meisenzahl, Eva

doi:10.1016/j.biopsych.2009.08.022

Cited by 165 publications

(106 citation statements)

References 34 publications

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“…28 Recently, we showed that the connectivity between the orbitofrontal cortex and the cingulate, precuneus and cerebellar region is decreased and that connectivity between the orbitofrontal cortex and the dorsolateral prefrontal cortex and motor regions is increased in drug-free patients with major depression, indicating a functional dysbalance. 29 To the best of our knowledge, there has been only one study that combined fMRI and voxel-based morphometry in patients with major depression. 30 This study showed that hyperactivation of the anterior cingulate cortex of unmedicated patients during a Stroop task was inversely correlated with grey matter reduction in the orbitofrontal cortex.…”

Section: Introductionmentioning

confidence: 99%

Orbitofrontal volume reductions during emotion recognition in patients with major depression

Scheuerecker

Meisenzahl

Koutsouleris

et al. 2010

jpn

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107

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311Background: Major depressive disorder is associated with both structural and functional alterations in the emotion regulation network of the central nervous system. The relation between structural and functional changes is largely unknown. Therefore, we sought to determine the relation between structural differences and functional alterations during the recognition of emotional facial expressions. Methods: We examined 13 medication-free patients with major depression and 15 healthy controls by use of structural T 1 -weighted high-resolution magnetic resonance imaging (MRI) and functional MRI during 1 session. We set the statistical threshold for the analysis of imaging data to p < 0.001 (uncorrected). Results: As shown by voxel-based morphometry, depressed patients had reductions in orbitofrontal cortex volume and increases in cerebellar volume. Additionally, depressed patients showed increased activity during emotion recognition in the middle frontal cortex, caudate nucleus, precuneus and lingual gyrus. Within this cerebral network, the orbitofrontal volumes were negatively correlated in depressed patients but not in healthy controls with changes in blood oxygen level-dependent signal in the middle frontal gyrus, caudate nucleus, precuneus and supplementary motor area. Limitations: Our results are limited by the relatively small sample size. Conclusions: This combined functional and structural MRI study provides evidence that the orbitofrontal cortex is a key area in major depression and that structural changes result in functional alterations within the emotional circuit. Whether these alterations in the orbitofrontal cortex are also related to persistent emotional dysfunction in remitted mental states and, therefore, are related to the risk of depression needs further exploration.

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Section: Introductionmentioning

confidence: 99%

Orbitofrontal volume reductions during emotion recognition in patients with major depression

Scheuerecker

Meisenzahl

Koutsouleris

et al. 2010

jpn

Self Cite

107

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“…Nonetheless, patients with acute mood episodes show reduced dlPFC activity during tasks that require emotional regulation and emotional anticipation [99][100][101][102]. In addition, patients show reduced functional connectivity among the OFC, the dorsal ACC, the precuneus, and the amygdala [103,104]. On the other hand, these patients present an increase of functional connectivity between the rostral ACC and the hippocampus, which are two important areas of the DMN, together with structural alterations in the white matter that correlate with symptom severity [105].…”

Section: Neurobiological Studies Have Shown Thatmentioning

confidence: 99%

Social cognition in major depressive disorder: A new paradigm?

Billeke

Boardman

Doraiswamy

2013

Translational Neuroscience

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Social cognition refers to the brain mechanisms by which we process social information about other humans and ourselves. Alterations in interpersonal and social functioning are common in major depressive disorder, though only poorly addressed by current pharmacotherapies. Further standardized tests, such as depression ratings or neuropsychologic tests, used in routine practice provide very little information on social skills, schemas, attributions, stereotypes and judgments related to social interactions. In this article, we review recent literature on how healthy human brains process social decisions and how these processes are altered in major depressive disorder. We especially focus on interactive paradigms (e.g., game theory based tasks) that can reproduce daily life situations in laboratory settings. The evidences we review, together with the rich literature on the protective role of social networks in handling stress, have implications for developing more ecologically-valid biomarkers and interventions in order to optimize functional recovery in depressive disorders.

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“…Several task-related fMRI studies have shown functional connectivity abnormalities in MDD (Johnstone et al 2007 ;Chen et al 2008 ;Frodl et al 2010), but their results are inconsistent. The conflicting findings may be due to differences in brain activation between various paradigms or the existence of highfunctioning resting-state patients.…”

Section: Introductionmentioning

confidence: 99%

“…The fundamental mechanisms underlying the emotional dysregulation of MDD remain unclear ; however, these mechanisms are likely to involve the neural system that subserves emotional processing, including its key components, the prefrontal cortex (PFC) and the amygdala. Convergent studies provide support for abnormalities in the structure and function of the PFC and the amygdala in MDD (Mayberg et al 1999 ;Dougherty et al 2004 ;Johnstone et al 2007 ;Lee et al 2008 ;MacQueen, 2009 ;Frodl et al 2010). Positron emission tomography (PET) studies have shown increased metabolism in the amygdala (Drevets et al 2002) and decreased metabolism in the PFC in MDD (Sackeim et al 1990) ; similarly, functional magnetic resonance imaging (fMRI) studies have shown increased activation in the amygdala (Sheline et al 2001 ;Anand et al 2005a ;Siegle et al 2007) and decreased activation in the PFC in MDD (Siegle et al 2007 ; Lee et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Decreased functional connectivity between the amygdala and the left ventral prefrontal cortex in treatment-naive patients with major depressive disorder: a resting-state functional magnetic resonance imaging study

et al. 2012

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Tang, Y.; Kong, L.; Womer, F.; Jiang, W.; Cao, Y.; Ren, L.; Wang, J.; Fan, G.; Blumberg, H. P.; Xu, K.; and Wang, F., ,"Decreased functional connectivity between the amygdala and the left ventral prefrontal cortex in treatment-naive patients with major depressive disorder: A resting-state functional magnetic resonance imaging study. " Psychological Medicine.43,9. 1921-1927. (2012 Background. Convergent studies provide support for abnormalities in the structure and functioning of the prefrontal cortex (PFC) and the amygdala, the key components of the neural system that subserves emotional processing in major depressive disorder (MDD). We used resting-state functional magnetic resonance imaging (fMRI) to examine potential amygdala-PFC functional connectivity abnormalities in treatment-naive subjects with MDD.Methods. Resting-state fMRI data were acquired from 28 individuals with MDD and 30 healthy control (HC) subjects. Amygdala-PFC functional connectivity was compared between the MDD and HC groups.Results. Decreased functional connectivity to the left ventral PFC (VPFC) from the left and right amygdala was observed in the MDD group, compared with the HC group (p<0.05, corrected).Conclusions. The treatment-naive subjects with MDD showed decreased functional connectivity from the amygdala to the VPFC, especially to the left VPFC. This suggests that these connections may play an important role in the neuropathophysiology of MDD at its onset.

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Functional Connectivity Bias of the Orbitofrontal Cortex in Drug-Free Patients with Major Depression

Cited by 165 publications

References 34 publications

Orbitofrontal volume reductions during emotion recognition in patients with major depression

Orbitofrontal volume reductions during emotion recognition in patients with major depression

Social cognition in major depressive disorder: A new paradigm?

Decreased functional connectivity between the amygdala and the left ventral prefrontal cortex in treatment-naive patients with major depressive disorder: a resting-state functional magnetic resonance imaging study

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